Treatment of hepatitis B virus: an update.

Abstract:

:Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from infected individuals (functional cure) remains an issue. Due to persistence of HBV DNA (cccDNA) in infected cells, chronically infected patients who discontinue therapy prior to HBsAg loss or seroconversion are likely to relapse. Several novel therapeutic strategies are being researched and studied in clinical trials. Here we review these novel strategies to achieve sustained cure or elimination of HBV. These strategies include the targeting of the host or viral factors required for viral persistence as well as therapeutic vaccines.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Ward H,Tang L,Poonia B,Kottilil S

doi

10.2217/fmb-2016-0128

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1581-1597

eissn

1746-0913

issn

1746-0921

journal_volume

11

pub_type

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