Tregs in the immune response of BALB/c mice experimentally infected with species of the Sporothrix genus.

Abstract:

:Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We used flow cytometry to quantify TCD4+ and TCD8+ and Treg from immunocompetent and immunosuppressed mice infected with Sporothrix species with different levels of virulence and pathogenicity. Results: It was demonstrated the predominance of TCD4+ over the TCD8+ cells in both groups, inoculated with all the species, and percentages of Treg observed in infected immunocompetent mice. Conclusion: This regulatory phenotype can be associated with a protective immunity in the initial periods of infection.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Corrêa-Moreira D,De Luca PM,Romeo O,C Menezes R,Paes RA,Oliveira RZ,de Moraes AM,de L Neto RG,Moraes Borba C,E de Oliveira MM

doi

10.2217/fmb-2020-0046

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1217-1225

eissn

1746-0913

issn

1746-0921

journal_volume

15

pub_type

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