Septic patients in the intensive care unit present different nasal microbiotas.


AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dominated by three nasal bacterial types (Corynebacterium, Staphylococcus and Acinetobacter). The Acinetobacter type was associated with the lowest diversity and longest length of stay (median: 9 days), and the Corynebacterium type was associated with the shortest length of stay. We found that the Acinetobacter type in the >9-day group was associated with the highest mortality (33%). CONCLUSION:Septic patients have three nasal microbiota types, and the nasal microbiota is related to the length of stay and mortality.


Future Microbiol


Future microbiology


Tan XL,Liu HY,Long J,Jiang Z,Luo Y,Zhao X,Cai S,Zhong X,Cen Z,Su J,Zhou H




Has Abstract


2019-03-01 00:00:00










  • Lectins as virulence factors in Entamoeba histolytica and free-living amoebae.

    abstract::Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Guzmán-Téllez P,Martínez-Castillo M,Flores-Huerta N,Rosales-Morgan G,Pacheco-Yépez J,la Garza M,Serrano-Luna J,Shibayama M

    更新日期:2020-07-01 00:00:00

  • Effects of hyperbaric oxygen on Pseudomonas aeruginosa susceptibility to imipenem and macrophages.

    abstract:BACKGROUND:The seriousness to treat burn wounds infected with Pseudomonas aeruginosa led us to examine whether the effect of the carbapenem antibiotic imipenem is enhanced by hyperbaric oxygen (HBO). MATERIALS & METHODS:The effects of HBO (100% O2, 3 ATA, 5 h) in combination with imipenen on bacterial counts of six is...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Lima FL,Joazeiro PP,Lancellotti M,de Hollanda LM,de Araújo Lima B,Linares E,Augusto O,Brocchi M,Giorgio S

    更新日期:2015-01-01 00:00:00

  • Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.

    abstract::Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped into two distinct therapeutic groups, namely the nucleoside and nucleotide RT inhibitors (NRTIs), and the non-nucleoside RT inhibitors (NNRTI...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Sluis-Cremer N,Wainberg MA,Schinazi RF

    更新日期:2015-01-01 00:00:00

  • Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria.

    abstract::Biocides, primarily those containing quaternary ammonium compounds (QAC), are heavily used in hospital environments and various industries (e.g., food, water, cosmetic). To date, little attention has been paid to potential implications of QAC use in the emergence of antibiotic resistance, especially fluoroquinolone-re...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Buffet-Bataillon S,Tattevin P,Maillard JY,Bonnaure-Mallet M,Jolivet-Gougeon A

    更新日期:2016-01-01 00:00:00

  • Emergence of two distinct subpopulations from Klebsiella pneumoniae grown in the stimulated microgravity environment.

    abstract:AIM:To isolate and characterize the two phenotypically distinct subpopulations from Klebsiella pneumoniae clonal cultures grown in the simulate microgravity environment. MATERIALS & METHODS:Here clonal culture of K. pneumoniae strain ATCC BAA-1705 was grown within a vertically rotating wall vessel bioreactor. Microsco...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Wang H,Li W,Gu L,Gao X,Ni B,Deng H,Yang R,Han Y

    更新日期:2017-09-01 00:00:00

  • The dominance of bacterial genotypes leads to susceptibility variations under sublethal antibiotic pressure.

    abstract:AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Xu S,Yang J,Yin C,Zhao X

    更新日期:2018-02-01 00:00:00

  • Controversies in the treatment of pneumococcal community-acquired pneumonia.

    abstract::Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Feldman C,Anderson R

    更新日期:2006-10-01 00:00:00

  • Origin of hepatitis delta virus.

    abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Taylor J,Pelchat M

    更新日期:2010-03-01 00:00:00

  • Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?

    abstract::Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Al-Dujaili LJ,Clerkin PP,Clement C,McFerrin HE,Bhattacharjee PS,Varnell ED,Kaufman HE,Hill JM

    更新日期:2011-08-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • Vitamin B(12) metabolism in Mycobacterium tuberculosis.

    abstract::Mycobacterium tuberculosis is included among a select group of bacteria possessing the capacity for de novo biosynthesis of vitamin B12, the largest and most complex natural organometallic cofactor. The bacillus is also able to scavenge B12 and related corrinoids utilizing an ATP-binding cassette-type protein that is ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Gopinath K,Moosa A,Mizrahi V,Warner DF

    更新日期:2013-11-01 00:00:00

  • Prospects for defined epitope vaccines for respiratory syncytial virus.

    abstract::The history of vaccines for respiratory syncytial virus (RSV) illustrates the complex immunity and immunopathology to this ubiquitous virus, starting from the failed formalin-inactivated vaccine trials performed in the 1960s. An attractive alternative to traditional live or killed virus vaccines is a defined vaccine c...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Anderson R,Huang Y,Langley JM

    更新日期:2010-04-01 00:00:00

  • Staphylococcal disease in Africa: another neglected 'tropical' disease.

    abstract::The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in tropical and devel...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Herrmann M,Abdullah S,Alabi A,Alonso P,Friedrich AW,Fuhr G,Germann A,Kern WV,Kremsner PG,Mandomando I,Mellmann AC,Pluschke G,Rieg S,Ruffing U,Schaumburg F,Tanner M,Peters G,von Briesen H,von Eiff C,von Müller L,Gr

    更新日期:2013-01-01 00:00:00

  • Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies.

    abstract::Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive tumors. A subset of these viruses termed 'high risk' infect the cervix where persistent infection can lead to cervical cancer. Although many HPV genomes have been sequenced, knowledge of virus gene expression and its regulation is still...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Graham SV

    更新日期:2010-10-01 00:00:00

  • Nosocomial infections in leukemic and solid-tumor cancer patients: distribution, outcome and microbial spectrum of anaerobes.

    abstract:AIMS:Nosocomial infections cause significant morbidity and mortality in cancer patients. As a result of their debilitated immune system, cancer patients are likely candidates for colonization with anaerobes. We sought to compare the distribution of nosocomial infections in neutropenic and non-neutropenic cancer patient...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: El-Sharif A,Elkhatib WF,Ashour HM

    更新日期:2012-12-01 00:00:00

  • Candida albicans vaginitis in a murine model is reduced by polypeptide-enriched Gastrodia elata extracts.

    abstract::Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-formi...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Cai X,Kong F,Wang R,Zhai S,Guan X,Zhang G,Wang D

    更新日期:2019-07-01 00:00:00

  • The differential effect of clarithromycin and azithromycin on induction of macrolide resistance in Mycobacterium abscessus.

    abstract::Aim: Antibiotic resistance in Mycobacterium abscessus renders treatment poorly effective. Despite erm(41)-gene-mediated macrolide resistance, treatment with azithromycin or clarithromycin is recommended. It is contested whether macrolides differ in erm(41) induction. We determine whether this is the case. Methods:M. a...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Schildkraut JA,Pennings LJ,Ruth MM,de Brouwer AP,Wertheim HF,Hoefsloot W,de Jong A,van Ingen J

    更新日期:2019-06-01 00:00:00

  • Detection of Helicobacter pylori in gastric cancer tissue through histopathology, immunohistochemistry and real-time reverse transcription-PCR.

    abstract::Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: A Castaneda C,Castillo M,Sanchez J,Casavilca S,Sanchez J,A Bernabe L,Suarez N,Chavez I,Ruiz E,Tello K,R Villa M,Zevallos R,Montenegro P,Dias-Neto E,Landa-Baella M,Taxa L

    更新日期:2020-08-01 00:00:00

  • HSV-1 ICP22: hijacking host nuclear functions to enhance viral infection.

    abstract::During its productive infection, HSV-1 dramatically remodels the architecture and physiology of the host cell nucleus. The immediate-early proteins, the first viral proteins to be expressed during infection, are key players in this process. Here, we review the known properties and functions of immediate-early protein ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rice SA,Davido DJ

    更新日期:2013-03-01 00:00:00

  • MAPK cell-cycle regulation in Saccharomyces cerevisiae and Candida albicans.

    abstract::The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-depende...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Correia I,Alonso-Monge R,Pla J

    更新日期:2010-07-01 00:00:00

  • Bioguided identification of antimicrobial compounds from Chrysopogon zizaniodes (L.) Roberty root essential oil.

    abstract::Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ramírez-Rueda RY,Marinho J,Salvador MJ

    更新日期:2019-09-01 00:00:00

  • SAMHD1: a novel antiviral factor in intrinsic immunity.

    abstract::Some intracellular/membranous factors exert intrinsic immunity against viral pathogens. Most recently, SAMHD1 has been shown to be one of these factors. SAMHD1 is a nucleus-localized protein, and mutations in the gene are associated with Aicardi-Goutières syndrome. As a triphosphohydrolase, it depletes the intracellul...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Chen Z,Zhang L,Ying S

    更新日期:2012-09-01 00:00:00

  • Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis.

    abstract:AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) rende...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Correia I,Román E,Prieto D,Eisman B,Pla J

    更新日期:2016-01-01 00:00:00

  • Oritavancin: a potential weapon in the battle against serious Gram-positive pathogens.

    abstract::Oritavancin is a lipoglycopeptide antibiotic with activity against aerobic and anaerobic Gram-positive bacteria. Oritavancin separates itself from other glycopeptides through its potent in vitro activity against resistant isolates of Staphylococcus aureus, Enterococcus spp. and Streptococcus spp. Oritavancin possesses...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Crandon J,Nicolau DP

    更新日期:2008-06-01 00:00:00

  • Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children.

    abstract::Retapamulin is a semisynthetic pleuromutilin compound with in vitroactivity against Gram-positive bacteria, no cross-resistance to other classes of antimicrobial agents in current use and a low potential for development of resistance. A 1% ointment formulation has been developed for clinical use, and a placebo-control...

    journal_title:Future microbiology

    pub_type: 临床试验,杂志文章


    authors: Jacobs MR

    更新日期:2007-12-01 00:00:00

  • Methods for culturing anaerobes from human specimen.

    abstract::Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Guilhot E,Khelaifia S,La Scola B,Raoult D,Dubourg G

    更新日期:2018-03-01 00:00:00

  • Potential for adaptation overrides cost of resistance.

    abstract:AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolution...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Moura de Sousa J,Sousa A,Bourgard C,Gordo I

    更新日期:2015-01-01 00:00:00

  • Do Aspergillus species produce biofilm?

    abstract::Evaluation of: Mowat E, Butcher J, Lang S, Williams C, Ramage G: Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J. Med. Microbiol. 56, 1205-1212 (2007). Many microorganisms possess the innate ability for adhering to biotic and abiotic ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Chandrasekar PH,Manavathu EK

    更新日期:2008-02-01 00:00:00

  • Nosocomial Gram-positive antimicrobial susceptibility pattern at a referral teaching hospital in Tehran, Iran.

    abstract:AIMS:The aim of the study was to evaluate epidemiology and susceptibility patterns of nosocomial Gram-positive infections in a referral teaching hospital. METHODS:Over a 1 year period, Gram-positive microorganisms isolated from specimens of hospitalized patients with documented nosocomial infection underwent antimicro...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Soltani R,Khalili H,Abdollahi A,Rasoolinejad M,Dashti-Khavidaki S

    更新日期:2012-07-01 00:00:00

  • In vitro susceptibility testing in Aspergillus species: an update.

    abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Lass-Flörl C

    更新日期:2010-05-01 00:00:00