Septic patients in the intensive care unit present different nasal microbiotas.

Abstract:

AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dominated by three nasal bacterial types (Corynebacterium, Staphylococcus and Acinetobacter). The Acinetobacter type was associated with the lowest diversity and longest length of stay (median: 9 days), and the Corynebacterium type was associated with the shortest length of stay. We found that the Acinetobacter type in the >9-day group was associated with the highest mortality (33%). CONCLUSION:Septic patients have three nasal microbiota types, and the nasal microbiota is related to the length of stay and mortality.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Tan XL,Liu HY,Long J,Jiang Z,Luo Y,Zhao X,Cai S,Zhong X,Cen Z,Su J,Zhou H

doi

10.2217/fmb-2018-0349

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

383-395

eissn

1746-0913

issn

1746-0921

journal_volume

14

pub_type

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