Cif type III effector protein: a smart hijacker of the host cell cycle.

abstract：:This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

journal_title：Future microbiology

authors： Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

更新日期：2015-01-01 00:00:00

abstract：:Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...

journal_title：Future microbiology

authors： Zilberman-Itskovich S,Youngster I,Lazarovitch T,Bondarenco M,Toledano L,Kachlon Y,Mengesha B,Strul N,Zaidenstein R,Marchaim D

更新日期：2019-11-01 00:00:00

abstract：:Evaluation of: Mowat E, Butcher J, Lang S, Williams C, Ramage G: Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J. Med. Microbiol. 56, 1205-1212 (2007). Many microorganisms possess the innate ability for adhering to biotic and abiotic ...

journal_title：Future microbiology

authors： Chandrasekar PH,Manavathu EK

更新日期：2008-02-01 00:00:00

abstract：:Mark Wilcox speaks to Georgia Patey, Commissioning Editor: Professor Mark Wilcox is a Consultant Microbiologist and Head of Microbiology at the Leeds Teaching Hospitals (Leeds, UK), the Professor of Medical Microbiology at the University of Leeds (Leeds, UK), and is the Lead on Clostridium difficile and the Head of th...

journal_title：Future microbiology

authors： Wilcox M

更新日期：2016-08-01 00:00:00

abstract：:Cooling towers provide a favorable environment for the proliferation of microorganisms. Cooling towers generate a biofilm and often aerosolize contaminated water, thereby increasing the risk of microorganism dissemination by human inhalation. This pathogen dissemination was first revealed by the epidemics of Legionnai...

journal_title：Future microbiology

authors： Pagnier I,Merchat M,La Scola B

更新日期：2009-06-01 00:00:00

abstract：:Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review desc...

journal_title：Future microbiology

authors： Mancini N,Marrone L,Clementi N,Sautto GA,Clementi M,Burioni R

更新日期：2015-01-01 00:00:00

abstract：:The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-depende...

journal_title：Future microbiology

authors： Correia I,Alonso-Monge R,Pla J

更新日期：2010-07-01 00:00:00

abstract：:Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from...

journal_title：Future microbiology

authors： Ward H,Tang L,Poonia B,Kottilil S

更新日期：2016-12-01 00:00:00

abstract：:Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-imp...

journal_title：Future microbiology

authors： van der Eijk AA,Tintu AN,Hays JP

更新日期：2017-01-01 00:00:00

abstract：:This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...

journal_title：Future microbiology

authors： Taylor J,Pelchat M

更新日期：2010-03-01 00:00:00

abstract：:In light of recent studies based on cultivation-independent methods, it appears that the diversity of Prevotella in human microbiota is greater than was previously assumed from cultivation-based studies, and that the implication of these bacteria in several human diseases was unrecognized. While some Prevotella taxa w...

journal_title：Future microbiology

authors： Alauzet C,Marchandin H,Lozniewski A

更新日期：2010-11-01 00:00:00

abstract：AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dom...

journal_title：Future microbiology

authors： Tan XL,Liu HY,Long J,Jiang Z,Luo Y,Zhao X,Cai S,Zhong X,Cen Z,Su J,Zhou H

更新日期：2019-03-01 00:00:00

abstract：:Infections with Pseudomonas aeruginosa are a major health problem, especially for immune-compromised and cystic fibrosis patients, owing to the particular drug resistance of the microorganism. The aim of this review is to provide recent insights into strategies under investigation for prevention and therapy of these i...

journal_title：Future microbiology

authors： Savoia D

更新日期：2014-01-01 00:00:00

abstract：AIM:To investigate the role of Cat1 overproduction in Candida albicans. MATERIALS & METHODS:Strains overproducing the CAT1 gene were constructed. RESULTS:Cells overproducing CAT1 were found to be more resistant to some oxidants and mammalian phagocytic cells. They also showed reduced intracellular reactive oxygen spe...

journal_title：Future microbiology

authors： Román E,Prieto D,Martin R,Correia I,Mesa Arango AC,Alonso-Monge R,Zaragoza O,Pla J

更新日期：2016-10-01 00:00:00

abstract：:During its productive infection, HSV-1 dramatically remodels the architecture and physiology of the host cell nucleus. The immediate-early proteins, the first viral proteins to be expressed during infection, are key players in this process. Here, we review the known properties and functions of immediate-early protein ...

journal_title：Future microbiology

authors： Rice SA,Davido DJ

更新日期：2013-03-01 00:00:00

abstract：:Histoplasma capsulatum, an environmental fungus, is the most common endemic pulmonary mycosis in the USA. Disease is most frequently observed in immunocompromised patients living in endemic areas. We present the mechanisms of fungal recognition, innate immune response and adaptive immune response that lead to protecti...

journal_title：Future microbiology

authors： Horwath MC,Fecher RA,Deepe GS Jr

更新日期：2015-01-01 00:00:00

abstract：:Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...

journal_title：Future microbiology

authors： Rivera-Chaparro ND,Cohen-Wolkowiez M,Greenberg RG

更新日期：2017-09-01 00:00:00

abstract：AIMS:AFN-1252 is a novel inhibitor of FabI, an essential enzyme in Staphylococcus spp. This study was undertaken to assess the safety, tolerability and pharmacokinetic properties of AFN-1252, following oral administration in an ascending dose trial. MATERIALS & METHODS:This was a double-blind, randomized, placebo-cont...

journal_title：Future microbiology

authors： Hafkin B,Kaplan N,Hunt TL

更新日期：2015-01-01 00:00:00

abstract：:Background: A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of Mycobacterium tuberculosis. Results: We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward M. tuberculosis H37Rv and isoni...

journal_title：Future microbiology

authors： Volynets GP,Tukalo MA,Bdzhola VG,Derkach NM,Gumeniuk MI,Tarnavskiy SS,Yarmoluk SM

更新日期：2020-07-01 00:00:00

abstract：:Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...

journal_title：Future microbiology

authors： Pich OQ,Merrell DS

更新日期：2013-06-01 00:00:00

abstract：:A multidisplay vaccine delivery system has been developed that is nonreplicating and has a protein-based particulate structure. The structure is composed of helical tubules comprising multiple copies of a single nonstructural (NS) protein 1 of bluetongue virus. The helical assemblies present the C terminus of the prot...

journal_title：Future microbiology

authors： Murphy A,Roy P

更新日期：2008-06-01 00:00:00

abstract：AIM:To understand the relationship between ica, aap and bhp gene expression and the implications in biofilm formation in selected clinical and commensal Staphylococcus epidermidis isolates. MATERIAL & METHODS:Isolates were analyzed regarding their biofilm-forming capacity, biochemical matrix composition, biofilm spati...

journal_title：Future microbiology

authors： Freitas AI,Lopes N,Oliveira F,Brás S,França Â,Vasconcelos C,Vilanova M,Cerca N

更新日期：2018-03-01 00:00:00

abstract：AIM:The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS:Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly a...

journal_title：Future microbiology

authors： Marchaim D,Levit D,Zigron R,Gordon M,Lazarovitch T,Carrico JA,Chalifa-Caspi V,Moran-Gilad J

更新日期：2017-03-01 00:00:00

abstract：:Bacillus anthracis is a Gram-positive, spore-forming bacterium representing the etiological cause of anthrax, a rare lethal disease of animals and humans. Development of anthrax countermeasures has gained increasing attention owing to the potential use of B. anthracis spores as a bioterror weapon. The various forms of...

journal_title：Future microbiology

authors： Chitlaru T,Shafferman A

更新日期：2009-10-01 00:00:00

abstract：:In the past few months, there has been public discussion relating to a new perspective on blood safety and specifically upon measures to prevent or discourage donation by individuals with a diagnosis of myalgic encephalopathy-chronic fatigue syndrome. This reflects an intriguing interplay between science, public healt...

journal_title：Future microbiology

authors： Dodd RY

更新日期：2011-04-01 00:00:00

abstract：:Background: There is increasing evidence of the association between microbiome dysfunction and Parkinson's disease (PD). Moreover, some PD patients suffer from unintentional weight loss (WL) which may precede the motor manifestations of the disease. Materials & methods: Gut microbiota profiling by 16S rRNA gene sequen...

journal_title：Future microbiology

authors： Del Chierico F,Grassini P,Quagliariello A,Torti M,Russo A,Reddel S,Stocchi F

更新日期：2020-09-01 00:00:00

abstract：:Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were signific...

journal_title：Future microbiology

authors： Guo M,Yao J,Yang F,Liu W,Bai H,Ma J,Ma X,Zhang J,Fang Y,Miao Y,Sun J,Zhang Y,Zhao H

更新日期：2020-02-01 00:00:00

abstract：AIM:Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans. MATERIALS & METHODS:A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The functio...

journal_title：Future microbiology

authors： Zhang D,Dong Y,Yu Q,Kai Z,Zhang M,Jia C,Xiao C,Zhang B,Zhang B,Li M

更新日期：2017-11-01 00:00:00

abstract：AIM:To compare two identification methods for coagulase-negative staphylococci (CoNS) isolated from patients with urinary tract infections, VITEK® 2 and MALDI-TOF VITEK®MS, with genotypic identification by internal transcribed spacer PCR (ITS-PCR). RESULTS:A total of 217 CoNS isolates were studied. Agreement of the VI...

journal_title：Future microbiology

authors： Martins KB,Ferreira AM,Mondelli AL,Rocchetti TT,Lr de S da Cunha M

更新日期：2018-11-01 00:00:00

abstract：:Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, t...

journal_title：Future microbiology

authors： Eckmann C,Rojas LJ,Lyon S

更新日期：2018-10-01 00:00:00