Antibodies as a source of anti-infective peptides: an update.

Abstract:

:This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune system and to the latest experimental evidence of Abs as a source of anti-infective and antitumor peptides derived from their complementarity determining regions and constant regions.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

doi

10.2217/fmb.15.36

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1163-75

issue

7

eissn

1746-0913

issn

1746-0921

journal_volume

10

pub_type

杂志文章,评审
  • Do Aspergillus species produce biofilm?

    abstract::Evaluation of: Mowat E, Butcher J, Lang S, Williams C, Ramage G: Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J. Med. Microbiol. 56, 1205-1212 (2007). Many microorganisms possess the innate ability for adhering to biotic and abiotic ...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/17460913.3.1.19

    authors: Chandrasekar PH,Manavathu EK

    更新日期:2008-02-01 00:00:00

  • Antibiotic resistance: challenges and successes in respiratory infection.

    abstract::European Respiratory Society Congress, Amsterdam, 26-30 September 2015, and CHEST 2015, Montréal, Canada, 24-28 October 2015 With approximately 50,000 deaths in the US and EU attributed to antibacterial resistance each year, together with several million days of hospital care [1], the need to address resistance mechan...

    journal_title:Future microbiology

    pub_type:

    doi:10.2217/fmb-2016-0006

    authors: Sethi S,Bryan J

    更新日期:2016-01-01 00:00:00

  • Comparison of antibiotic susceptibility of old and current Serratia.

    abstract:AIMS:We explored changes in antibiotic susceptibility of Serratia marcescens in the last 50 years by comparing isolates collected between 1945 and 1950, and current isolates. MATERIALS & METHODS:Isolates were divided into three groups: environmental, clinical and 'old'. Susceptibility was determined by microdilution. ...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.12.40

    authors: Fusté E,Galisteo GJ,Jover L,Vinuesa T,Villa TG,Viñas M

    更新日期:2012-06-01 00:00:00

  • Cif type III effector protein: a smart hijacker of the host cell cycle.

    abstract::During coevolution with their hosts, bacteria have developed functions that allow them to interfere with the mechanisms controlling the proliferation of eukaryotic cells. Cycle inhibiting factor (Cif) is one of these cyclomodulins, the family of bacterial effectors that interfere with the host cell cycle. Acquired ear...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.09.60

    authors: Samba-Louaka A,Taieb F,Nougayrède JP,Oswald E

    更新日期:2009-09-01 00:00:00

  • Epidemiology and virulence insights from MRSA and MSSA genome analysis.

    abstract::Staphylococcus aureus is a major human pathogen responsible for a wide diversity of infections ranging from localized to life threatening diseases. From 1961 and the emergence of methicillin-resistant S. aureus (MRSA), this bacterium has shown a particular capacity to survive and adapt to drastic environmental changes...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.11.38

    authors: Lazarevic V,Beaume M,Corvaglia A,Hernandez D,Schrenzel J,François P

    更新日期:2011-05-01 00:00:00

  • Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.

    abstract::The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.77

    authors: Dunn JD,Valdivia RH

    更新日期:2010-08-01 00:00:00

  • HSV-1 ICP22: hijacking host nuclear functions to enhance viral infection.

    abstract::During its productive infection, HSV-1 dramatically remodels the architecture and physiology of the host cell nucleus. The immediate-early proteins, the first viral proteins to be expressed during infection, are key players in this process. Here, we review the known properties and functions of immediate-early protein ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.13.4

    authors: Rice SA,Davido DJ

    更新日期:2013-03-01 00:00:00

  • Antibiotic-associated diarrhea: epidemiology, trends and treatment.

    abstract::A common complication of antibiotic use is the development of gastrointestinal disease. This complication ranges from mild diarrhea to pseudomembranous colitis. Outbreaks of antibiotic-associated diarrhea (AAD) may also occur in healthcare settings, usually caused by Clostridium difficile. AAD typically occurs in 5-35...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/17460913.3.5.563

    authors: McFarland LV

    更新日期:2008-10-01 00:00:00

  • Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies.

    abstract::Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies includin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.165

    authors: Kato-Maeda M,Metcalfe JZ,Flores L

    更新日期:2011-02-01 00:00:00

  • Know your enemy: managing resistant Gram-negative infections.

    abstract::Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, t...

    journal_title:Future microbiology

    pub_type:

    doi:10.2217/fmb-2018-0202

    authors: Eckmann C,Rojas LJ,Lyon S

    更新日期:2018-10-01 00:00:00

  • Comparative evaluation of GeneXpert MTB/RIF and multiplex PCR targeting mpb64 and IS6110 for the diagnosis of pleural TB.

    abstract:AIM:Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS:We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2017-0147

    authors: Sharma S,Dahiya B,Sreenivas V,Singh N,Raj A,Sheoran A,Yadav A,Gupta KB,Mehta PK

    更新日期:2018-03-01 00:00:00

  • Methods for culturing anaerobes from human specimen.

    abstract::Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb-2017-0170

    authors: Guilhot E,Khelaifia S,La Scola B,Raoult D,Dubourg G

    更新日期:2018-03-01 00:00:00

  • Dosing antibiotics in neonates: review of the pharmacokinetic data.

    abstract::Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2017-0058

    authors: Rivera-Chaparro ND,Cohen-Wolkowiez M,Greenberg RG

    更新日期:2017-09-01 00:00:00

  • Structure-enhanced methods in the development of non-nucleoside inhibitors targeting HIV reverse transcriptase variants.

    abstract::Resistance continues to emerge as a leading cause for antiretroviral treatment failure. Several mutations in HIV reverse transcriptase (RT) confer resistance to non-nucleoside inhibitors (NNRTIs), vital components of antiretroviral combination therapies. Since the majority of mutations are located in the NNRTI binding...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.122

    authors: Frey KM

    更新日期:2015-01-01 00:00:00

  • Endothelial cells and CMV dissemination.

    abstract::Using the murine CMV animal model and the well-established model of Cre-lox-P-mediated green-fluorescence tagging of endothelial cell (EC)-derived mouse CMV to quantify the role of infected ECs in transplantation-associated CMV dissemination (in mice expressing Cre recombinase under the control of either the Tie2 or t...

    journal_title:Future microbiology

    pub_type: 评论,杂志文章

    doi:10.2217/fmb.12.12

    authors: Gerna G

    更新日期:2012-04-01 00:00:00

  • Asaia lannensis bacteremia in a 'needle freak' patient.

    abstract::The genus Asaia has gained much interest lately owing to constant new species discoveries and its role as a potential opportunistic pathogen to humans. Here we describe a transient bacteremia due to Asaia lannensis in a patient with a psychiatric disorder (compulsive self-injection of different substances). Common phe...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.15.126

    authors: Carretto E,Visiello R,Bardaro M,Schivazappa S,Vailati F,Farina C,Barbarini D

    更新日期:2016-01-01 00:00:00

  • Myxopyronin: a punch in the jaws of bacterial RNA polymerase.

    abstract::Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/17460913.4.2.145

    authors: Tupin A,Gualtieri M,Brodolin K,Leonetti JP

    更新日期:2009-03-01 00:00:00

  • Tregs in the immune response of BALB/c mice experimentally infected with species of the Sporothrix genus.

    abstract::Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We us...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2020-0046

    authors: Corrêa-Moreira D,De Luca PM,Romeo O,C Menezes R,Paes RA,Oliveira RZ,de Moraes AM,de L Neto RG,Moraes Borba C,E de Oliveira MM

    更新日期:2020-09-01 00:00:00

  • Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates.

    abstract:AIM:To understand the relationship between ica, aap and bhp gene expression and the implications in biofilm formation in selected clinical and commensal Staphylococcus epidermidis isolates. MATERIAL & METHODS:Isolates were analyzed regarding their biofilm-forming capacity, biochemical matrix composition, biofilm spati...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2017-0140

    authors: Freitas AI,Lopes N,Oliveira F,Brás S,França Â,Vasconcelos C,Vilanova M,Cerca N

    更新日期:2018-03-01 00:00:00

  • Genetic and population analyses of Vibrio parahaemolyticus isolates from three major coastal regions in China.

    abstract:AIM:This study aims to evaluate the genetic and population structure of Vibrio parahaemolyticus in the major coastal regions of China. MATERIALS & METHODS:Multilocus sequence typing was performed. RESULTS:Insertion of large sequence into recA happened in nearly 30 strains, which were untypeable by multilocus sequence...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0060

    authors: Li P,Xin W,Kang L,Chen Z,Guo C,Gao S,Yang H,Ji B,Yan Y,Wang H,Zhou D,Yang W,Wang J

    更新日期:2018-09-01 00:00:00

  • Inhibition of growth and gene expression in Staphylococcus aureus by anti-gyrA peptide nucleic acid.

    abstract::Aim: Multidrug-resistant Staphylococcus aureus isolates have become a serious concern in clinical microbiology. Antisense strategy, which specifically targets essential genes, could be helpful. Materials & methods:S. aureus cultures were treated with peptide conjugate-peptide nucleic acid (PPNA) specific for the gyrA ...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2019-0103

    authors: Tavakoli M,Hashemi A,Vaezjalali M,Mohammadzadeh M,Goudarzi H

    更新日期:2019-09-01 00:00:00

  • Genetics of Coxiella burnetii: on the path of specialization.

    abstract::Coxiella burnetii is an extremely infectious, zoonotic agent that causes Q fever in humans. With the exception of New Zealand, the bacterium is distributed worldwide. Coxiella is classified as a select agent based on its past and potential use as a bioweapon and its threat to public health. Despite decades of research...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.11.116

    authors: Minnick MF,Raghavan R

    更新日期:2011-11-01 00:00:00

  • Potential impact of removing metronidazole from treatment armamentarium of mild acute Clostridioides difficile infection.

    abstract::Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2019-0157

    authors: Zilberman-Itskovich S,Youngster I,Lazarovitch T,Bondarenco M,Toledano L,Kachlon Y,Mengesha B,Strul N,Zaidenstein R,Marchaim D

    更新日期:2019-11-01 00:00:00

  • Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy.

    abstract::Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.12.9

    authors: Rolando M,Buchrieser C

    更新日期:2012-03-01 00:00:00

  • In vitro susceptibility testing in Aspergillus species: an update.

    abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.34

    authors: Lass-Flörl C

    更新日期:2010-05-01 00:00:00

  • γ-irradiation from radiotherapy improves the virulence potential of Candida tropicalis.

    abstract:AIM:To evaluate if radiation used in radiotherapy can cause changes in the virulence potential of Candida tropicalis ATCC 750. MATERIALS & METHODS:C. tropicalis was exposed in vitro to identical dose and scheme of irradiation would be used in patients with head and neck cancer. Some virulence parameters were analyzed ...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2017-0137

    authors: da Silva EM,Kischkel B,Shinobu-Mesquita CS,Bonfim-Mendonça PS,Mansano ES,da Silva MA,Barbosa JF,Fiorini A,Hernandes L,Furlaneto MC,Svidzinski TI

    更新日期:2017-12-01 00:00:00

  • The contribution of genomics to the study of Q fever.

    abstract::Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.15.137

    authors: D'Amato F,Eldin C,Raoult D

    更新日期:2016-01-01 00:00:00

  • Cryptococcal infections in children: retrospective study and review from Australia.

    abstract::Aim: Cryptococcosis causes significant morbidity and mortality worldwide, but pediatric data are limited. Methods: A retrospective literature review of Australian pediatric cryptococcosis and additional 10-year audit of cases from a large pediatric network. Results: 22 cases of cryptococcosis in children were identifi...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb-2019-0215

    authors: Grimshaw A,Palasanthiran P,Huynh J,Marais B,Chen S,McMullan B

    更新日期:2019-12-01 00:00:00

  • Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder in Candida albicans.

    abstract:AIM:Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans. MATERIALS & METHODS:A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The functio...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2017-0098

    authors: Zhang D,Dong Y,Yu Q,Kai Z,Zhang M,Jia C,Xiao C,Zhang B,Zhang B,Li M

    更新日期:2017-11-01 00:00:00

  • Protective host immune responses to Salmonella infection.

    abstract::Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.14.98

    authors: Pham OH,McSorley SJ

    更新日期:2015-01-01 00:00:00