Safety, tolerability and pharmacokinetics of AFN-1252 administered as immediate release tablets in healthy subjects.

abstract：:Infections with Pseudomonas aeruginosa are a major health problem, especially for immune-compromised and cystic fibrosis patients, owing to the particular drug resistance of the microorganism. The aim of this review is to provide recent insights into strategies under investigation for prevention and therapy of these i...

journal_title：Future microbiology

authors： Savoia D

更新日期：2014-01-01 00:00:00

abstract：:Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...

journal_title：Future microbiology

authors： Zilberman-Itskovich S,Youngster I,Lazarovitch T,Bondarenco M,Toledano L,Kachlon Y,Mengesha B,Strul N,Zaidenstein R,Marchaim D

更新日期：2019-11-01 00:00:00

abstract：AIM:To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. METHODS:95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. RESULTS:The isolates showed a high diversity (IOD 0.964) w...

journal_title：Future microbiology

authors： Garcia-Nuñez M,Quero S,Pedro-Botet ML,Barrabeig I,Avarez J,Campoy I,Sala MR,Parraga-Niño N,Minguell S,Caylà J,Mateu L,Sabria M

更新日期：2016-07-01 00:00:00

abstract：:The past decade has seen a significant increase in the incidence of invasive fungal infections. The antifungal armamentarium for the treatment of serious fungal infections remains limited. A possible approach to overcoming antifungal drug resistance and high mortality rates seen in severe fungal infections is to combi...

journal_title：Future microbiology

authors： Vazquez JA

更新日期：2007-04-01 00:00:00

abstract：AIM:To compare two identification methods for coagulase-negative staphylococci (CoNS) isolated from patients with urinary tract infections, VITEK® 2 and MALDI-TOF VITEK®MS, with genotypic identification by internal transcribed spacer PCR (ITS-PCR). RESULTS:A total of 217 CoNS isolates were studied. Agreement of the VI...

journal_title：Future microbiology

authors： Martins KB,Ferreira AM,Mondelli AL,Rocchetti TT,Lr de S da Cunha M

更新日期：2018-11-01 00:00:00

abstract：:Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, t...

journal_title：Future microbiology

authors： Eckmann C,Rojas LJ,Lyon S

更新日期：2018-10-01 00:00:00

abstract：:Salmonella enterica is an invasive, facultative intracellular gastrointestinal pathogen causing human diseases such as gastroenteritis and typhoid fever. Virulence-attenuated strains of this pathogen have interesting capacities for the generation of live vaccines. Attenuated live typhoidal and nontyphoidal Salmonella ...

journal_title：Future microbiology

authors： Hegazy WA,Hensel M

更新日期：2012-01-01 00:00:00

abstract：:The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...

journal_title：Future microbiology

authors： Dunn JD,Valdivia RH

更新日期：2010-08-01 00:00:00

abstract：:Helicobacter pylori plays a vital role in the pathogenesis of gastric carcinoma. However, only a relatively small proportion of individuals infected with H. pylori develop gastric carcinoma. Differences in the incidence of gastric carcinoma among infected individuals can be explained, at least partly, by the different...

journal_title：Future microbiology

authors： Wang MY,Liu XF,Gao XZ

更新日期：2015-01-01 00:00:00

abstract：:Capabilities in mass spectrometry are evolving rapidly, with recent improvements in sensitivity, data analysis and, most important from the standpoint of this review, much higher throughput, allowing analysis of many samples in a single day. This short review describes how these improvements in mass spectrometry can b...

journal_title：Future microbiology

authors： Rodland KD,Adkins JN,Ansong C,Chowdhury S,Manes NP,Shi L,Yoon H,Smith RD,Heffron F

更新日期：2008-12-01 00:00:00

abstract：AIM:Presenting the first clinical case of Wickerhamomyces myanmarensis. PATIENTS & METHODS:Yeast cells were isolated from blood and central venous catheter of a 5.5-year-old male subject. API 20C AUX, MALDI-TOF MS, ITS and LSU rDNA sequencing, and our qPCR assay were used for identification and the MIC values were det...

journal_title：Future microbiology

authors： Arastehfar A,Bakhtiari M,Daneshnia F,Fang W,Sadati SK,Al-Hatmi AM,Groenewald M,Sharifi-Mehr H,Liao W,Pan W,Zomorodian K,Hagen F,Boekhout T

更新日期：2019-03-01 00:00:00

abstract：:The recent years have witnessed significant progress in the development of new drug candidates for the treatment of TB. While many of these are now in clinical trials, continued research is needed in order to sustain the drug discovery pipeline and meet the increasing needs of TB patients. These include shortening tre...

journal_title：Future microbiology

authors： Sala C,Hartkoorn RC

更新日期：2011-06-01 00:00:00

abstract：AIM:To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source. MATERIALS & METHODS:The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscop...

journal_title：Future microbiology

authors： Veiga FF,de Castro-Hoshino LV,Sato F,Bombassaro A,Vicente VA,Mendes V,Baesso ML,Negri M,Svidzinski TI

更新日期：2018-12-01 00:00:00

abstract：:Some intracellular/membranous factors exert intrinsic immunity against viral pathogens. Most recently, SAMHD1 has been shown to be one of these factors. SAMHD1 is a nucleus-localized protein, and mutations in the gene are associated with Aicardi-Goutières syndrome. As a triphosphohydrolase, it depletes the intracellul...

journal_title：Future microbiology

authors： Chen Z,Zhang L,Ying S

更新日期：2012-09-01 00:00:00

abstract：:This paper analyzes the most recent reports regarding the direct and indirect effects of the 13-valent pneumococcal conjugate vaccine (PCV13) when administered to infants and young children. PCV13 extends the protective effects reported for the 7-valent pneumococcal conjugate vaccine (PCV7). A further reduction in the...

journal_title：Future microbiology

authors： Esposito S,Principi N,ESCMID Vaccine Study Group.

更新日期：2015-01-01 00:00:00

abstract：:Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. Methods: Twenty-eight nonduplicate CRAB isolates detected a...

journal_title：Future microbiology

authors： Osman M,B Halimeh F,Rafei R,Mallat H,Tom JE,Raad EB,M Diene S,Jamal S,Atrouni AA,Dabboussi F,Moudani W,Madec JY,Saras E,Lupo A,Haenni M,Rolain JM,Hamze M

更新日期：2020-10-01 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus) is a major global cause of human disease. Since the publication of the entire sequence of TIGR4 in 2001, our understanding of this human pathogen has increased significantly. Genetic studies, and the use of mutant strains have refined our understanding of the pathogenic mech...

journal_title：Future microbiology

authors： Preston JA,Dockrell DH

更新日期：2008-04-01 00:00:00

abstract：:Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...

journal_title：Future microbiology

authors： A Castaneda C,Castillo M,Sanchez J,Casavilca S,Sanchez J,A Bernabe L,Suarez N,Chavez I,Ruiz E,Tello K,R Villa M,Zevallos R,Montenegro P,Dias-Neto E,Landa-Baella M,Taxa L

更新日期：2020-08-01 00:00:00

abstract：:A multidisplay vaccine delivery system has been developed that is nonreplicating and has a protein-based particulate structure. The structure is composed of helical tubules comprising multiple copies of a single nonstructural (NS) protein 1 of bluetongue virus. The helical assemblies present the C terminus of the prot...

journal_title：Future microbiology

authors： Murphy A,Roy P

更新日期：2008-06-01 00:00:00

abstract：:Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genoty...

journal_title：Future microbiology

authors： Dalton HR,Kamar N,Izopet J

更新日期：2014-01-01 00:00:00

abstract：AIM:Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS:We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (...

journal_title：Future microbiology

authors： Sharma S,Dahiya B,Sreenivas V,Singh N,Raj A,Sheoran A,Yadav A,Gupta KB,Mehta PK

更新日期：2018-03-01 00:00:00

abstract：AIM:To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. MATERIALS & METHODS:A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract i...

journal_title：Future microbiology

authors： Zhu T,Lu QB,Zhang SY,Wo Y,Zhuang L,Zhang PH,Zhang XA,Wei W,Liu W

更新日期：2017-05-01 00:00:00

abstract：:In the past few months, there has been public discussion relating to a new perspective on blood safety and specifically upon measures to prevent or discourage donation by individuals with a diagnosis of myalgic encephalopathy-chronic fatigue syndrome. This reflects an intriguing interplay between science, public healt...

journal_title：Future microbiology

authors： Dodd RY

更新日期：2011-04-01 00:00:00

abstract：:The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A m...

journal_title：Future microbiology

authors： Cohen A,Bont L,Engelhard D,Moore E,Fernández D,Kreisberg-Greenblatt R,Oved K,Eden E,Hays JP

更新日期：2015-01-01 00:00:00

abstract：:Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...

journal_title：Future microbiology

authors： Tovy A,Ankri S

更新日期：2010-12-01 00:00:00

abstract：:The genus Asaia has gained much interest lately owing to constant new species discoveries and its role as a potential opportunistic pathogen to humans. Here we describe a transient bacteremia due to Asaia lannensis in a patient with a psychiatric disorder (compulsive self-injection of different substances). Common phe...

journal_title：Future microbiology

authors： Carretto E,Visiello R,Bardaro M,Schivazappa S,Vailati F,Farina C,Barbarini D

更新日期：2016-01-01 00:00:00

abstract：:Among the 33 confirmed Bartonella species to date, more than half are hosted by rodent species, and at least five of them have been involved in human illness causing diverse symptoms including fever, myocarditis, endocarditis, lymphadenitis and hepatitis. In almost all countries, wild rodents are infected by extremely...

journal_title：Future microbiology

authors： Buffet JP,Kosoy M,Vayssier-Taussat M

更新日期：2013-09-01 00:00:00

abstract：:Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies includin...

journal_title：Future microbiology

authors： Kato-Maeda M,Metcalfe JZ,Flores L

更新日期：2011-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) manifestations remain important complications after allogeneic hematopoietic stem cell transplantation (HSCT), even in the current era. Unfortunately, available anti-CMV agents, mainly viral polymerase inhibitors, have a substantial risk of myelosuppression and nephrotoxicity. Letermovir, a novel...

journal_title：Future microbiology

authors： Hecke SV,Calcoen B,Lagrou K,Maertens J

更新日期：2019-02-01 00:00:00

abstract：:Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review desc...

journal_title：Future microbiology

authors： Mancini N,Marrone L,Clementi N,Sautto GA,Clementi M,Burioni R

更新日期：2015-01-01 00:00:00