Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.

abstract：:Aim: The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical Candida spp. in planktonic and biofilm form. Materials & methods: The antifungal activity was observed using the broth microdilution technique. Flow cytometry tests we...

journal_title：Future microbiology

authors： Holanda MA,da Silva CR,de A Neto JB,do Av Sá LG,do Nascimento FB,Barroso DD,da Silva LJ,Cândido TM,Leitão AC,Barbosa AD,de Moraes MO,Cc B,Júnior HVN

更新日期：2021-01-01 00:00:00

abstract：AIM:To evaluate if radiation used in radiotherapy can cause changes in the virulence potential of Candida tropicalis ATCC 750. MATERIALS & METHODS:C. tropicalis was exposed in vitro to identical dose and scheme of irradiation would be used in patients with head and neck cancer. Some virulence parameters were analyzed ...

journal_title：Future microbiology

authors： da Silva EM,Kischkel B,Shinobu-Mesquita CS,Bonfim-Mendonça PS,Mansano ES,da Silva MA,Barbosa JF,Fiorini A,Hernandes L,Furlaneto MC,Svidzinski TI

更新日期：2017-12-01 00:00:00

abstract：:The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in tropical and devel...

journal_title：Future microbiology

authors： Herrmann M,Abdullah S,Alabi A,Alonso P,Friedrich AW,Fuhr G,Germann A,Kern WV,Kremsner PG,Mandomando I,Mellmann AC,Pluschke G,Rieg S,Ruffing U,Schaumburg F,Tanner M,Peters G,von Briesen H,von Eiff C,von Müller L,Gr

更新日期：2013-01-01 00:00:00

abstract：:Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...

journal_title：Future microbiology

authors： Minandri F,Bonchi C,Frangipani E,Imperi F,Visca P

更新日期：2014-01-01 00:00:00

abstract：AIM:Invasive fungal infections pose a severe health threat to patients. Despite recent advances in drug development, treatment of recurrent fungal infections remains difficult. Posaconazole is a broad-spectrum triazole antifungal drug available for oral administration. Although initial studies have described its use in...

journal_title：Future microbiology

authors： Huang X,Wang F,Chen Y,Liu T,Wang J,Hu J,Jie J,Chen F,Wang S,Shen Z,Yu L,Yu K,Liang Y

更新日期：2012-02-01 00:00:00

abstract：:Traditionally, the patients believed to be at highest risk of invasive aspergillosis (IA) are those who are neutropenic due to chemotherapy for hematological malignancy or those undergoing allogeneic hematopoietic stem cell transplantation. However, emerging data show that other patients are vulnerable to IA, even tho...

journal_title：Future microbiology

authors： Sheppard D,Grist LM

更新日期：2010-07-01 00:00:00

abstract：:Cooling towers provide a favorable environment for the proliferation of microorganisms. Cooling towers generate a biofilm and often aerosolize contaminated water, thereby increasing the risk of microorganism dissemination by human inhalation. This pathogen dissemination was first revealed by the epidemics of Legionnai...

journal_title：Future microbiology

authors： Pagnier I,Merchat M,La Scola B

更新日期：2009-06-01 00:00:00

abstract：:Recognition of bacterial infection is the first key step to the initiation of an inflammatory response and host defense. Transmembrane proteins of the Toll-like receptor family have long been recognized as key detectors of the extracellular presence of pathogens. Recently, much research has identified a variety of int...

journal_title：Future microbiology

authors： Evans TJ

更新日期：2009-02-01 00:00:00

abstract：:Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of...

journal_title：Future microbiology

authors： D'Amato F,Eldin C,Raoult D

更新日期：2016-01-01 00:00:00

abstract：:HCV is a major cause of chronic liver disease worldwide. There is no vaccine available and the current antiviral therapies fail to cure approximately half of treated patients. Liver disease caused by HCV infection is the most common indication for orthotopic liver transplantation. Unfortunately, reinfection of the new...

journal_title：Future microbiology

authors： Angus AG,Patel AH

更新日期：2011-03-01 00:00:00

abstract：:Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...

journal_title：Future microbiology

authors： A Castaneda C,Castillo M,Sanchez J,Casavilca S,Sanchez J,A Bernabe L,Suarez N,Chavez I,Ruiz E,Tello K,R Villa M,Zevallos R,Montenegro P,Dias-Neto E,Landa-Baella M,Taxa L

更新日期：2020-08-01 00:00:00

abstract：:Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-imp...

journal_title：Future microbiology

authors： van der Eijk AA,Tintu AN,Hays JP

更新日期：2017-01-01 00:00:00

abstract：:Aim: Antibiotic resistance in Mycobacterium abscessus renders treatment poorly effective. Despite erm(41)-gene-mediated macrolide resistance, treatment with azithromycin or clarithromycin is recommended. It is contested whether macrolides differ in erm(41) induction. We determine whether this is the case. Methods:M. a...

journal_title：Future microbiology

authors： Schildkraut JA,Pennings LJ,Ruth MM,de Brouwer AP,Wertheim HF,Hoefsloot W,de Jong A,van Ingen J

更新日期：2019-06-01 00:00:00

abstract：AIM:Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS:We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (...

journal_title：Future microbiology

authors： Sharma S,Dahiya B,Sreenivas V,Singh N,Raj A,Sheoran A,Yadav A,Gupta KB,Mehta PK

更新日期：2018-03-01 00:00:00

abstract：:Helicobacter pylori plays a vital role in the pathogenesis of gastric carcinoma. However, only a relatively small proportion of individuals infected with H. pylori develop gastric carcinoma. Differences in the incidence of gastric carcinoma among infected individuals can be explained, at least partly, by the different...

journal_title：Future microbiology

authors： Wang MY,Liu XF,Gao XZ

更新日期：2015-01-01 00:00:00

abstract：:During coevolution with their hosts, bacteria have developed functions that allow them to interfere with the mechanisms controlling the proliferation of eukaryotic cells. Cycle inhibiting factor (Cif) is one of these cyclomodulins, the family of bacterial effectors that interfere with the host cell cycle. Acquired ear...

journal_title：Future microbiology

authors： Samba-Louaka A,Taieb F,Nougayrède JP,Oswald E

更新日期：2009-09-01 00:00:00

abstract：AIM:The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS:Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly a...

journal_title：Future microbiology

authors： Marchaim D,Levit D,Zigron R,Gordon M,Lazarovitch T,Carrico JA,Chalifa-Caspi V,Moran-Gilad J

更新日期：2017-03-01 00:00:00

abstract：:West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...

journal_title：Future microbiology

authors： Ulbert S,Magnusson SE

更新日期：2014-01-01 00:00:00

abstract：AIM:This study aims to evaluate the genetic and population structure of Vibrio parahaemolyticus in the major coastal regions of China. MATERIALS & METHODS:Multilocus sequence typing was performed. RESULTS:Insertion of large sequence into recA happened in nearly 30 strains, which were untypeable by multilocus sequence...

journal_title：Future microbiology

authors： Li P,Xin W,Kang L,Chen Z,Guo C,Gao S,Yang H,Ji B,Yan Y,Wang H,Zhou D,Yang W,Wang J

更新日期：2018-09-01 00:00:00

abstract：:Aim: To investigate the action mechanism of 1-benzyl-1,4-diazepane (1-BD) as efflux pump inhibitor (EPI) in Escherichia coli mutants: ΔacrAB or overexpressing AcrAB and AcrEF efflux pumps. Materials & methods: Effect of 1-BD on: antibiotic potentiation, by microdilution method; membrane functionality, by fluorimetric ...

journal_title：Future microbiology

authors： Casalone E,Vignolini T,Braconi L,Gardini L,Capitanio M,Pavone FS,Dei S,Teodori E

更新日期：2020-07-01 00:00:00

abstract：AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached w...

journal_title：Future microbiology

authors： Román E,Huertas B,Prieto D,Díez-Orejas R,Pla J

更新日期：2018-06-01 00:00:00

abstract：:Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We us...

journal_title：Future microbiology

authors： Corrêa-Moreira D,De Luca PM,Romeo O,C Menezes R,Paes RA,Oliveira RZ,de Moraes AM,de L Neto RG,Moraes Borba C,E de Oliveira MM

更新日期：2020-09-01 00:00:00

abstract：AIMS:Nosocomial infections cause significant morbidity and mortality in cancer patients. As a result of their debilitated immune system, cancer patients are likely candidates for colonization with anaerobes. We sought to compare the distribution of nosocomial infections in neutropenic and non-neutropenic cancer patient...

journal_title：Future microbiology

authors： El-Sharif A,Elkhatib WF,Ashour HM

更新日期：2012-12-01 00:00:00

abstract：AIM:To assess different concentrations and formulations of topical ozenoxacin using a mouse model of Staphylococcus aureus dermal infection for identification of the best formulation for treating patients with impetigo. MATERIALS & METHODS:The efficacy of ozenoxacin formulations was compared with vehicle control, mupi...

journal_title：Future microbiology

authors： Tarragó C,Esquirol LP,Arañó A,Lachamp L,D'Aniello F,Zsolt I

更新日期：2018-05-01 00:00:00

abstract：:Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, t...

journal_title：Future microbiology

authors： Eckmann C,Rojas LJ,Lyon S

更新日期：2018-10-01 00:00:00

abstract：:Aim: Bile salts promote the specific autolysis of pneumococcal cells, allowing the differentiation between Streptococcus pneumoniae and other viridans group streptococci (VGS). Material & methods: One hundred clinical VGS isolates identified by amplification and sequencing of 16S rRNA, groEL and sodA genes were analyz...

journal_title：Future microbiology

authors： Ercibengoa M,Morales M,Alonso M,Ardanuy C,Marimón JM

更新日期：2019-07-01 00:00:00

abstract：AIM:Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans. MATERIALS & METHODS:A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The functio...

journal_title：Future microbiology

authors： Zhang D,Dong Y,Yu Q,Kai Z,Zhang M,Jia C,Xiao C,Zhang B,Zhang B,Li M

更新日期：2017-11-01 00:00:00

abstract：:Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-formi...

journal_title：Future microbiology

authors： Cai X,Kong F,Wang R,Zhai S,Guan X,Zhang G,Wang D

更新日期：2019-07-01 00:00:00

abstract：:Temporal and spatial fluctuations in the genotype distribution of human rotaviruses are continuously observed in surveillance studies. New genotypes, such as G9 and G12, have emerged and spread worldwide in a very short time span. In addition, reassortment events have the potential to contribute substantially to genet...

journal_title：Future microbiology

authors： Matthijnssens J,Bilcke J,Ciarlet M,Martella V,Bányai K,Rahman M,Zeller M,Beutels P,Van Damme P,Van Ranst M

更新日期：2009-12-01 00:00:00

abstract：:Aim: Cryptococcosis causes significant morbidity and mortality worldwide, but pediatric data are limited. Methods: A retrospective literature review of Australian pediatric cryptococcosis and additional 10-year audit of cases from a large pediatric network. Results: 22 cases of cryptococcosis in children were identifi...

journal_title：Future microbiology

authors： Grimshaw A,Palasanthiran P,Huynh J,Marais B,Chen S,McMullan B

更新日期：2019-12-01 00:00:00