Manipulation of the bluetongue virus tubules for immunogen delivery.

abstract：:Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogen...

journal_title：Future microbiology

authors： Narra HP,Sahni A,Walker DH,Sahni SK

更新日期：2020-06-01 00:00:00

abstract：:Aim: To investigate the action mechanism of 1-benzyl-1,4-diazepane (1-BD) as efflux pump inhibitor (EPI) in Escherichia coli mutants: ΔacrAB or overexpressing AcrAB and AcrEF efflux pumps. Materials & methods: Effect of 1-BD on: antibiotic potentiation, by microdilution method; membrane functionality, by fluorimetric ...

journal_title：Future microbiology

authors： Casalone E,Vignolini T,Braconi L,Gardini L,Capitanio M,Pavone FS,Dei S,Teodori E

更新日期：2020-07-01 00:00:00

abstract：:Micafungin is a new drug in the echinocandin class and is currently being investigated in Phase III clinical trials. Like other echinocandins, it inhibits 1,3-beta-D-glucan synthesis, thus achieving fungicidal activity against virtually all Candida spp., including those resistant to fluconazole, and fungistatic activi...

journal_title：Future microbiology

authors： Vehreschild JJ,Cornely OA

更新日期：2006-08-01 00:00:00

abstract：AIM:The purpose of current study is to find out relationship between cas9 gene and antimicrobial resistance in Campylobacter jejuni NCTC11168. MATERIALS & METHODS:The involvement of the cas9 gene in antimicrobial resistance of C. jejuni was determined by assessment of minimum inhibitory concentration, clustered regula...

journal_title：Future microbiology

authors： Shabbir MA,Wu Q,Shabbir MZ,Sajid A,Ahmed S,Sattar A,Tang Y,Li J,Maan MK,Hao H,Yuan Z

更新日期：2018-12-01 00:00:00

abstract：AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...

journal_title：Future microbiology

authors： Xu S,Yang J,Yin C,Zhao X

更新日期：2018-02-01 00:00:00

abstract：:Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which ...

journal_title：Future microbiology

authors： Tseng HK,Huang TY,Wu AY,Chen HH,Liu CP,Jong A

更新日期：2015-01-01 00:00:00

abstract：:Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-formi...

journal_title：Future microbiology

authors： Cai X,Kong F,Wang R,Zhai S,Guan X,Zhang G,Wang D

更新日期：2019-07-01 00:00:00

abstract：:Evaluation of: Mowat E, Butcher J, Lang S, Williams C, Ramage G: Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus. J. Med. Microbiol. 56, 1205-1212 (2007). Many microorganisms possess the innate ability for adhering to biotic and abiotic ...

journal_title：Future microbiology

authors： Chandrasekar PH,Manavathu EK

更新日期：2008-02-01 00:00:00

abstract：AIM:A DNA microarray-based assay for the detection of antimicrobial resistance (AMR) genes was used to study carbapenemase-producing organisms at the Kidney Center of Rawalpindi, Pakistan. METHODS:The evaluation of this assay was performed using 97 reference strains with confirmed AMR genes. Testing of 7857 clinical s...

journal_title：Future microbiology

authors： Braun SD,Jamil B,Syed MA,Abbasi SA,Weiß D,Slickers P,Monecke S,Engelmann I,Ehricht R

更新日期：2018-09-01 00:00:00

abstract：:Malaria remains a major international health challenge. Resistance to a number of existing drugs and evidence of the emergence of artemisinin resistance has emphasized the need for new antimalarials. A new approach has been the preparation of dual-function compounds that include a chloroquine-like antimalarial group a...

journal_title：Future microbiology

authors： Egan TJ,Kuter D

更新日期：2013-04-01 00:00:00

abstract：:In the past few months, there has been public discussion relating to a new perspective on blood safety and specifically upon measures to prevent or discourage donation by individuals with a diagnosis of myalgic encephalopathy-chronic fatigue syndrome. This reflects an intriguing interplay between science, public healt...

journal_title：Future microbiology

authors： Dodd RY

更新日期：2011-04-01 00:00:00

abstract：:Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might ...

journal_title：Future microbiology

authors： Gouzy A,Poquet Y,Neyrolles O

更新日期：2014-01-01 00:00:00

abstract：:Atomic force microscopy (AFM) has recently opened a variety of novel possibilities for imaging and manipulating microbial surfaces in their native environment. While AFM imaging offers a means to visualize surface structures at high resolution and in physiological conditions, AFM force spectroscopy enables researchers...

journal_title：Future microbiology

authors： Dufrêne YF

更新日期：2006-12-01 00:00:00

abstract：AIM:Invasive fungal infections pose a severe health threat to patients. Despite recent advances in drug development, treatment of recurrent fungal infections remains difficult. Posaconazole is a broad-spectrum triazole antifungal drug available for oral administration. Although initial studies have described its use in...

journal_title：Future microbiology

authors： Huang X,Wang F,Chen Y,Liu T,Wang J,Hu J,Jie J,Chen F,Wang S,Shen Z,Yu L,Yu K,Liang Y

更新日期：2012-02-01 00:00:00

abstract：AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) rende...

journal_title：Future microbiology

authors： Correia I,Román E,Prieto D,Eisman B,Pla J

更新日期：2016-01-01 00:00:00

abstract：:Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

journal_title：Future microbiology

authors： Feldman C,Anderson R

更新日期：2006-10-01 00:00:00

abstract：:Aim: Bile salts promote the specific autolysis of pneumococcal cells, allowing the differentiation between Streptococcus pneumoniae and other viridans group streptococci (VGS). Material & methods: One hundred clinical VGS isolates identified by amplification and sequencing of 16S rRNA, groEL and sodA genes were analyz...

journal_title：Future microbiology

authors： Ercibengoa M,Morales M,Alonso M,Ardanuy C,Marimón JM

更新日期：2019-07-01 00:00:00

abstract：:The aggregate of microorganisms residing on the surface of the skin, in the oropharynx and in the GI tract, known as the human microbiota, play a major role as natural reservoirs for bacterial resistance to antibiotics. Fluoroquinolones (FQ) are among the most prescribed antibiotics and a major increase in FQ resistan...

journal_title：Future microbiology

authors： de Lastours V,Fantin B

更新日期：2015-01-01 00:00:00

abstract：:Surgical procedures for the symptomatic removal of the gallbladder and the vermiform appendix have been posited to adversely shift the assemblage of the intestinal microbiome increasing the risk of disease. The associated mechanisms have been linked with dysbiosis of the gut microbiota. Cholecystectomy causes changes ...

journal_title：Future microbiology

authors： Chen J,Sali A,Vitetta L

更新日期：2020-05-01 00:00:00

abstract：:Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...

journal_title：Future microbiology

authors： Rivera-Chaparro ND,Cohen-Wolkowiez M,Greenberg RG

更新日期：2017-09-01 00:00:00

abstract：AIM:To assess different concentrations and formulations of topical ozenoxacin using a mouse model of Staphylococcus aureus dermal infection for identification of the best formulation for treating patients with impetigo. MATERIALS & METHODS:The efficacy of ozenoxacin formulations was compared with vehicle control, mupi...

journal_title：Future microbiology

authors： Tarragó C,Esquirol LP,Arañó A,Lachamp L,D'Aniello F,Zsolt I

更新日期：2018-05-01 00:00:00

abstract：AIMS:Nosocomial infections cause significant morbidity and mortality in cancer patients. As a result of their debilitated immune system, cancer patients are likely candidates for colonization with anaerobes. We sought to compare the distribution of nosocomial infections in neutropenic and non-neutropenic cancer patient...

journal_title：Future microbiology

authors： El-Sharif A,Elkhatib WF,Ashour HM

更新日期：2012-12-01 00:00:00

abstract：:Using the murine CMV animal model and the well-established model of Cre-lox-P-mediated green-fluorescence tagging of endothelial cell (EC)-derived mouse CMV to quantify the role of infected ECs in transplantation-associated CMV dissemination (in mice expressing Cre recombinase under the control of either the Tie2 or t...

journal_title：Future microbiology

authors： Gerna G

更新日期：2012-04-01 00:00:00

abstract：:Aim: In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. Materials & methods: If subjects presented with febrile symptoms at the ED, 13 biomarkers' levels, including CD64 on neutrophils (n...

journal_title：Future microbiology

authors： Bourgoin P,Lediagon G,Arnoux I,Bernot D,Morange PE,Michelet P,Malergue F,Markarian T

更新日期：2020-02-01 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus) is a major global cause of human disease. Since the publication of the entire sequence of TIGR4 in 2001, our understanding of this human pathogen has increased significantly. Genetic studies, and the use of mutant strains have refined our understanding of the pathogenic mech...

journal_title：Future microbiology

authors： Preston JA,Dockrell DH

更新日期：2008-04-01 00:00:00

abstract：:Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...

journal_title：Future microbiology

authors： Pich OQ,Merrell DS

更新日期：2013-06-01 00:00:00

abstract：:This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...

journal_title：Future microbiology

authors： Taylor J,Pelchat M

更新日期：2010-03-01 00:00:00

abstract：:Capabilities in mass spectrometry are evolving rapidly, with recent improvements in sensitivity, data analysis and, most important from the standpoint of this review, much higher throughput, allowing analysis of many samples in a single day. This short review describes how these improvements in mass spectrometry can b...

journal_title：Future microbiology

authors： Rodland KD,Adkins JN,Ansong C,Chowdhury S,Manes NP,Shi L,Yoon H,Smith RD,Heffron F

更新日期：2008-12-01 00:00:00

abstract：AIMS:The aim of the study was to evaluate epidemiology and susceptibility patterns of nosocomial Gram-positive infections in a referral teaching hospital. METHODS:Over a 1 year period, Gram-positive microorganisms isolated from specimens of hospitalized patients with documented nosocomial infection underwent antimicro...

journal_title：Future microbiology

authors： Soltani R,Khalili H,Abdollahi A,Rasoolinejad M,Dashti-Khavidaki S

更新日期：2012-07-01 00:00:00

abstract：:Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from...

journal_title：Future microbiology

authors： Ward H,Tang L,Poonia B,Kottilil S

更新日期：2016-12-01 00:00:00