Abstract:
:Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blindness in industrialized nations. Neuronal latency in the peripheral ganglia is established when transcription of the viral genome is repressed (silenced) except for the latency-associated transcripts and microRNAs. The functions of latency-associated transcripts have been investigated since 1987. Roles have been suggested relating to reactivation, establishment of latency, neuronal protection, antiapoptosis, apoptosis, virulence and asymptomatic shedding. Here, we review HSV-1 latent infections, reactivation, recurrent disease and antiviral therapies for the ocular HSV diseases.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Al-Dujaili LJ,Clerkin PP,Clement C,McFerrin HE,Bhattacharjee PS,Varnell ED,Kaufman HE,Hill JMdoi
10.2217/fmb.11.73subject
Has Abstractpub_date
2011-08-01 00:00:00pages
877-907issue
8eissn
1746-0913issn
1746-0921journal_volume
6pub_type
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更新日期:2010-12-01 00:00:00
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更新日期:2007-12-01 00:00:00
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更新日期:2016-01-01 00:00:00
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