Salmonella enterica as a vaccine carrier.


:Salmonella enterica is an invasive, facultative intracellular gastrointestinal pathogen causing human diseases such as gastroenteritis and typhoid fever. Virulence-attenuated strains of this pathogen have interesting capacities for the generation of live vaccines. Attenuated live typhoidal and nontyphoidal Salmonella strains can be used for vaccination against Salmonella infections and to target tumor tissue. Such strains may also serve as live carriers for the development of vaccination strategies against other bacterial, viral or parasitic pathogens. Various strategies have been developed to deploy regulatory circuits and protein secretion systems for efficient expression and delivery of foreign antigens by Salmonella carrier strains. One prominent example is the use of type III secretion systems to translocate recombinant antigens into antigen presenting cells. In this review, we will describe the recent developments in strategies that utilize live attenuated Salmonella as vaccine carriers for prophylactic vaccination against infectious diseases and therapeutic vaccination against tumors. Considerations for generating safe, attenuated carrier strains, designing stable expression systems and the use of adjuvants for live carrier strategies are discussed.


Future Microbiol


Future microbiology


Hegazy WA,Hensel M




Has Abstract


2012-01-01 00:00:00












  • Direct and indirect effects of the 13-valent pneumococcal conjugate vaccine administered to infants and young children.

    abstract::This paper analyzes the most recent reports regarding the direct and indirect effects of the 13-valent pneumococcal conjugate vaccine (PCV13) when administered to infants and young children. PCV13 extends the protective effects reported for the 7-valent pneumococcal conjugate vaccine (PCV7). A further reduction in the...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Esposito S,Principi N,ESCMID Vaccine Study Group.

    更新日期:2015-01-01 00:00:00

  • First fungemia case due to environmental yeast Wickerhamomyces myanmarensis: detection by multiplex qPCR and antifungal susceptibility.

    abstract:AIM:Presenting the first clinical case of Wickerhamomyces myanmarensis. PATIENTS & METHODS:Yeast cells were isolated from blood and central venous catheter of a 5.5-year-old male subject. API 20C AUX, MALDI-TOF MS, ITS and LSU rDNA sequencing, and our qPCR assay were used for identification and the MIC values were det...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Arastehfar A,Bakhtiari M,Daneshnia F,Fang W,Sadati SK,Al-Hatmi AM,Groenewald M,Sharifi-Mehr H,Liao W,Pan W,Zomorodian K,Hagen F,Boekhout T

    更新日期:2019-03-01 00:00:00

  • Evaluation of different microtiter plate-based methods for the quantitative assessment of Staphylococcus aureus biofilms.

    abstract:AIM:To quantitatively assess Staphylococcus aureus biofilms. MATERIALS & METHODS:In addition to the qualitative Congo red agar (CRA) method, we used the bioluminescence (BLM), safranine (SAF), crystal violet (CRV) and resazurin (RES) high-throughput microtiter plate-based quantitative assays. RESULTS:60.47% (26/43) o...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Elkhatib WF,Khairalla AS,Ashour HM

    更新日期:2014-01-01 00:00:00

  • Potential for adaptation overrides cost of resistance.

    abstract:AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolution...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Moura de Sousa J,Sousa A,Bourgard C,Gordo I

    更新日期:2015-01-01 00:00:00

  • Inhibition of growth and gene expression in Staphylococcus aureus by anti-gyrA peptide nucleic acid.

    abstract::Aim: Multidrug-resistant Staphylococcus aureus isolates have become a serious concern in clinical microbiology. Antisense strategy, which specifically targets essential genes, could be helpful. Materials & methods:S. aureus cultures were treated with peptide conjugate-peptide nucleic acid (PPNA) specific for the gyrA ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tavakoli M,Hashemi A,Vaezjalali M,Mohammadzadeh M,Goudarzi H

    更新日期:2019-09-01 00:00:00

  • Antibiotic resistance: challenges and successes in respiratory infection.

    abstract::European Respiratory Society Congress, Amsterdam, 26-30 September 2015, and CHEST 2015, Montréal, Canada, 24-28 October 2015 With approximately 50,000 deaths in the US and EU attributed to antibacterial resistance each year, together with several million days of hospital care [1], the need to address resistance mechan...

    journal_title:Future microbiology



    authors: Sethi S,Bryan J

    更新日期:2016-01-01 00:00:00

  • Septic patients in the intensive care unit present different nasal microbiotas.

    abstract:AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dom...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tan XL,Liu HY,Long J,Jiang Z,Luo Y,Zhao X,Cai S,Zhong X,Cen Z,Su J,Zhou H

    更新日期:2019-03-01 00:00:00

  • Effects of hyperbaric oxygen on Pseudomonas aeruginosa susceptibility to imipenem and macrophages.

    abstract:BACKGROUND:The seriousness to treat burn wounds infected with Pseudomonas aeruginosa led us to examine whether the effect of the carbapenem antibiotic imipenem is enhanced by hyperbaric oxygen (HBO). MATERIALS & METHODS:The effects of HBO (100% O2, 3 ATA, 5 h) in combination with imipenen on bacterial counts of six is...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Lima FL,Joazeiro PP,Lancellotti M,de Hollanda LM,de Araújo Lima B,Linares E,Augusto O,Brocchi M,Giorgio S

    更新日期:2015-01-01 00:00:00

  • The impact of intestinal microbiota on weight loss in Parkinson's disease patients: a pilot study.

    abstract::Background: There is increasing evidence of the association between microbiome dysfunction and Parkinson's disease (PD). Moreover, some PD patients suffer from unintentional weight loss (WL) which may precede the motor manifestations of the disease. Materials & methods: Gut microbiota profiling by 16S rRNA gene sequen...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Del Chierico F,Grassini P,Quagliariello A,Torti M,Russo A,Reddel S,Stocchi F

    更新日期:2020-09-01 00:00:00

  • Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy.

    abstract::Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rolando M,Buchrieser C

    更新日期:2012-03-01 00:00:00

  • The gut microbiome and the potentials of probiotics: an interview with Simon Gaisford.

    abstract::In this exclusive interview, Simon Gaisford discusses his current research into gut dysbiosis and its possible relevance to disease states, as well as the efficacy of probiotic supplementation and its possible use as treatment. This interview was conducted by Ellen Colvin, Commissioning Editor of Future Microbiology. ...

    journal_title:Future microbiology

    pub_type: 面试


    authors: Gaisford S

    更新日期:2019-03-01 00:00:00

  • Nanoscale exploration of microbial surfaces using the atomic force microscope.

    abstract::Atomic force microscopy (AFM) has recently opened a variety of novel possibilities for imaging and manipulating microbial surfaces in their native environment. While AFM imaging offers a means to visualize surface structures at high resolution and in physiological conditions, AFM force spectroscopy enables researchers...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Dufrêne YF

    更新日期:2006-12-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • New perspectives in the management of Pseudomonas aeruginosa infections.

    abstract::Infections with Pseudomonas aeruginosa are a major health problem, especially for immune-compromised and cystic fibrosis patients, owing to the particular drug resistance of the microorganism. The aim of this review is to provide recent insights into strategies under investigation for prevention and therapy of these i...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Savoia D

    更新日期:2014-01-01 00:00:00

  • Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.

    abstract::Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal structures to guide new discovery of antibiotics that are effective aga...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Reeve SM,Lombardo MN,Anderson AC

    更新日期:2015-01-01 00:00:00

  • SAMHD1: a novel antiviral factor in intrinsic immunity.

    abstract::Some intracellular/membranous factors exert intrinsic immunity against viral pathogens. Most recently, SAMHD1 has been shown to be one of these factors. SAMHD1 is a nucleus-localized protein, and mutations in the gene are associated with Aicardi-Goutières syndrome. As a triphosphohydrolase, it depletes the intracellul...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Chen Z,Zhang L,Ying S

    更新日期:2012-09-01 00:00:00

  • Accurate differentiation of novel Staphylococcus argenteus from Staphylococcus aureus using MALDI-TOF MS.

    abstract:AIM:We evaluated a Staphylococcus argenteus-specific diagnostic profile of matrix-assisted laser desorption/ionization time-of-flight mass spectrometer for accurate identification of this novel bacterium. MATERIALS & METHODS:Staphylococcus argenteus was identified based on negative crtM gene and presence of specific s...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Chen SY,Lee H,Teng SH,Wang XM,Lee TF,Huang YC,Liao CH,Teng LJ,Hsueh PR

    更新日期:2018-07-01 00:00:00

  • Cif type III effector protein: a smart hijacker of the host cell cycle.

    abstract::During coevolution with their hosts, bacteria have developed functions that allow them to interfere with the mechanisms controlling the proliferation of eukaryotic cells. Cycle inhibiting factor (Cif) is one of these cyclomodulins, the family of bacterial effectors that interfere with the host cell cycle. Acquired ear...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Samba-Louaka A,Taieb F,Nougayrède JP,Oswald E

    更新日期:2009-09-01 00:00:00

  • Molecular phylogenetics and epidemiology of Candida albicans.

    abstract::Candida albicans, a diploid yeast commensal and opportunist pathogen, has evolved unusual mechanisms for maintenance of genetic diversity in the absence of a complete sexual cycle. These include chromosomal polymorphisms, mitotic recombination events, and gains and losses of heterozygosity, superimposed on a fundament...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Odds FC

    更新日期:2010-01-01 00:00:00

  • Immediate outcomes of bacterial meningitis in childhood may benefit from slow initial β-lactam infusion and oral paracetamol.

    abstract::Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires pro...

    journal_title:Future microbiology

    pub_type: 评论,杂志文章


    authors: Taha MK,Deghmane AE

    更新日期:2011-10-01 00:00:00

  • The composition of intestinal microbiota and its association with functional constipation of the elderly patients.

    abstract::Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were signific...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Guo M,Yao J,Yang F,Liu W,Bai H,Ma J,Ma X,Zhang J,Fang Y,Miao Y,Sun J,Zhang Y,Zhao H

    更新日期:2020-02-01 00:00:00

  • Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead.

    abstract::Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogen...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Narra HP,Sahni A,Walker DH,Sahni SK

    更新日期:2020-06-01 00:00:00

  • Promises and failures of gallium as an antibacterial agent.

    abstract::Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Minandri F,Bonchi C,Frangipani E,Imperi F,Visca P

    更新日期:2014-01-01 00:00:00

  • Detection of Helicobacter pylori in gastric cancer tissue through histopathology, immunohistochemistry and real-time reverse transcription-PCR.

    abstract::Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: A Castaneda C,Castillo M,Sanchez J,Casavilca S,Sanchez J,A Bernabe L,Suarez N,Chavez I,Ruiz E,Tello K,R Villa M,Zevallos R,Montenegro P,Dias-Neto E,Landa-Baella M,Taxa L

    更新日期:2020-08-01 00:00:00

  • Epigenetics in the unicellular parasite Entamoeba histolytica.

    abstract::Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Tovy A,Ankri S

    更新日期:2010-12-01 00:00:00

  • Update on the epidemiological typing methods for Acinetobacter baumannii.

    abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rafei R,Osman M,Dabboussi F,Hamze M

    更新日期:2019-08-01 00:00:00

  • Hepatitis E in developed countries: current status and future perspectives.

    abstract::Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genoty...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Dalton HR,Kamar N,Izopet J

    更新日期:2014-01-01 00:00:00

  • Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in Greece: an extended review (2000-2015).

    abstract::Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest preva...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Karampatakis T,Antachopoulos C,Tsakris A,Roilides E

    更新日期:2017-07-01 00:00:00

  • A multicenter, open-label study of posaconazole oral suspension in the treatment of invasive fungal infections in patients refractory to or intolerant of first-line therapy.

    abstract:AIM:Invasive fungal infections pose a severe health threat to patients. Despite recent advances in drug development, treatment of recurrent fungal infections remains difficult. Posaconazole is a broad-spectrum triazole antifungal drug available for oral administration. Although initial studies have described its use in...

    journal_title:Future microbiology

    pub_type: 杂志文章,多中心研究


    authors: Huang X,Wang F,Chen Y,Liu T,Wang J,Hu J,Jie J,Chen F,Wang S,Shen Z,Yu L,Yu K,Liang Y

    更新日期:2012-02-01 00:00:00

  • Managing invasive fungal disease in immunocompromised patients.

    abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...

    journal_title:Future microbiology



    authors: Maertens J,Bryan J

    更新日期:2010-12-01 00:00:00