Promises and failures of gallium as an antibacterial agent.

abstract：AIM:To investigate the role of Cat1 overproduction in Candida albicans. MATERIALS & METHODS:Strains overproducing the CAT1 gene were constructed. RESULTS:Cells overproducing CAT1 were found to be more resistant to some oxidants and mammalian phagocytic cells. They also showed reduced intracellular reactive oxygen spe...

journal_title：Future microbiology

authors： Román E,Prieto D,Martin R,Correia I,Mesa Arango AC,Alonso-Monge R,Zaragoza O,Pla J

更新日期：2016-10-01 00:00:00

abstract：AIM:The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS:Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly a...

journal_title：Future microbiology

authors： Marchaim D,Levit D,Zigron R,Gordon M,Lazarovitch T,Carrico JA,Chalifa-Caspi V,Moran-Gilad J

更新日期：2017-03-01 00:00:00

abstract：AIMS:The aim of the study was to evaluate epidemiology and susceptibility patterns of nosocomial Gram-positive infections in a referral teaching hospital. METHODS:Over a 1 year period, Gram-positive microorganisms isolated from specimens of hospitalized patients with documented nosocomial infection underwent antimicro...

journal_title：Future microbiology

authors： Soltani R,Khalili H,Abdollahi A,Rasoolinejad M,Dashti-Khavidaki S

更新日期：2012-07-01 00:00:00

abstract：:Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might ...

journal_title：Future microbiology

authors： Gouzy A,Poquet Y,Neyrolles O

更新日期：2014-01-01 00:00:00

abstract：:Diagnostic and treatment delays contribute to increased death and disability among the 490,000 adults and children who develop multidrug-resistant (MDR) tuberculosis every year. Since the treatment of MDR tuberculosis is complex, costly and often toxic, tuberculosis control programs should prioritize strategies to pre...

journal_title：Future microbiology

authors： Byrne AL,Fox GJ,Marais BJ

更新日期：2018-04-01 00:00:00

abstract：:West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...

journal_title：Future microbiology

authors： Ulbert S,Magnusson SE

更新日期：2014-01-01 00:00:00

abstract：:Cryptococcus gattii is an important primary and opportunistic pathogen, predominantly causing meningoencephalitis and pulmonary disease with substantial mortality. Initially considered geographically restricted to immune-competent, highly exposed individuals in the tropics, an apparent epidemic in North America has le...

journal_title：Future microbiology

authors： McMullan BJ,Sorrell TC,Chen SC

更新日期：2013-12-01 00:00:00

abstract：:Bacillus anthracis is a Gram-positive, spore-forming bacterium representing the etiological cause of anthrax, a rare lethal disease of animals and humans. Development of anthrax countermeasures has gained increasing attention owing to the potential use of B. anthracis spores as a bioterror weapon. The various forms of...

journal_title：Future microbiology

authors： Chitlaru T,Shafferman A

更新日期：2009-10-01 00:00:00

abstract：:Mark Wilcox speaks to Georgia Patey, Commissioning Editor: Professor Mark Wilcox is a Consultant Microbiologist and Head of Microbiology at the Leeds Teaching Hospitals (Leeds, UK), the Professor of Medical Microbiology at the University of Leeds (Leeds, UK), and is the Lead on Clostridium difficile and the Head of th...

journal_title：Future microbiology

authors： Wilcox M

更新日期：2016-08-01 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus) is a major global cause of human disease. Since the publication of the entire sequence of TIGR4 in 2001, our understanding of this human pathogen has increased significantly. Genetic studies, and the use of mutant strains have refined our understanding of the pathogenic mech...

journal_title：Future microbiology

authors： Preston JA,Dockrell DH

更新日期：2008-04-01 00:00:00

abstract：AIM:The aim was to evaluate the in vitro activity of fosfomycin against common uropathogens in a fosfomycin-naive population in India. METHODS:The authors prospectively collected and tested all consecutive isolates of Escherichia coli and Enterococcus spp. from urine samples between December 2009 and April 2010. RESU...

journal_title：Future microbiology

authors： Sahni RD,Balaji V,Varghese R,John J,Tansarli GS,Falagas ME

更新日期：2013-05-01 00:00:00

abstract：:Aim: To investigate the action mechanism of 1-benzyl-1,4-diazepane (1-BD) as efflux pump inhibitor (EPI) in Escherichia coli mutants: ΔacrAB or overexpressing AcrAB and AcrEF efflux pumps. Materials & methods: Effect of 1-BD on: antibiotic potentiation, by microdilution method; membrane functionality, by fluorimetric ...

journal_title：Future microbiology

authors： Casalone E,Vignolini T,Braconi L,Gardini L,Capitanio M,Pavone FS,Dei S,Teodori E

更新日期：2020-07-01 00:00:00

abstract：:Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...

journal_title：Future microbiology

authors： Zilberman-Itskovich S,Youngster I,Lazarovitch T,Bondarenco M,Toledano L,Kachlon Y,Mengesha B,Strul N,Zaidenstein R,Marchaim D

更新日期：2019-11-01 00:00:00

abstract：AIMS:Nosocomial infections cause significant morbidity and mortality in cancer patients. As a result of their debilitated immune system, cancer patients are likely candidates for colonization with anaerobes. We sought to compare the distribution of nosocomial infections in neutropenic and non-neutropenic cancer patient...

journal_title：Future microbiology

authors： El-Sharif A,Elkhatib WF,Ashour HM

更新日期：2012-12-01 00:00:00

abstract：AIM:Our aim is to investigate if the clusters of postsurgical mycobacterial infections, reported between 2004 and 2008 in seven geographically distant states in Brazil, were caused by a single mycobacterial strain. MATERIALS & METHODS:Available information from 929 surgical patients was obtained from local health auth...

journal_title：Future microbiology

authors： Leão SC,Viana-Niero C,Matsumoto CK,Lima KV,Lopes ML,Palaci M,Hadad DJ,Vinhas S,Duarte RS,Lourenço MC,Kipnis A,das Neves ZC,Gabardo BM,Ribeiro MO,Baethgen L,de Assis DB,Madalosso G,Chimara E,Dalcolmo MP

更新日期：2010-06-01 00:00:00

abstract：:The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...

journal_title：Future microbiology

authors： Rafei R,Osman M,Dabboussi F,Hamze M

更新日期：2019-08-01 00:00:00

abstract：:Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...

journal_title：Future microbiology

authors： Tovy A,Ankri S

更新日期：2010-12-01 00:00:00

abstract：:Influenza B viruses (IBVs) circulate annually along with influenza A (IAV) strains during seasonal epidemics. IBV can dominate influenza seasons and cause severe disease, particularly in children and adolescents. Research has revealed interesting aspects of IBV and highlighted the importance of these viruses in clinic...

journal_title：Future microbiology

authors： Koutsakos M,Nguyen TH,Barclay WS,Kedzierska K

更新日期：2016-01-01 00:00:00

abstract：:Micafungin is a new drug in the echinocandin class and is currently being investigated in Phase III clinical trials. Like other echinocandins, it inhibits 1,3-beta-D-glucan synthesis, thus achieving fungicidal activity against virtually all Candida spp., including those resistant to fluconazole, and fungistatic activi...

journal_title：Future microbiology

authors： Vehreschild JJ,Cornely OA

更新日期：2006-08-01 00:00:00

abstract：:Resistance continues to emerge as a leading cause for antiretroviral treatment failure. Several mutations in HIV reverse transcriptase (RT) confer resistance to non-nucleoside inhibitors (NNRTIs), vital components of antiretroviral combination therapies. Since the majority of mutations are located in the NNRTI binding...

journal_title：Future microbiology

authors： Frey KM

更新日期：2015-01-01 00:00:00

abstract：AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...

journal_title：Future microbiology

authors： Xu S,Yang J,Yin C,Zhao X

更新日期：2018-02-01 00:00:00

abstract：AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dom...

journal_title：Future microbiology

authors： Tan XL,Liu HY,Long J,Jiang Z,Luo Y,Zhao X,Cai S,Zhong X,Cen Z,Su J,Zhou H

更新日期：2019-03-01 00:00:00

abstract：AIM:To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. MATERIALS & METHODS:A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract i...

journal_title：Future microbiology

authors： Zhu T,Lu QB,Zhang SY,Wo Y,Zhuang L,Zhang PH,Zhang XA,Wei W,Liu W

更新日期：2017-05-01 00:00:00

abstract：:Aim: Bile salts promote the specific autolysis of pneumococcal cells, allowing the differentiation between Streptococcus pneumoniae and other viridans group streptococci (VGS). Material & methods: One hundred clinical VGS isolates identified by amplification and sequencing of 16S rRNA, groEL and sodA genes were analyz...

journal_title：Future microbiology

authors： Ercibengoa M,Morales M,Alonso M,Ardanuy C,Marimón JM

更新日期：2019-07-01 00:00:00

abstract：AIM:Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans. MATERIALS & METHODS:A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The functio...

journal_title：Future microbiology

authors： Zhang D,Dong Y,Yu Q,Kai Z,Zhang M,Jia C,Xiao C,Zhang B,Zhang B,Li M

更新日期：2017-11-01 00:00:00

abstract：:Among the 33 confirmed Bartonella species to date, more than half are hosted by rodent species, and at least five of them have been involved in human illness causing diverse symptoms including fever, myocarditis, endocarditis, lymphadenitis and hepatitis. In almost all countries, wild rodents are infected by extremely...

journal_title：Future microbiology

authors： Buffet JP,Kosoy M,Vayssier-Taussat M

更新日期：2013-09-01 00:00:00

abstract：:Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...

journal_title：Future microbiology

authors： Rolando M,Buchrieser C

更新日期：2012-03-01 00:00:00

abstract：:The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-depende...

journal_title：Future microbiology

authors： Correia I,Alonso-Monge R,Pla J

更新日期：2010-07-01 00:00:00

abstract：:Linda Hazlett is a department chair and distinguished professor at Wayne State University (MI, USA). Her research is focused on the host immune response to Pseudomonas aeruginosa and its role in ocular infections. Dr Hazlett has been funded continuously by the NIH by R01 support for 34 years. She is currently principa...

journal_title：Future microbiology

authors： Hazlett L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The seriousness to treat burn wounds infected with Pseudomonas aeruginosa led us to examine whether the effect of the carbapenem antibiotic imipenem is enhanced by hyperbaric oxygen (HBO). MATERIALS & METHODS:The effects of HBO (100% O2, 3 ATA, 5 h) in combination with imipenen on bacterial counts of six is...

journal_title：Future microbiology

authors： Lima FL,Joazeiro PP,Lancellotti M,de Hollanda LM,de Araújo Lima B,Linares E,Augusto O,Brocchi M,Giorgio S

更新日期：2015-01-01 00:00:00