Evaluation of fosfomycin activity against uropathogens in a fosfomycin-naive population in South India: a prospective study.


AIM:The aim was to evaluate the in vitro activity of fosfomycin against common uropathogens in a fosfomycin-naive population in India. METHODS:The authors prospectively collected and tested all consecutive isolates of Escherichia coli and Enterococcus spp. from urine samples between December 2009 and April 2010. RESULTS:A total of 3141 isolates were included in the study, 2416 E. coli and 725 Enterococcus spp. Fosfomycin was the most active antibiotic against both pathogens with an overall susceptibility of 83 and 99% for E. coli and Enterococcus spp, respectively. Among E. coli, 47.6% of the isolates were extended-spectrum β-lactamase producing, of which 81% were susceptible to fosfomycin, while 51.5% were multidrug resistant, with 75.7% of this portion being susceptible to fosfomycin. CONCLUSION:Fosfomycin exhibits good in vitro activity against both the uropathogens tested. Therefore, it might be considered as a treatment option for urinary tract infections in India; however, clinical trials should first reinforce the in vitro findings.


Future Microbiol


Future microbiology


Sahni RD,Balaji V,Varghese R,John J,Tansarli GS,Falagas ME




Has Abstract


2013-05-01 00:00:00












  • Know your enemy: managing resistant Gram-negative infections.

    abstract::Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, t...

    journal_title:Future microbiology



    authors: Eckmann C,Rojas LJ,Lyon S

    更新日期:2018-10-01 00:00:00

  • Controversies in the treatment of pneumococcal community-acquired pneumonia.

    abstract::Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Feldman C,Anderson R

    更新日期:2006-10-01 00:00:00

  • A novel triterpene from Astraeus hygrometricus induces reactive oxygen species leading to death in Leishmania donovani.

    abstract:AIM:The effect of astrakurkurone, a novel triterpene, isolated from Indian mushroom Astraeus hygrometricus has been investigated to elucidate the mechanisms involved in selective cell death of Leishmania donovani. MATERIALS & METHODS:The hypotheses were investigated using flow-cytometry, scanning electron microscopy a...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Mallick S,Dey S,Mandal S,Dutta A,Mukherjee D,Biswas G,Chatterjee S,Mallick S,Lai TK,Acharya K,Pal C

    更新日期:2015-01-01 00:00:00

  • Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.

    abstract:AIMS:To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS:The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were inte...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Chen ZF,Ai LY,Wang JL,Ren LL,Yu YN,Xu J,Chen HY,Yu J,Li M,Qin WX,Ma X,Shen N,Chen YX,Hong J,Fang JY

    更新日期:2015-01-01 00:00:00

  • The gut microbiome and the potentials of probiotics: an interview with Simon Gaisford.

    abstract::In this exclusive interview, Simon Gaisford discusses his current research into gut dysbiosis and its possible relevance to disease states, as well as the efficacy of probiotic supplementation and its possible use as treatment. This interview was conducted by Ellen Colvin, Commissioning Editor of Future Microbiology. ...

    journal_title:Future microbiology

    pub_type: 面试


    authors: Gaisford S

    更新日期:2019-03-01 00:00:00

  • Molecular phylogenetics and epidemiology of Candida albicans.

    abstract::Candida albicans, a diploid yeast commensal and opportunist pathogen, has evolved unusual mechanisms for maintenance of genetic diversity in the absence of a complete sexual cycle. These include chromosomal polymorphisms, mitotic recombination events, and gains and losses of heterozygosity, superimposed on a fundament...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Odds FC

    更新日期:2010-01-01 00:00:00

  • Epidemiology and virulence insights from MRSA and MSSA genome analysis.

    abstract::Staphylococcus aureus is a major human pathogen responsible for a wide diversity of infections ranging from localized to life threatening diseases. From 1961 and the emergence of methicillin-resistant S. aureus (MRSA), this bacterium has shown a particular capacity to survive and adapt to drastic environmental changes...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Lazarevic V,Beaume M,Corvaglia A,Hernandez D,Schrenzel J,François P

    更新日期:2011-05-01 00:00:00

  • Direct and indirect effects of the 13-valent pneumococcal conjugate vaccine administered to infants and young children.

    abstract::This paper analyzes the most recent reports regarding the direct and indirect effects of the 13-valent pneumococcal conjugate vaccine (PCV13) when administered to infants and young children. PCV13 extends the protective effects reported for the 7-valent pneumococcal conjugate vaccine (PCV7). A further reduction in the...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Esposito S,Principi N,ESCMID Vaccine Study Group.

    更新日期:2015-01-01 00:00:00

  • The role of bacteriophages in periodontal health and disease.

    abstract::The human periodontium health is commonly compromised by chronic inflammatory conditions and has become a major public health concern. Dental plaque, the precursor of periodontal disease, is a complex biofilm consisting mainly of bacteria, but also archaea, protozoa, fungi and viruses. Viruses that specifically infect...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pinto G,Silva MD,Peddey M,Sillankorva S,Azeredo J

    更新日期:2016-10-01 00:00:00

  • Tuberculosis drugs: new candidates and how to find more.

    abstract::The recent years have witnessed significant progress in the development of new drug candidates for the treatment of TB. While many of these are now in clinical trials, continued research is needed in order to sustain the drug discovery pipeline and meet the increasing needs of TB patients. These include shortening tre...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Sala C,Hartkoorn RC

    更新日期:2011-06-01 00:00:00

  • Myxopyronin: a punch in the jaws of bacterial RNA polymerase.

    abstract::Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tupin A,Gualtieri M,Brodolin K,Leonetti JP

    更新日期:2009-03-01 00:00:00

  • Delafloxacin: an improved fluoroquinolone developed through advanced molecular engineering.

    abstract::The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challeng...

    journal_title:Future microbiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bassetti M,Righi E,Pecori D,Tillotson G

    更新日期:2018-08-01 00:00:00

  • Alterations of zinc homeostasis in response to Cryptococcus neoformans in a murine macrophage cell line.

    abstract:AIM:To evaluate alterations of zinc homeostasis in macrophages exposed to Cryptococcus neoformans. Materials & methods: Using a fluorescent zinc probe-based flow cytometry and atomic absorption spectrometry, zinc levels were evaluated in J774.A1 cell lines exposed to C. neoformans H99 cells. The transcription profile o...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Dos Santos FM,Piffer AC,Schneider RO,Ribeiro NS,Garcia AWA,Schrank A,Kmetzsch L,Vainstein MH,Staats CC

    更新日期:2017-05-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • Technologies for the development of West Nile virus vaccines.

    abstract::West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Ulbert S,Magnusson SE

    更新日期:2014-01-01 00:00:00

  • Protective host immune responses to Salmonella infection.

    abstract::Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pham OH,McSorley SJ

    更新日期:2015-01-01 00:00:00

  • Antibiotic-associated diarrhea: epidemiology, trends and treatment.

    abstract::A common complication of antibiotic use is the development of gastrointestinal disease. This complication ranges from mild diarrhea to pseudomembranous colitis. Outbreaks of antibiotic-associated diarrhea (AAD) may also occur in healthcare settings, usually caused by Clostridium difficile. AAD typically occurs in 5-35...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: McFarland LV

    更新日期:2008-10-01 00:00:00

  • Letermovir for prophylaxis of cytomegalovirus manifestations in adult allogeneic hematopoietic stem cell transplant recipients.

    abstract::Cytomegalovirus (CMV) manifestations remain important complications after allogeneic hematopoietic stem cell transplantation (HSCT), even in the current era. Unfortunately, available anti-CMV agents, mainly viral polymerase inhibitors, have a substantial risk of myelosuppression and nephrotoxicity. Letermovir, a novel...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Hecke SV,Calcoen B,Lagrou K,Maertens J

    更新日期:2019-02-01 00:00:00

  • Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.

    abstract::Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped into two distinct therapeutic groups, namely the nucleoside and nucleotide RT inhibitors (NRTIs), and the non-nucleoside RT inhibitors (NNRTI...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Sluis-Cremer N,Wainberg MA,Schinazi RF

    更新日期:2015-01-01 00:00:00

  • MAPK cell-cycle regulation in Saccharomyces cerevisiae and Candida albicans.

    abstract::The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-depende...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Correia I,Alonso-Monge R,Pla J

    更新日期:2010-07-01 00:00:00

  • Histoplasma capsulatum, lung infection and immunity.

    abstract::Histoplasma capsulatum, an environmental fungus, is the most common endemic pulmonary mycosis in the USA. Disease is most frequently observed in immunocompromised patients living in endemic areas. We present the mechanisms of fungal recognition, innate immune response and adaptive immune response that lead to protecti...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Horwath MC,Fecher RA,Deepe GS Jr

    更新日期:2015-01-01 00:00:00

  • Leprosy as a model of immunity.

    abstract:: Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well as its degraded comp...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Degang Y,Nakamura K,Akama T,Ishido Y,Luo Y,Ishii N,Suzuki K

    更新日期:2014-01-01 00:00:00

  • Current status and future perspectives on molecular and serological methods in diagnostic mycology.

    abstract::Invasive fungal infections are an important cause of infectious morbidity. Nonculture-based methods are increasingly used for rapid, accurate diagnosis to improve patient outcomes. New and existing DNA amplification platforms have high sensitivity and specificity for direct detection and identification of fungi in cli...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Lau A,Chen S,Sleiman S,Sorrell T

    更新日期:2009-11-01 00:00:00

  • Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence.

    abstract::Living organisms adapt to the dynamic external environment for their survival. Environmental adaptation in prokaryotes is thought to be primarily accomplished by signaling events mediated by two-component systems, consisting of histidine kinases and response regulators. However, eukaryotic-like serine/threonine kinase...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Burnside K,Rajagopal L

    更新日期:2011-07-01 00:00:00

  • Antibodies as a source of anti-infective peptides: an update.

    abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

    更新日期:2015-01-01 00:00:00

  • Global approaches to study protein-protein interactions among viruses and hosts.

    abstract::While high-throughput protein-protein interaction screens were first published approximately 10 years ago, systematic attempts to map interactions among viruses and hosts started only a few years ago. HIV-human interactions dominate host-pathogen interaction databases (with approximately 2000 interactions) despite the...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Mendez-Rios J,Uetz P

    更新日期:2010-02-01 00:00:00

  • In vitro susceptibility testing in Aspergillus species: an update.

    abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Lass-Flörl C

    更新日期:2010-05-01 00:00:00

  • Treatment of hepatitis B virus: an update.

    abstract::Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Ward H,Tang L,Poonia B,Kottilil S

    更新日期:2016-12-01 00:00:00

  • Potential for adaptation overrides cost of resistance.

    abstract:AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolution...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Moura de Sousa J,Sousa A,Bourgard C,Gordo I

    更新日期:2015-01-01 00:00:00

  • New perspectives in the management of Pseudomonas aeruginosa infections.

    abstract::Infections with Pseudomonas aeruginosa are a major health problem, especially for immune-compromised and cystic fibrosis patients, owing to the particular drug resistance of the microorganism. The aim of this review is to provide recent insights into strategies under investigation for prevention and therapy of these i...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Savoia D

    更新日期:2014-01-01 00:00:00