Genetics of Coxiella burnetii: on the path of specialization.

Abstract:

:Coxiella burnetii is an extremely infectious, zoonotic agent that causes Q fever in humans. With the exception of New Zealand, the bacterium is distributed worldwide. Coxiella is classified as a select agent based on its past and potential use as a bioweapon and its threat to public health. Despite decades of research, we know relatively little regarding Coxiella?s molecular pathogenesis, and a vaccine is not widely available. This article briefly reviews the unusual genetics of C. burnetii; a pathogen that retains telltale genetic mementos collected over the course of its evolutionary path from a free-living bacterium to an obligate intracellular parasite of eukaryotic host cell phagosomes. Understanding why these genetic elements are maintained may help us better understand the biology of this fascinating pathogen.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Minnick MF,Raghavan R

doi

10.2217/fmb.11.116

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1297-314

issue

11

eissn

1746-0913

issn

1746-0921

journal_volume

6

pub_type

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