Abstract:
AIMS:This study aimed to evaluate the antimicrobial activity of two different formulations of bioglass BAG-S53P4 against multiresistant microorganisms involved in bone infections, and the capability of bioglass to select for resistance. METHODS:Antibacterial activity was evaluated by means of killing curves. The ability to select for resistant bacteria was evaluated by subculturing microorganisms in serial dilutions of bioglass. Scanning electron microscope acquisitions were conducted to evaluate bioglass-induced morphology changes. RESULTS:BAG-S53P4 formulations display a high antimicrobial activity and do not seem to select for resistance. Scanning electron microscopy analysis showed cell shrinkage and membrane damage after exposure to bioglass. CONCLUSIONS:BAG-S53P4 has a significant potential as bone substitute for the treatment of infections caused by multiresistant microorganisms.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Drago L,De Vecchi E,Bortolin M,Toscano M,Mattina R,Romanò CLdoi
10.2217/FMB.15.57subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1293-9issue
8eissn
1746-0913issn
1746-0921journal_volume
10pub_type
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journal_title:Future microbiology
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更新日期:2010-07-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2010-11-01 00:00:00
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更新日期:2014-01-01 00:00:00
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