Oritavancin: a potential weapon in the battle against serious Gram-positive pathogens.

Abstract:

:Oritavancin is a lipoglycopeptide antibiotic with activity against aerobic and anaerobic Gram-positive bacteria. Oritavancin separates itself from other glycopeptides through its potent in vitro activity against resistant isolates of Staphylococcus aureus, Enterococcus spp. and Streptococcus spp. Oritavancin possesses a long half-life that should allow, at maximum, once-daily dosing. Currently, oritavancin has completed two Phase III trials and one Phase II trial for the treatment of complicated skin and skin structure infections, and two Phase II trials for the treatment of Gram-positive bacteremia. In all instances, oritavancin displayed favorable outcomes and was noninferior to comparator agents (vancomycin followed by oral cephalexin) when a comparison was made. Further studies are necessary to fully characterize dose and clinical role.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Crandon J,Nicolau DP

doi

10.2217/17460913.3.3.251

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

251-63

issue

3

eissn

1746-0913

issn

1746-0921

journal_volume

3

pub_type

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