Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome.


:Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might lead to novel therapeutics for tuberculosis. Recent reports provided evidence that M. tuberculosis relies on amino acid uptake and degradation pathways to thrive inside its host. This opens novel research venues for the development of innovative antimicrobials against TB.


Future Microbiol


Future microbiology


Gouzy A,Poquet Y,Neyrolles O




Has Abstract


2014-01-01 00:00:00












  • Alterations of zinc homeostasis in response to Cryptococcus neoformans in a murine macrophage cell line.

    abstract:AIM:To evaluate alterations of zinc homeostasis in macrophages exposed to Cryptococcus neoformans. Materials & methods: Using a fluorescent zinc probe-based flow cytometry and atomic absorption spectrometry, zinc levels were evaluated in J774.A1 cell lines exposed to C. neoformans H99 cells. The transcription profile o...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Dos Santos FM,Piffer AC,Schneider RO,Ribeiro NS,Garcia AWA,Schrank A,Kmetzsch L,Vainstein MH,Staats CC

    更新日期:2017-05-01 00:00:00

  • Clinical metagenomics for the management of hospital- and healthcare-acquired pneumonia.

    abstract::The increasing burden of multidrug-resistant bacteria affects the management of several infections. In order to prescribe adequate antibiotics, clinicians facing severe infections such as hospital-acquired pneumonia (HAP) need to promptly identify the pathogens and know their antibiotic susceptibility profiles (AST), ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ruppé E,Baud D,Schicklin S,Guigon G,Schrenzel J

    更新日期:2016-01-01 00:00:00

  • Evaluation of the antifungal activity in vitro of midazolam against fluconazole-resistant Candida spp. isolates.

    abstract::Aim: The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical Candida spp. in planktonic and biofilm form. Materials & methods: The antifungal activity was observed using the broth microdilution technique. Flow cytometry tests we...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Holanda MA,da Silva CR,de A Neto JB,do Av Sá LG,do Nascimento FB,Barroso DD,da Silva LJ,Cândido TM,Leitão AC,Barbosa AD,de Moraes MO,Cc B,Júnior HVN

    更新日期:2021-01-01 00:00:00

  • A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance.

    abstract::The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A m...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Cohen A,Bont L,Engelhard D,Moore E,Fernández D,Kreisberg-Greenblatt R,Oved K,Eden E,Hays JP

    更新日期:2015-01-01 00:00:00

  • Promises and failures of gallium as an antibacterial agent.

    abstract::Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Minandri F,Bonchi C,Frangipani E,Imperi F,Visca P

    更新日期:2014-01-01 00:00:00

  • Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department.

    abstract::Aim: In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. Materials & methods: If subjects presented with febrile symptoms at the ED, 13 biomarkers' levels, including CD64 on neutrophils (n...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Bourgoin P,Lediagon G,Arnoux I,Bernot D,Morange PE,Michelet P,Malergue F,Markarian T

    更新日期:2020-02-01 00:00:00

  • The impact of intestinal microbiota on weight loss in Parkinson's disease patients: a pilot study.

    abstract::Background: There is increasing evidence of the association between microbiome dysfunction and Parkinson's disease (PD). Moreover, some PD patients suffer from unintentional weight loss (WL) which may precede the motor manifestations of the disease. Materials & methods: Gut microbiota profiling by 16S rRNA gene sequen...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Del Chierico F,Grassini P,Quagliariello A,Torti M,Russo A,Reddel S,Stocchi F

    更新日期:2020-09-01 00:00:00

  • Pseudomonas aeruginosa: my research passion. Interview by Hannah Branch.

    abstract::Linda Hazlett is a department chair and distinguished professor at Wayne State University (MI, USA). Her research is focused on the host immune response to Pseudomonas aeruginosa and its role in ocular infections. Dr Hazlett has been funded continuously by the NIH by R01 support for 34 years. She is currently principa...

    journal_title:Future microbiology

    pub_type: 面试


    authors: Hazlett L

    更新日期:2013-07-01 00:00:00

  • Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria.

    abstract::Biocides, primarily those containing quaternary ammonium compounds (QAC), are heavily used in hospital environments and various industries (e.g., food, water, cosmetic). To date, little attention has been paid to potential implications of QAC use in the emergence of antibiotic resistance, especially fluoroquinolone-re...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Buffet-Bataillon S,Tattevin P,Maillard JY,Bonnaure-Mallet M,Jolivet-Gougeon A

    更新日期:2016-01-01 00:00:00

  • Global approaches to study protein-protein interactions among viruses and hosts.

    abstract::While high-throughput protein-protein interaction screens were first published approximately 10 years ago, systematic attempts to map interactions among viruses and hosts started only a few years ago. HIV-human interactions dominate host-pathogen interaction databases (with approximately 2000 interactions) despite the...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Mendez-Rios J,Uetz P

    更新日期:2010-02-01 00:00:00

  • Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids.

    abstract:AIM:To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. METHODS & RESULTS:Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm forma...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Bhargava N,Singh SP,Sharma A,Sharma P,Capalash N

    更新日期:2015-01-01 00:00:00

  • The role of bacteriophages in periodontal health and disease.

    abstract::The human periodontium health is commonly compromised by chronic inflammatory conditions and has become a major public health concern. Dental plaque, the precursor of periodontal disease, is a complex biofilm consisting mainly of bacteria, but also archaea, protozoa, fungi and viruses. Viruses that specifically infect...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pinto G,Silva MD,Peddey M,Sillankorva S,Azeredo J

    更新日期:2016-10-01 00:00:00

  • Epidemic of surgical-site infections by a single clone of rapidly growing mycobacteria in Brazil.

    abstract:AIM:Our aim is to investigate if the clusters of postsurgical mycobacterial infections, reported between 2004 and 2008 in seven geographically distant states in Brazil, were caused by a single mycobacterial strain. MATERIALS & METHODS:Available information from 929 surgical patients was obtained from local health auth...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Leão SC,Viana-Niero C,Matsumoto CK,Lima KV,Lopes ML,Palaci M,Hadad DJ,Vinhas S,Duarte RS,Lourenço MC,Kipnis A,das Neves ZC,Gabardo BM,Ribeiro MO,Baethgen L,de Assis DB,Madalosso G,Chimara E,Dalcolmo MP

    更新日期:2010-06-01 00:00:00

  • Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?

    abstract::Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Al-Dujaili LJ,Clerkin PP,Clement C,McFerrin HE,Bhattacharjee PS,Varnell ED,Kaufman HE,Hill JM

    更新日期:2011-08-01 00:00:00

  • The differential effect of clarithromycin and azithromycin on induction of macrolide resistance in Mycobacterium abscessus.

    abstract::Aim: Antibiotic resistance in Mycobacterium abscessus renders treatment poorly effective. Despite erm(41)-gene-mediated macrolide resistance, treatment with azithromycin or clarithromycin is recommended. It is contested whether macrolides differ in erm(41) induction. We determine whether this is the case. Methods:M. a...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Schildkraut JA,Pennings LJ,Ruth MM,de Brouwer AP,Wertheim HF,Hoefsloot W,de Jong A,van Ingen J

    更新日期:2019-06-01 00:00:00

  • Antibodies as a source of anti-infective peptides: an update.

    abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

    更新日期:2015-01-01 00:00:00

  • Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections.

    abstract::Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review desc...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Mancini N,Marrone L,Clementi N,Sautto GA,Clementi M,Burioni R

    更新日期:2015-01-01 00:00:00

  • Cryptococcus gattii infections: contemporary aspects of epidemiology, clinical manifestations and management of infection.

    abstract::Cryptococcus gattii is an important primary and opportunistic pathogen, predominantly causing meningoencephalitis and pulmonary disease with substantial mortality. Initially considered geographically restricted to immune-competent, highly exposed individuals in the tropics, an apparent epidemic in North America has le...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: McMullan BJ,Sorrell TC,Chen SC

    更新日期:2013-12-01 00:00:00

  • Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis.

    abstract:AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) rende...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Correia I,Román E,Prieto D,Eisman B,Pla J

    更新日期:2016-01-01 00:00:00

  • Immunotherapeutic potential of neutralizing antibodies targeting conserved regions of the HCV envelope glycoprotein E2.

    abstract::HCV is a major cause of chronic liver disease worldwide. There is no vaccine available and the current antiviral therapies fail to cure approximately half of treated patients. Liver disease caused by HCV infection is the most common indication for orthotopic liver transplantation. Unfortunately, reinfection of the new...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Angus AG,Patel AH

    更新日期:2011-03-01 00:00:00

  • Use of high-throughput mass spectrometry to elucidate host-pathogen interactions in Salmonella.

    abstract::Capabilities in mass spectrometry are evolving rapidly, with recent improvements in sensitivity, data analysis and, most important from the standpoint of this review, much higher throughput, allowing analysis of many samples in a single day. This short review describes how these improvements in mass spectrometry can b...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rodland KD,Adkins JN,Ansong C,Chowdhury S,Manes NP,Shi L,Yoon H,Smith RD,Heffron F

    更新日期:2008-12-01 00:00:00

  • Report from the 4th Advances Against Aspergillosis Conference.

    abstract::Traditionally, the patients believed to be at highest risk of invasive aspergillosis (IA) are those who are neutropenic due to chemotherapy for hematological malignancy or those undergoing allogeneic hematopoietic stem cell transplantation. However, emerging data show that other patients are vulnerable to IA, even tho...

    journal_title:Future microbiology



    authors: Sheppard D,Grist LM

    更新日期:2010-07-01 00:00:00

  • Inhibition of growth and gene expression in Staphylococcus aureus by anti-gyrA peptide nucleic acid.

    abstract::Aim: Multidrug-resistant Staphylococcus aureus isolates have become a serious concern in clinical microbiology. Antisense strategy, which specifically targets essential genes, could be helpful. Materials & methods:S. aureus cultures were treated with peptide conjugate-peptide nucleic acid (PPNA) specific for the gyrA ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tavakoli M,Hashemi A,Vaezjalali M,Mohammadzadeh M,Goudarzi H

    更新日期:2019-09-01 00:00:00

  • Update on the epidemiological typing methods for Acinetobacter baumannii.

    abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rafei R,Osman M,Dabboussi F,Hamze M

    更新日期:2019-08-01 00:00:00

  • Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.

    abstract:AIMS:To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS:The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were inte...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Chen ZF,Ai LY,Wang JL,Ren LL,Yu YN,Xu J,Chen HY,Yu J,Li M,Qin WX,Ma X,Shen N,Chen YX,Hong J,Fang JY

    更新日期:2015-01-01 00:00:00

  • Use of the plaque assay for testing the antibiotic susceptibility of intracellular bacteria.

    abstract::The plaque assay was first described for titration of bacterial inoculums and clonal isolation, and was later adapted for testing antibiotics susceptibility and to study virulence factors and motility of bacteria. Over time, the sensitivity and reproducibility of the technique has been improved. Usually, the number of...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Edouard S,Raoult D

    更新日期:2013-10-01 00:00:00

  • Managing invasive fungal disease in immunocompromised patients.

    abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...

    journal_title:Future microbiology



    authors: Maertens J,Bryan J

    更新日期:2010-12-01 00:00:00

  • Virulence factors in pneumococcal respiratory pathogenesis.

    abstract::Streptococcus pneumoniae (the pneumococcus) is a major global cause of human disease. Since the publication of the entire sequence of TIGR4 in 2001, our understanding of this human pathogen has increased significantly. Genetic studies, and the use of mutant strains have refined our understanding of the pathogenic mech...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Preston JA,Dockrell DH

    更新日期:2008-04-01 00:00:00

  • Tregs in the immune response of BALB/c mice experimentally infected with species of the Sporothrix genus.

    abstract::Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We us...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Corrêa-Moreira D,De Luca PM,Romeo O,C Menezes R,Paes RA,Oliveira RZ,de Moraes AM,de L Neto RG,Moraes Borba C,E de Oliveira MM

    更新日期:2020-09-01 00:00:00

  • Genetic and population analyses of Vibrio parahaemolyticus isolates from three major coastal regions in China.

    abstract:AIM:This study aims to evaluate the genetic and population structure of Vibrio parahaemolyticus in the major coastal regions of China. MATERIALS & METHODS:Multilocus sequence typing was performed. RESULTS:Insertion of large sequence into recA happened in nearly 30 strains, which were untypeable by multilocus sequence...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li P,Xin W,Kang L,Chen Z,Guo C,Gao S,Yang H,Ji B,Yan Y,Wang H,Zhou D,Yang W,Wang J

    更新日期:2018-09-01 00:00:00