Abstract:
AIM:To evaluate alterations of zinc homeostasis in macrophages exposed to Cryptococcus neoformans. Materials & methods: Using a fluorescent zinc probe-based flow cytometry and atomic absorption spectrometry, zinc levels were evaluated in J774.A1 cell lines exposed to C. neoformans H99 cells. The transcription profile of macrophage zinc related homeostasis genes - metallothioneins and zinc transporters (ZnTs) of the SLC30 and SLC39 (Zrt-Irt-protein) families - was analyzed by quantitative PCR. RESULTS:Macrophage intracellular labile zinc levels decreased following exposure to C. neoformans. A significant decrease in transcription levels was detected in specific ZnTs from both the Zrt-Irt-protein and ZnT families, especially 24 h after infection. CONCLUSION:These findings suggest that macrophages may exhibit zinc depletion in response to C. neoformans infection.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Dos Santos FM,Piffer AC,Schneider RO,Ribeiro NS,Garcia AWA,Schrank A,Kmetzsch L,Vainstein MH,Staats CCdoi
10.2217/fmb-2016-0160subject
Has Abstractpub_date
2017-05-01 00:00:00pages
491-504eissn
1746-0913issn
1746-0921journal_volume
12pub_type
杂志文章abstract::Invasive fungal infections are an important cause of infectious morbidity. Nonculture-based methods are increasingly used for rapid, accurate diagnosis to improve patient outcomes. New and existing DNA amplification platforms have high sensitivity and specificity for direct detection and identification of fungi in cli...
journal_title:Future microbiology
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