Abstract:
:Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires prompt management. Despite effective antibiotic and adjunctive therapies, mortality is still unacceptably high in acute bacterial meningitis in children as this mortality did not substantially improve since the first use of antimicrobial therapies in the mid-20th century. β-lactams and particularly third-generation cephalosporins (ceftriaxone or cefotaxime) penetrate most body tissues and fluids, such as the cerebrospinal fluid, well. They are effective against the three most frequent bacterial causative agents of acute bacterial meningitis (Neisseria meningitidis, Streptococcus pneumoniae and Hemophilus influenzae). They are currently the consensual choices for the presumptive treatment of acute bacterial meningitis and usually used as a bolus every 4-6 h. Pelkonen et al. published a prospective, double-blind, single-center study with a two-by-two factorial design that aimed to explore the benefits in children of infused compared with bolus cefotaxime administration. Each group (bolus and infusion) was divided into two subgroups (with oral paracetamol or with placebo). No significant difference was observed for the final outcomes (mortality or severe neurological sequela and deafness) in the four subgroups. However, a post-hoc analysis of the results suggested that cefotaxime infusion plus paracetamol recipients had significant lower mortality during the first 72 h, irrespective of causative agents. However, the relevance of this study in sub-Saharan Africa is still difficult to evaluate as more than half of the initially assessed patients did not meet the inclusion criteria. The extension of the conclusions to developed countries may require further evaluations in terms of pharmacokinetic/pharmacodynamic properties as well as a thorough characterization of the causative agents under the view of the heterogeneous genetic structure of circulating bacterial strains in developed countries.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Taha MK,Deghmane AEdoi
10.2217/fmb.11.103subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1125-9issue
10eissn
1746-0913issn
1746-0921journal_volume
6pub_type
评论,杂志文章abstract::Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped into two distinct therapeutic groups, namely the nucleoside and nucleotide RT inhibitors (NRTIs), and the non-nucleoside RT inhibitors (NNRTI...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.106
更新日期:2015-01-01 00:00:00
abstract::Aim: The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical Candida spp. in planktonic and biofilm form. Materials & methods: The antifungal activity was observed using the broth microdilution technique. Flow cytometry tests we...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0080
更新日期:2021-01-01 00:00:00
abstract:AIM:The effect of astrakurkurone, a novel triterpene, isolated from Indian mushroom Astraeus hygrometricus has been investigated to elucidate the mechanisms involved in selective cell death of Leishmania donovani. MATERIALS & METHODS:The hypotheses were investigated using flow-cytometry, scanning electron microscopy a...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.14.149
更新日期:2015-01-01 00:00:00
abstract::Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0167
更新日期:2019-09-01 00:00:00
abstract::The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challeng...
journal_title:Future microbiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2217/fmb-2018-0067
更新日期:2018-08-01 00:00:00
abstract::Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2016-0128
更新日期:2016-12-01 00:00:00
abstract::Aim: Cryptococcosis causes significant morbidity and mortality worldwide, but pediatric data are limited. Methods: A retrospective literature review of Australian pediatric cryptococcosis and additional 10-year audit of cases from a large pediatric network. Results: 22 cases of cryptococcosis in children were identifi...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2019-0215
更新日期:2019-12-01 00:00:00
abstract:AIM:Our aim is to investigate if the clusters of postsurgical mycobacterial infections, reported between 2004 and 2008 in seven geographically distant states in Brazil, were caused by a single mycobacterial strain. MATERIALS & METHODS:Available information from 929 surgical patients was obtained from local health auth...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.10.49
更新日期:2010-06-01 00:00:00
abstract:: Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well as its degraded comp...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.13.140
更新日期:2014-01-01 00:00:00
abstract:AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) rende...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.127
更新日期:2016-01-01 00:00:00
abstract::Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We us...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2020-0046
更新日期:2020-09-01 00:00:00
abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.15
更新日期:2010-03-01 00:00:00
abstract::Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2017-0058
更新日期:2017-09-01 00:00:00
abstract::Organism-wide approaches examining the genetic mechanisms controlling growth and proliferation have proven to be a powerful tool in the study of pathogenic fungi. For many fungal pathogens techniques to study transcription and protein expression are particularly useful, and offer insights into infection processes by t...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.16.9
更新日期:2016-01-01 00:00:00
abstract::Aim: Antibiotic resistance in Mycobacterium abscessus renders treatment poorly effective. Despite erm(41)-gene-mediated macrolide resistance, treatment with azithromycin or clarithromycin is recommended. It is contested whether macrolides differ in erm(41) induction. We determine whether this is the case. Methods:M. a...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0310
更新日期:2019-06-01 00:00:00
abstract::A number of viruses in the family Arenaviridae cause severe illness in humans. Lassa virus in West Africa and a number of agents in South America produce hemorrhagic fever in persons exposed to aerosolized excretions of the pathogens' rodent hosts. Because arenaviruses are not transmitted by arthropods, and person-to-...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.11.132
更新日期:2011-12-01 00:00:00
abstract:AIM:A DNA microarray-based assay for the detection of antimicrobial resistance (AMR) genes was used to study carbapenemase-producing organisms at the Kidney Center of Rawalpindi, Pakistan. METHODS:The evaluation of this assay was performed using 97 reference strains with confirmed AMR genes. Testing of 7857 clinical s...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0082
更新日期:2018-09-01 00:00:00
abstract::Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.140
更新日期:2010-12-01 00:00:00
abstract:AIM:The purpose of current study is to find out relationship between cas9 gene and antimicrobial resistance in Campylobacter jejuni NCTC11168. MATERIALS & METHODS:The involvement of the cas9 gene in antimicrobial resistance of C. jejuni was determined by assessment of minimum inhibitory concentration, clustered regula...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0234
更新日期:2018-12-01 00:00:00
abstract::Some intracellular/membranous factors exert intrinsic immunity against viral pathogens. Most recently, SAMHD1 has been shown to be one of these factors. SAMHD1 is a nucleus-localized protein, and mutations in the gene are associated with Aicardi-Goutières syndrome. As a triphosphohydrolase, it depletes the intracellul...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.12.81
更新日期:2012-09-01 00:00:00
abstract::Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.43
更新日期:2013-06-01 00:00:00
abstract::Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogen...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0266
更新日期:2020-06-01 00:00:00
abstract::Surgical procedures for the symptomatic removal of the gallbladder and the vermiform appendix have been posited to adversely shift the assemblage of the intestinal microbiome increasing the risk of disease. The associated mechanisms have been linked with dysbiosis of the gut microbiota. Cholecystectomy causes changes ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0325
更新日期:2020-05-01 00:00:00
abstract:AIM:To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. METHODS:95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. RESULTS:The isolates showed a high diversity (IOD 0.964) w...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0013
更新日期:2016-07-01 00:00:00
abstract:AIMS:AFN-1252 is a novel inhibitor of FabI, an essential enzyme in Staphylococcus spp. This study was undertaken to assess the safety, tolerability and pharmacokinetic properties of AFN-1252, following oral administration in an ascending dose trial. MATERIALS & METHODS:This was a double-blind, randomized, placebo-cont...
journal_title:Future microbiology
pub_type: 杂志文章,随机对照试验
doi:10.2217/fmb.15.101
更新日期:2015-01-01 00:00:00
abstract:AIMS:To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS:The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were inte...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.66
更新日期:2015-01-01 00:00:00
abstract::A multidisplay vaccine delivery system has been developed that is nonreplicating and has a protein-based particulate structure. The structure is composed of helical tubules comprising multiple copies of a single nonstructural (NS) protein 1 of bluetongue virus. The helical assemblies present the C terminus of the prot...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.3.3.351
更新日期:2008-06-01 00:00:00
abstract::Bacillus anthracis is a Gram-positive, spore-forming bacterium representing the etiological cause of anthrax, a rare lethal disease of animals and humans. Development of anthrax countermeasures has gained increasing attention owing to the potential use of B. anthracis spores as a bioterror weapon. The various forms of...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.09.73
更新日期:2009-10-01 00:00:00
abstract::Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest preva...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2016-0200
更新日期:2017-07-01 00:00:00
abstract::Cryptococcus gattii is an important primary and opportunistic pathogen, predominantly causing meningoencephalitis and pulmonary disease with substantial mortality. Initially considered geographically restricted to immune-competent, highly exposed individuals in the tropics, an apparent epidemic in North America has le...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.123
更新日期:2013-12-01 00:00:00