Immediate outcomes of bacterial meningitis in childhood may benefit from slow initial β-lactam infusion and oral paracetamol.


:Evaluation of: Pelkonen T, Roine I, Cruzeiro ML, Pitkaranta A, Kataja M, Peltola H. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect. Dis. 11(8), 613-621 (2011). Acute bacterial meningitis is a medical emergency that requires prompt management. Despite effective antibiotic and adjunctive therapies, mortality is still unacceptably high in acute bacterial meningitis in children as this mortality did not substantially improve since the first use of antimicrobial therapies in the mid-20th century. β-lactams and particularly third-generation cephalosporins (ceftriaxone or cefotaxime) penetrate most body tissues and fluids, such as the cerebrospinal fluid, well. They are effective against the three most frequent bacterial causative agents of acute bacterial meningitis (Neisseria meningitidis, Streptococcus pneumoniae and Hemophilus influenzae). They are currently the consensual choices for the presumptive treatment of acute bacterial meningitis and usually used as a bolus every 4-6 h. Pelkonen et al. published a prospective, double-blind, single-center study with a two-by-two factorial design that aimed to explore the benefits in children of infused compared with bolus cefotaxime administration. Each group (bolus and infusion) was divided into two subgroups (with oral paracetamol or with placebo). No significant difference was observed for the final outcomes (mortality or severe neurological sequela and deafness) in the four subgroups. However, a post-hoc analysis of the results suggested that cefotaxime infusion plus paracetamol recipients had significant lower mortality during the first 72 h, irrespective of causative agents. However, the relevance of this study in sub-Saharan Africa is still difficult to evaluate as more than half of the initially assessed patients did not meet the inclusion criteria. The extension of the conclusions to developed countries may require further evaluations in terms of pharmacokinetic/pharmacodynamic properties as well as a thorough characterization of the causative agents under the view of the heterogeneous genetic structure of circulating bacterial strains in developed countries.


Future Microbiol


Future microbiology


Taha MK,Deghmane AE




Has Abstract


2011-10-01 00:00:00












  • Evaluation of different microtiter plate-based methods for the quantitative assessment of Staphylococcus aureus biofilms.

    abstract:AIM:To quantitatively assess Staphylococcus aureus biofilms. MATERIALS & METHODS:In addition to the qualitative Congo red agar (CRA) method, we used the bioluminescence (BLM), safranine (SAF), crystal violet (CRV) and resazurin (RES) high-throughput microtiter plate-based quantitative assays. RESULTS:60.47% (26/43) o...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Elkhatib WF,Khairalla AS,Ashour HM

    更新日期:2014-01-01 00:00:00

  • Prediction of micafungin area under the curve data by using peak concentration: applicability and utility in antifungal therapy.

    abstract:AIM:To describe a predictive model to obtain the area under the plasma concentration versus time curve (AUC) for micafungin to aid in dosing strategies in pediatric patients. METHODS:Using published pharmacokinetic data a linear regression model to describe the Cmax versus AUCtau was developed. The mean absolute error...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Srinivas NR

    更新日期:2016-01-01 00:00:00

  • Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital.

    abstract::Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. Methods: Twenty-eight nonduplicate CRAB isolates detected a...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Osman M,B Halimeh F,Rafei R,Mallat H,Tom JE,Raad EB,M Diene S,Jamal S,Atrouni AA,Dabboussi F,Moudani W,Madec JY,Saras E,Lupo A,Haenni M,Rolain JM,Hamze M

    更新日期:2020-10-01 00:00:00

  • Molecular phylogenetics and epidemiology of Candida albicans.

    abstract::Candida albicans, a diploid yeast commensal and opportunist pathogen, has evolved unusual mechanisms for maintenance of genetic diversity in the absence of a complete sexual cycle. These include chromosomal polymorphisms, mitotic recombination events, and gains and losses of heterozygosity, superimposed on a fundament...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Odds FC

    更新日期:2010-01-01 00:00:00

  • Manipulation of the bluetongue virus tubules for immunogen delivery.

    abstract::A multidisplay vaccine delivery system has been developed that is nonreplicating and has a protein-based particulate structure. The structure is composed of helical tubules comprising multiple copies of a single nonstructural (NS) protein 1 of bluetongue virus. The helical assemblies present the C terminus of the prot...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Murphy A,Roy P

    更新日期:2008-06-01 00:00:00

  • Managing invasive fungal disease in immunocompromised patients.

    abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...

    journal_title:Future microbiology



    authors: Maertens J,Bryan J

    更新日期:2010-12-01 00:00:00

  • γ-irradiation from radiotherapy improves the virulence potential of Candida tropicalis.

    abstract:AIM:To evaluate if radiation used in radiotherapy can cause changes in the virulence potential of Candida tropicalis ATCC 750. MATERIALS & METHODS:C. tropicalis was exposed in vitro to identical dose and scheme of irradiation would be used in patients with head and neck cancer. Some virulence parameters were analyzed ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: da Silva EM,Kischkel B,Shinobu-Mesquita CS,Bonfim-Mendonça PS,Mansano ES,da Silva MA,Barbosa JF,Fiorini A,Hernandes L,Furlaneto MC,Svidzinski TI

    更新日期:2017-12-01 00:00:00

  • Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy.

    abstract::Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rolando M,Buchrieser C

    更新日期:2012-03-01 00:00:00

  • Bioguided identification of antimicrobial compounds from Chrysopogon zizaniodes (L.) Roberty root essential oil.

    abstract::Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ramírez-Rueda RY,Marinho J,Salvador MJ

    更新日期:2019-09-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • Helicobacter pylori virulence factors in development of gastric carcinoma.

    abstract::Helicobacter pylori plays a vital role in the pathogenesis of gastric carcinoma. However, only a relatively small proportion of individuals infected with H. pylori develop gastric carcinoma. Differences in the incidence of gastric carcinoma among infected individuals can be explained, at least partly, by the different...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Wang MY,Liu XF,Gao XZ

    更新日期:2015-01-01 00:00:00

  • Evaluation of fosfomycin activity against uropathogens in a fosfomycin-naive population in South India: a prospective study.

    abstract:AIM:The aim was to evaluate the in vitro activity of fosfomycin against common uropathogens in a fosfomycin-naive population in India. METHODS:The authors prospectively collected and tested all consecutive isolates of Escherichia coli and Enterococcus spp. from urine samples between December 2009 and April 2010. RESU...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Sahni RD,Balaji V,Varghese R,John J,Tansarli GS,Falagas ME

    更新日期:2013-05-01 00:00:00

  • Better than a pound of cure: preventing the development of multidrug-resistant tuberculosis.

    abstract::Diagnostic and treatment delays contribute to increased death and disability among the 490,000 adults and children who develop multidrug-resistant (MDR) tuberculosis every year. Since the treatment of MDR tuberculosis is complex, costly and often toxic, tuberculosis control programs should prioritize strategies to pre...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Byrne AL,Fox GJ,Marais BJ

    更新日期:2018-04-01 00:00:00

  • Combination antifungal therapy: the new frontier.

    abstract::The past decade has seen a significant increase in the incidence of invasive fungal infections. The antifungal armamentarium for the treatment of serious fungal infections remains limited. A possible approach to overcoming antifungal drug resistance and high mortality rates seen in severe fungal infections is to combi...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Vazquez JA

    更新日期:2007-04-01 00:00:00

  • Vitamin B(12) metabolism in Mycobacterium tuberculosis.

    abstract::Mycobacterium tuberculosis is included among a select group of bacteria possessing the capacity for de novo biosynthesis of vitamin B12, the largest and most complex natural organometallic cofactor. The bacillus is also able to scavenge B12 and related corrinoids utilizing an ATP-binding cassette-type protein that is ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Gopinath K,Moosa A,Mizrahi V,Warner DF

    更新日期:2013-11-01 00:00:00

  • Delafloxacin: an improved fluoroquinolone developed through advanced molecular engineering.

    abstract::The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challeng...

    journal_title:Future microbiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bassetti M,Righi E,Pecori D,Tillotson G

    更新日期:2018-08-01 00:00:00

  • Histoplasma capsulatum, lung infection and immunity.

    abstract::Histoplasma capsulatum, an environmental fungus, is the most common endemic pulmonary mycosis in the USA. Disease is most frequently observed in immunocompromised patients living in endemic areas. We present the mechanisms of fungal recognition, innate immune response and adaptive immune response that lead to protecti...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Horwath MC,Fecher RA,Deepe GS Jr

    更新日期:2015-01-01 00:00:00

  • Epidemiology and virulence insights from MRSA and MSSA genome analysis.

    abstract::Staphylococcus aureus is a major human pathogen responsible for a wide diversity of infections ranging from localized to life threatening diseases. From 1961 and the emergence of methicillin-resistant S. aureus (MRSA), this bacterium has shown a particular capacity to survive and adapt to drastic environmental changes...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Lazarevic V,Beaume M,Corvaglia A,Hernandez D,Schrenzel J,François P

    更新日期:2011-05-01 00:00:00

  • How Cryptococcus interacts with the blood-brain barrier.

    abstract::Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Tseng HK,Huang TY,Wu AY,Chen HH,Liu CP,Jong A

    更新日期:2015-01-01 00:00:00

  • Myxopyronin: a punch in the jaws of bacterial RNA polymerase.

    abstract::Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tupin A,Gualtieri M,Brodolin K,Leonetti JP

    更新日期:2009-03-01 00:00:00

  • Potentially pathogenic amoeba-associated microorganisms in cooling towers and their control.

    abstract::Cooling towers provide a favorable environment for the proliferation of microorganisms. Cooling towers generate a biofilm and often aerosolize contaminated water, thereby increasing the risk of microorganism dissemination by human inhalation. This pathogen dissemination was first revealed by the epidemics of Legionnai...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Pagnier I,Merchat M,La Scola B

    更新日期:2009-06-01 00:00:00

  • Tuberculosis drugs: new candidates and how to find more.

    abstract::The recent years have witnessed significant progress in the development of new drug candidates for the treatment of TB. While many of these are now in clinical trials, continued research is needed in order to sustain the drug discovery pipeline and meet the increasing needs of TB patients. These include shortening tre...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Sala C,Hartkoorn RC

    更新日期:2011-06-01 00:00:00

  • The gut microbiome and the potentials of probiotics: an interview with Simon Gaisford.

    abstract::In this exclusive interview, Simon Gaisford discusses his current research into gut dysbiosis and its possible relevance to disease states, as well as the efficacy of probiotic supplementation and its possible use as treatment. This interview was conducted by Ellen Colvin, Commissioning Editor of Future Microbiology. ...

    journal_title:Future microbiology

    pub_type: 面试


    authors: Gaisford S

    更新日期:2019-03-01 00:00:00

  • COVID-19: mask efficacy is dependent on both fabric and fit.

    abstract::Aim: Face masks are an important addition to our arsenal in the fight against COVID-19. The aim of this study is to present a novel method of measuring mask performance which can simultaneously assess both fabric penetration and leakage due to poor fit. Materials & methods: A synthetic aerosol is introduced into the l...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Darby S,Chulliyallipalil K,Przyjalgowski M,McGowan P,Jeffers S,Giltinan A,Lewis L,Smith N,Sleator RD

    更新日期:2021-01-01 00:00:00

  • Repertoire of human breast and milk microbiota: a systematic review.

    abstract::Breastfeeding is a major determinant of human health. Breast milk is not sterile and ecological large-scale sequencing methods have revealed an unsuspected microbial diversity that plays an important role. However, microbiological analysis at the species level has been neglected while it is a prerequisite before under...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Togo A,Dufour JC,Lagier JC,Dubourg G,Raoult D,Million M

    更新日期:2019-05-01 00:00:00

  • Nosocomial infections in leukemic and solid-tumor cancer patients: distribution, outcome and microbial spectrum of anaerobes.

    abstract:AIMS:Nosocomial infections cause significant morbidity and mortality in cancer patients. As a result of their debilitated immune system, cancer patients are likely candidates for colonization with anaerobes. We sought to compare the distribution of nosocomial infections in neutropenic and non-neutropenic cancer patient...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: El-Sharif A,Elkhatib WF,Ashour HM

    更新日期:2012-12-01 00:00:00

  • Septic patients in the intensive care unit present different nasal microbiotas.

    abstract:AIM:The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS:A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS:The nasal microbiota in septic patients was dom...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Tan XL,Liu HY,Long J,Jiang Z,Luo Y,Zhao X,Cai S,Zhong X,Cen Z,Su J,Zhou H

    更新日期:2019-03-01 00:00:00

  • Molecular epidemiology of WU polyomavirus in hospitalized children with acute respiratory tract infection in China.

    abstract:AIM:To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. MATERIALS & METHODS:A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract i...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Zhu T,Lu QB,Zhang SY,Wo Y,Zhuang L,Zhang PH,Zhang XA,Wei W,Liu W

    更新日期:2017-05-01 00:00:00

  • Pseudomonas aeruginosa: my research passion. Interview by Hannah Branch.

    abstract::Linda Hazlett is a department chair and distinguished professor at Wayne State University (MI, USA). Her research is focused on the host immune response to Pseudomonas aeruginosa and its role in ocular infections. Dr Hazlett has been funded continuously by the NIH by R01 support for 34 years. She is currently principa...

    journal_title:Future microbiology

    pub_type: 面试


    authors: Hazlett L

    更新日期:2013-07-01 00:00:00

  • Imaging of Chlamydia and host cell metabolism.

    abstract::Chlamydial infections cause a wide range of acute and chronic diseases. Chlamydia trachomatis is the most common sexually transmitted bacterium while Chlamydia pneumoniae causes infections of the upper and lower respiratory tract. Chlamydia are obligate, intracellular bacteria with a biphasic developmental cycle that ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Käding N,Szaszák M,Rupp J

    更新日期:2014-01-01 00:00:00