The gallbladder and vermiform appendix influence the assemblage of intestinal microorganisms.

Abstract:

:Surgical procedures for the symptomatic removal of the gallbladder and the vermiform appendix have been posited to adversely shift the assemblage of the intestinal microbiome increasing the risk of disease. The associated mechanisms have been linked with dysbiosis of the gut microbiota. Cholecystectomy causes changes of bile acid compositions and bile secretion patterns as bile acids interact with the intestinal microbiota in a bidirectional capacity. An appendectomy precludes the further recolonization of the proximal colon with a commensal biofilm that could maintain a stable intestinal microbiome. Epidemiological studies indicate that there is an increased risk of disease rather than causality following a cholecystectomy and appendectomy. This narrative review summarizes studies that report on the role that bile salts and the appendix, contribute to the assemblage of the intestinal microbiome in health and disease.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Chen J,Sali A,Vitetta L

doi

10.2217/fmb-2019-0325

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

541-555

eissn

1746-0913

issn

1746-0921

journal_volume

15

pub_type

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