Pseudomonas aeruginosa: my research passion. Interview by Hannah Branch.

Abstract:

:Linda Hazlett is a department chair and distinguished professor at Wayne State University (MI, USA). Her research is focused on the host immune response to Pseudomonas aeruginosa and its role in ocular infections. Dr Hazlett has been funded continuously by the NIH by R01 support for 34 years. She is currently principal investigator of two R01 grants from the National Eye Institute that study pathogenesis of P. aeruginosa in the eye. Dr Hazlett oversees four Course Directors who lead Year 1 medical student teaching, in addition to two graduate course directors. Furthermore, although not involved in medical teaching, she educates graduate students and mentors a Research Scientist and a Research Assistant Professor. Throughout her career, Dr Hazlett has achieved several honors and awards including Distinguished Professor at Wayne State University (2008), National Eye Institute Core Center (P30) grant for 1987-2013, Chair of Physiology Search 2008-2009, Member of the Academy of Scholars at Wayne State University, Association for Research in Vision and Ophthalmology fellow at the Gold Medal level (2009) and was an invited speaker at the Gordon Conference 2010.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Hazlett L

doi

10.2217/fmb.13.49

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

833-4

issue

7

eissn

1746-0913

issn

1746-0921

journal_volume

8

pub_type

面试
  • Evaluation of different microtiter plate-based methods for the quantitative assessment of Staphylococcus aureus biofilms.

    abstract:AIM:To quantitatively assess Staphylococcus aureus biofilms. MATERIALS & METHODS:In addition to the qualitative Congo red agar (CRA) method, we used the bioluminescence (BLM), safranine (SAF), crystal violet (CRV) and resazurin (RES) high-throughput microtiter plate-based quantitative assays. RESULTS:60.47% (26/43) o...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.14.33

    authors: Elkhatib WF,Khairalla AS,Ashour HM

    更新日期:2014-01-01 00:00:00

  • Measles virus hemagglutinin epitopes are potential hotspots for crossreactions with immunodeficiency-related proteins.

    abstract:AIMS:Measles virus (MV) infection induces a protective immunity that is accompanied by a transient pathologic suppression of the immune system. This immunologic paradox remains unexplained in spite of the numerous hypotheses that have been advanced (i.e., cytokine production, soluble immunosuppressive factor, cell cycl...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.14.137

    authors: Kanduc D

    更新日期:2015-01-01 00:00:00

  • N-linked glycosylation in bacteria: an unexpected application.

    abstract::Traditionally, glycoproteins have been considered the exclusive property of eukaryotes and archaea, but it is now evident that glycoproteins are found in all domains of life. In recent years N-linked glycosylation among some epsilon-proteobacteria has emerged as a new and exciting research area and represents a useful...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.09.10

    authors: Langdon RH,Cuccui J,Wren BW

    更新日期:2009-05-01 00:00:00

  • The ferric uptake regulator of Helicobacter pylori: a critical player in the battle for iron and colonization of the stomach.

    abstract::Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.13.43

    authors: Pich OQ,Merrell DS

    更新日期:2013-06-01 00:00:00

  • Genetic and population analyses of Vibrio parahaemolyticus isolates from three major coastal regions in China.

    abstract:AIM:This study aims to evaluate the genetic and population structure of Vibrio parahaemolyticus in the major coastal regions of China. MATERIALS & METHODS:Multilocus sequence typing was performed. RESULTS:Insertion of large sequence into recA happened in nearly 30 strains, which were untypeable by multilocus sequence...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0060

    authors: Li P,Xin W,Kang L,Chen Z,Guo C,Gao S,Yang H,Ji B,Yan Y,Wang H,Zhou D,Yang W,Wang J

    更新日期:2018-09-01 00:00:00

  • Potential impact of removing metronidazole from treatment armamentarium of mild acute Clostridioides difficile infection.

    abstract::Aim: Recent guidelines recommended removing metronidazole as a therapeutic option for Clostridioides difficile infections (CDI). However, superiority of vancomycin over metronidazole in mild CDI is not established and use of vancomycin might lead to emergence of vancomycin-resistant enterococci (VRE). Patients & metho...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2019-0157

    authors: Zilberman-Itskovich S,Youngster I,Lazarovitch T,Bondarenco M,Toledano L,Kachlon Y,Mengesha B,Strul N,Zaidenstein R,Marchaim D

    更新日期:2019-11-01 00:00:00

  • Know your enemy: managing resistant Gram-negative infections.

    abstract::Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, t...

    journal_title:Future microbiology

    pub_type:

    doi:10.2217/fmb-2018-0202

    authors: Eckmann C,Rojas LJ,Lyon S

    更新日期:2018-10-01 00:00:00

  • Epigenetics in the unicellular parasite Entamoeba histolytica.

    abstract::Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.140

    authors: Tovy A,Ankri S

    更新日期:2010-12-01 00:00:00

  • Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates.

    abstract:AIM:To understand the relationship between ica, aap and bhp gene expression and the implications in biofilm formation in selected clinical and commensal Staphylococcus epidermidis isolates. MATERIAL & METHODS:Isolates were analyzed regarding their biofilm-forming capacity, biochemical matrix composition, biofilm spati...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2017-0140

    authors: Freitas AI,Lopes N,Oliveira F,Brás S,França Â,Vasconcelos C,Vilanova M,Cerca N

    更新日期:2018-03-01 00:00:00

  • Myxopyronin: a punch in the jaws of bacterial RNA polymerase.

    abstract::Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008) and, Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008). Bacteri...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/17460913.4.2.145

    authors: Tupin A,Gualtieri M,Brodolin K,Leonetti JP

    更新日期:2009-03-01 00:00:00

  • Nosocomial Gram-positive antimicrobial susceptibility pattern at a referral teaching hospital in Tehran, Iran.

    abstract:AIMS:The aim of the study was to evaluate epidemiology and susceptibility patterns of nosocomial Gram-positive infections in a referral teaching hospital. METHODS:Over a 1 year period, Gram-positive microorganisms isolated from specimens of hospitalized patients with documented nosocomial infection underwent antimicro...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.12.51

    authors: Soltani R,Khalili H,Abdollahi A,Rasoolinejad M,Dashti-Khavidaki S

    更新日期:2012-07-01 00:00:00

  • Histoplasma capsulatum, lung infection and immunity.

    abstract::Histoplasma capsulatum, an environmental fungus, is the most common endemic pulmonary mycosis in the USA. Disease is most frequently observed in immunocompromised patients living in endemic areas. We present the mechanisms of fungal recognition, innate immune response and adaptive immune response that lead to protecti...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.25

    authors: Horwath MC,Fecher RA,Deepe GS Jr

    更新日期:2015-01-01 00:00:00

  • Asaia lannensis bacteremia in a 'needle freak' patient.

    abstract::The genus Asaia has gained much interest lately owing to constant new species discoveries and its role as a potential opportunistic pathogen to humans. Here we describe a transient bacteremia due to Asaia lannensis in a patient with a psychiatric disorder (compulsive self-injection of different substances). Common phe...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.15.126

    authors: Carretto E,Visiello R,Bardaro M,Schivazappa S,Vailati F,Farina C,Barbarini D

    更新日期:2016-01-01 00:00:00

  • MAPK cell-cycle regulation in Saccharomyces cerevisiae and Candida albicans.

    abstract::The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-depende...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.72

    authors: Correia I,Alonso-Monge R,Pla J

    更新日期:2010-07-01 00:00:00

  • Clinical and molecular epidemiology of Acinetobacter baumannii bloodstream infections in an endemic setting.

    abstract:AIM:The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS:Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly a...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2016-0158

    authors: Marchaim D,Levit D,Zigron R,Gordon M,Lazarovitch T,Carrico JA,Chalifa-Caspi V,Moran-Gilad J

    更新日期:2017-03-01 00:00:00

  • Controversies in the treatment of pneumococcal community-acquired pneumonia.

    abstract::Community-acquired pneumonia remains an important cause of disease and death both in the developed and the developing worlds, despite the ready availability of potent antimicrobial agents to which the organisms remain susceptible. Furthermore, disease management is complicated by emerging resistance of the common path...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/17460913.1.3.271

    authors: Feldman C,Anderson R

    更新日期:2006-10-01 00:00:00

  • Folate metabolism as a source of molecular targets for antimalarials.

    abstract::Folate metabolism of the malaria parasites provides two targets for current antimalarials: dihydrofolate reductase and dihydropteroate synthase. Dihydrofolate reductase inhibitors have been used as antimalarials over the past few decades, often in combination with dihydropteroate synthase inhibitors. Resistance to the...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/17460913.1.1.113

    authors: Yuthavong Y,Kamchonwongpaisan S,Leartsakulpanich U,Chitnumsub P

    更新日期:2006-06-01 00:00:00

  • Evaluation of MALDI-TOF VITEK®MS and VITEK® 2 system for the identification of Staphylococcus saprophyticus.

    abstract:AIM:To compare two identification methods for coagulase-negative staphylococci (CoNS) isolated from patients with urinary tract infections, VITEK® 2 and MALDI-TOF VITEK®MS, with genotypic identification by internal transcribed spacer PCR (ITS-PCR). RESULTS:A total of 217 CoNS isolates were studied. Agreement of the VI...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0195

    authors: Martins KB,Ferreira AM,Mondelli AL,Rocchetti TT,Lr de S da Cunha M

    更新日期:2018-11-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.12.134

    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids.

    abstract:AIM:To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. METHODS & RESULTS:Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm forma...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.15.107

    authors: Bhargava N,Singh SP,Sharma A,Sharma P,Capalash N

    更新日期:2015-01-01 00:00:00

  • Report from the 4th Advances Against Aspergillosis Conference.

    abstract::Traditionally, the patients believed to be at highest risk of invasive aspergillosis (IA) are those who are neutropenic due to chemotherapy for hematological malignancy or those undergoing allogeneic hematopoietic stem cell transplantation. However, emerging data show that other patients are vulnerable to IA, even tho...

    journal_title:Future microbiology

    pub_type:

    doi:10.2217/fmb.10.73

    authors: Sheppard D,Grist LM

    更新日期:2010-07-01 00:00:00

  • Rotavirus disease and vaccination: impact on genotype diversity.

    abstract::Temporal and spatial fluctuations in the genotype distribution of human rotaviruses are continuously observed in surveillance studies. New genotypes, such as G9 and G12, have emerged and spread worldwide in a very short time span. In addition, reassortment events have the potential to contribute substantially to genet...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.09.96

    authors: Matthijnssens J,Bilcke J,Ciarlet M,Martella V,Bányai K,Rahman M,Zeller M,Beutels P,Van Damme P,Van Ranst M

    更新日期:2009-12-01 00:00:00

  • New insights into Prevotella diversity and medical microbiology.

    abstract::In light of recent studies based on cultivation-independent methods, it appears that the diversity of Prevotella in human microbiota is greater than was previously assumed from cultivation-based studies, and that the implication of these bacteria in several human diseases was unrecognized. While some Prevotella taxa w...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.126

    authors: Alauzet C,Marchandin H,Lozniewski A

    更新日期:2010-11-01 00:00:00

  • How Cryptococcus interacts with the blood-brain barrier.

    abstract::Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.83

    authors: Tseng HK,Huang TY,Wu AY,Chen HH,Liu CP,Jong A

    更新日期:2015-01-01 00:00:00

  • Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies.

    abstract::Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies includin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.165

    authors: Kato-Maeda M,Metcalfe JZ,Flores L

    更新日期:2011-02-01 00:00:00

  • Salmonella enterica as a vaccine carrier.

    abstract::Salmonella enterica is an invasive, facultative intracellular gastrointestinal pathogen causing human diseases such as gastroenteritis and typhoid fever. Virulence-attenuated strains of this pathogen have interesting capacities for the generation of live vaccines. Attenuated live typhoidal and nontyphoidal Salmonella ...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.11.144

    authors: Hegazy WA,Hensel M

    更新日期:2012-01-01 00:00:00

  • Methods for culturing anaerobes from human specimen.

    abstract::Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb-2017-0170

    authors: Guilhot E,Khelaifia S,La Scola B,Raoult D,Dubourg G

    更新日期:2018-03-01 00:00:00

  • A novel triterpene from Astraeus hygrometricus induces reactive oxygen species leading to death in Leishmania donovani.

    abstract:AIM:The effect of astrakurkurone, a novel triterpene, isolated from Indian mushroom Astraeus hygrometricus has been investigated to elucidate the mechanisms involved in selective cell death of Leishmania donovani. MATERIALS & METHODS:The hypotheses were investigated using flow-cytometry, scanning electron microscopy a...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.14.149

    authors: Mallick S,Dey S,Mandal S,Dutta A,Mukherjee D,Biswas G,Chatterjee S,Mallick S,Lai TK,Acharya K,Pal C

    更新日期:2015-01-01 00:00:00

  • Antibodies as a source of anti-infective peptides: an update.

    abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.36

    authors: Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

    更新日期:2015-01-01 00:00:00

  • Cryptococcus gattii infections: contemporary aspects of epidemiology, clinical manifestations and management of infection.

    abstract::Cryptococcus gattii is an important primary and opportunistic pathogen, predominantly causing meningoencephalitis and pulmonary disease with substantial mortality. Initially considered geographically restricted to immune-competent, highly exposed individuals in the tropics, an apparent epidemic in North America has le...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.13.123

    authors: McMullan BJ,Sorrell TC,Chen SC

    更新日期:2013-12-01 00:00:00