Pseudomonas aeruginosa: my research passion. Interview by Hannah Branch.


:Linda Hazlett is a department chair and distinguished professor at Wayne State University (MI, USA). Her research is focused on the host immune response to Pseudomonas aeruginosa and its role in ocular infections. Dr Hazlett has been funded continuously by the NIH by R01 support for 34 years. She is currently principal investigator of two R01 grants from the National Eye Institute that study pathogenesis of P. aeruginosa in the eye. Dr Hazlett oversees four Course Directors who lead Year 1 medical student teaching, in addition to two graduate course directors. Furthermore, although not involved in medical teaching, she educates graduate students and mentors a Research Scientist and a Research Assistant Professor. Throughout her career, Dr Hazlett has achieved several honors and awards including Distinguished Professor at Wayne State University (2008), National Eye Institute Core Center (P30) grant for 1987-2013, Chair of Physiology Search 2008-2009, Member of the Academy of Scholars at Wayne State University, Association for Research in Vision and Ophthalmology fellow at the Gold Medal level (2009) and was an invited speaker at the Gordon Conference 2010.


Future Microbiol


Future microbiology


Hazlett L




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2013-07-01 00:00:00












  • Antibodies as a source of anti-infective peptides: an update.

    abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

    更新日期:2015-01-01 00:00:00

  • Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids.

    abstract:AIM:To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. METHODS & RESULTS:Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm forma...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Bhargava N,Singh SP,Sharma A,Sharma P,Capalash N

    更新日期:2015-01-01 00:00:00

  • Dosing antibiotics in neonates: review of the pharmacokinetic data.

    abstract::Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or eff...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Rivera-Chaparro ND,Cohen-Wolkowiez M,Greenberg RG

    更新日期:2017-09-01 00:00:00

  • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.

    abstract:AIM:In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. MATERIALS & METHODS:Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Li N,Yin L,Thévenin D,Yamada Y,Limmon G,Chen J,Chow VT,Engelman DM,Engelward BP

    更新日期:2013-02-01 00:00:00

  • Oritavancin: a potential weapon in the battle against serious Gram-positive pathogens.

    abstract::Oritavancin is a lipoglycopeptide antibiotic with activity against aerobic and anaerobic Gram-positive bacteria. Oritavancin separates itself from other glycopeptides through its potent in vitro activity against resistant isolates of Staphylococcus aureus, Enterococcus spp. and Streptococcus spp. Oritavancin possesses...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Crandon J,Nicolau DP

    更新日期:2008-06-01 00:00:00

  • Bacterial triggering of inflammation by intracellular sensors.

    abstract::Recognition of bacterial infection is the first key step to the initiation of an inflammatory response and host defense. Transmembrane proteins of the Toll-like receptor family have long been recognized as key detectors of the extracellular presence of pathogens. Recently, much research has identified a variety of int...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Evans TJ

    更新日期:2009-02-01 00:00:00

  • Repertoire of human breast and milk microbiota: a systematic review.

    abstract::Breastfeeding is a major determinant of human health. Breast milk is not sterile and ecological large-scale sequencing methods have revealed an unsuspected microbial diversity that plays an important role. However, microbiological analysis at the species level has been neglected while it is a prerequisite before under...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Togo A,Dufour JC,Lagier JC,Dubourg G,Raoult D,Million M

    更新日期:2019-05-01 00:00:00

  • Technologies for the development of West Nile virus vaccines.

    abstract::West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic in an in...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Ulbert S,Magnusson SE

    更新日期:2014-01-01 00:00:00

  • Type B coxsackieviruses and their interactions with the innate and adaptive immune systems.

    abstract::Coxsackieviruses are important human pathogens, and their interactions with the innate and adaptive immune systems are of particular interest. Many viruses evade some aspects of the innate response, but coxsackieviruses go a step further by actively inducing, and then exploiting, some features of the host cell respons...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Kemball CC,Alirezaei M,Whitton JL

    更新日期:2010-09-01 00:00:00

  • The type IV secretion system in Helicobacter pylori.

    abstract::Helicobacter pylori (H. pylori) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, th...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Yuan XY,Wang Y,Wang MY

    更新日期:2018-07-01 00:00:00

  • Knowns and unknowns of influenza B viruses.

    abstract::Influenza B viruses (IBVs) circulate annually along with influenza A (IAV) strains during seasonal epidemics. IBV can dominate influenza seasons and cause severe disease, particularly in children and adolescents. Research has revealed interesting aspects of IBV and highlighted the importance of these viruses in clinic...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Koutsakos M,Nguyen TH,Barclay WS,Kedzierska K

    更新日期:2016-01-01 00:00:00

  • Bioguided identification of antimicrobial compounds from Chrysopogon zizaniodes (L.) Roberty root essential oil.

    abstract::Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ramírez-Rueda RY,Marinho J,Salvador MJ

    更新日期:2019-09-01 00:00:00

  • Clinical and molecular epidemiology of Acinetobacter baumannii bloodstream infections in an endemic setting.

    abstract:AIM:The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS:Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly a...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Marchaim D,Levit D,Zigron R,Gordon M,Lazarovitch T,Carrico JA,Chalifa-Caspi V,Moran-Gilad J

    更新日期:2017-03-01 00:00:00

  • Virulence factors in pneumococcal respiratory pathogenesis.

    abstract::Streptococcus pneumoniae (the pneumococcus) is a major global cause of human disease. Since the publication of the entire sequence of TIGR4 in 2001, our understanding of this human pathogen has increased significantly. Genetic studies, and the use of mutant strains have refined our understanding of the pathogenic mech...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Preston JA,Dockrell DH

    更新日期:2008-04-01 00:00:00

  • Cryptococcus neoformans glucuronoxylomannan fractions of different molecular masses are functionally distinct.

    abstract:AIMS:Glucuronoxylomannan (GXM) is the major polysaccharide component of Cryptococcus neoformans. We evaluated in this study whether GXM fractions of different molecular masses were functionally distinct. MATERIALS & METHODS:GXM samples isolated from C. neoformans cultures were fractionated to generate polysaccharide p...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Albuquerque PC,Fonseca FL,Dutra FF,Bozza MT,Frases S,Casadevall A,Rodrigues ML

    更新日期:2014-01-01 00:00:00

  • N-linked glycosylation in bacteria: an unexpected application.

    abstract::Traditionally, glycoproteins have been considered the exclusive property of eukaryotes and archaea, but it is now evident that glycoproteins are found in all domains of life. In recent years N-linked glycosylation among some epsilon-proteobacteria has emerged as a new and exciting research area and represents a useful...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Langdon RH,Cuccui J,Wren BW

    更新日期:2009-05-01 00:00:00

  • Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy.

    abstract::Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Rolando M,Buchrieser C

    更新日期:2012-03-01 00:00:00

  • Preclinical efficacy of a virus-like particle-based vaccine against avian influenza H5N1.

    abstract::Evaluation of: Kang S-M, Yoo D-G, Lipatov AS et al.: Induction of long-term protective immune responses by influenza H5N1 virus-like particles. PLoS ONE 4, e4667 (2009). This article describes a long-term protective effect of a vaccine candidate against avian influenza H5N1 that is based on A/Viet Nam1203/04 proteins ...

    journal_title:Future microbiology

    pub_type: 评论,杂志文章


    authors: Arnon R,Ben-Yedidia T

    更新日期:2009-06-01 00:00:00

  • Potential for adaptation overrides cost of resistance.

    abstract:AIM:To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. MATERIALS & METHODS:Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolution...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Moura de Sousa J,Sousa A,Bourgard C,Gordo I

    更新日期:2015-01-01 00:00:00

  • Comparison of antibiotic susceptibility of old and current Serratia.

    abstract:AIMS:We explored changes in antibiotic susceptibility of Serratia marcescens in the last 50 years by comparing isolates collected between 1945 and 1950, and current isolates. MATERIALS & METHODS:Isolates were divided into three groups: environmental, clinical and 'old'. Susceptibility was determined by microdilution. ...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Fusté E,Galisteo GJ,Jover L,Vinuesa T,Villa TG,Viñas M

    更新日期:2012-06-01 00:00:00

  • In vitro susceptibility testing in Aspergillus species: an update.

    abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Lass-Flörl C

    更新日期:2010-05-01 00:00:00

  • Cryptococcal infections in children: retrospective study and review from Australia.

    abstract::Aim: Cryptococcosis causes significant morbidity and mortality worldwide, but pediatric data are limited. Methods: A retrospective literature review of Australian pediatric cryptococcosis and additional 10-year audit of cases from a large pediatric network. Results: 22 cases of cryptococcosis in children were identifi...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Grimshaw A,Palasanthiran P,Huynh J,Marais B,Chen S,McMullan B

    更新日期:2019-12-01 00:00:00

  • Prospects for defined epitope vaccines for respiratory syncytial virus.

    abstract::The history of vaccines for respiratory syncytial virus (RSV) illustrates the complex immunity and immunopathology to this ubiquitous virus, starting from the failed formalin-inactivated vaccine trials performed in the 1960s. An attractive alternative to traditional live or killed virus vaccines is a defined vaccine c...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审


    authors: Anderson R,Huang Y,Langley JM

    更新日期:2010-04-01 00:00:00

  • Molecular epidemiology of WU polyomavirus in hospitalized children with acute respiratory tract infection in China.

    abstract:AIM:To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. MATERIALS & METHODS:A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract i...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Zhu T,Lu QB,Zhang SY,Wo Y,Zhuang L,Zhang PH,Zhang XA,Wei W,Liu W

    更新日期:2017-05-01 00:00:00

  • Raman spectroscopy: lighting up the future of microbial identification.

    abstract::Over the last decade Raman spectroscopy has become established as a physicochemical technique for the rapid identification of microbes. This powerful analytical method generates a spectroscopic fingerprint from the microbial sample, which provides quantitative and qualitative information that can be used to characteri...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Ashton L,Lau K,Winder CL,Goodacre R

    更新日期:2011-09-01 00:00:00

  • A novel triterpene from Astraeus hygrometricus induces reactive oxygen species leading to death in Leishmania donovani.

    abstract:AIM:The effect of astrakurkurone, a novel triterpene, isolated from Indian mushroom Astraeus hygrometricus has been investigated to elucidate the mechanisms involved in selective cell death of Leishmania donovani. MATERIALS & METHODS:The hypotheses were investigated using flow-cytometry, scanning electron microscopy a...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Mallick S,Dey S,Mandal S,Dutta A,Mukherjee D,Biswas G,Chatterjee S,Mallick S,Lai TK,Acharya K,Pal C

    更新日期:2015-01-01 00:00:00

  • Evaluation of MALDI-TOF VITEK®MS and VITEK® 2 system for the identification of Staphylococcus saprophyticus.

    abstract:AIM:To compare two identification methods for coagulase-negative staphylococci (CoNS) isolated from patients with urinary tract infections, VITEK® 2 and MALDI-TOF VITEK®MS, with genotypic identification by internal transcribed spacer PCR (ITS-PCR). RESULTS:A total of 217 CoNS isolates were studied. Agreement of the VI...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Martins KB,Ferreira AM,Mondelli AL,Rocchetti TT,Lr de S da Cunha M

    更新日期:2018-11-01 00:00:00

  • Comparative evaluation of GeneXpert MTB/RIF and multiplex PCR targeting mpb64 and IS6110 for the diagnosis of pleural TB.

    abstract:AIM:Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS:We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Sharma S,Dahiya B,Sreenivas V,Singh N,Raj A,Sheoran A,Yadav A,Gupta KB,Mehta PK

    更新日期:2018-03-01 00:00:00

  • Novel isoniazid derivative as promising antituberculosis agent.

    abstract::Background: A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of Mycobacterium tuberculosis. Results: We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward M. tuberculosis H37Rv and isoni...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Volynets GP,Tukalo MA,Bdzhola VG,Derkach NM,Gumeniuk MI,Tarnavskiy SS,Yarmoluk SM

    更新日期:2020-07-01 00:00:00

  • Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates.

    abstract:AIM:To understand the relationship between ica, aap and bhp gene expression and the implications in biofilm formation in selected clinical and commensal Staphylococcus epidermidis isolates. MATERIAL & METHODS:Isolates were analyzed regarding their biofilm-forming capacity, biochemical matrix composition, biofilm spati...

    journal_title:Future microbiology

    pub_type: 杂志文章


    authors: Freitas AI,Lopes N,Oliveira F,Brás S,França Â,Vasconcelos C,Vilanova M,Cerca N

    更新日期:2018-03-01 00:00:00