Abstract:
AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) renders cells sensitive to cell-wall-interfering drugs and, when overexpressed, Cek2 can become phosphorylated upon the same stimuli that activate Cek1. This is dependent on elements of the sterile-vegetative growth (SVG) pathway. Cek2, contrary to Cek1, mediates a transcriptional activity in a C. albicans-adapted two-hybrid system that is essential for Cek1-Cek2 interaction. CONCLUSION:Cek2 has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Correia I,Román E,Prieto D,Eisman B,Pla Jdoi
10.2217/fmb.15.127subject
Has Abstractpub_date
2016-01-01 00:00:00pages
51-67issue
1eissn
1746-0913issn
1746-0921journal_volume
11pub_type
杂志文章abstract::This paper analyzes the most recent reports regarding the direct and indirect effects of the 13-valent pneumococcal conjugate vaccine (PCV13) when administered to infants and young children. PCV13 extends the protective effects reported for the 7-valent pneumococcal conjugate vaccine (PCV7). A further reduction in the...
journal_title:Future microbiology
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journal_title:Future microbiology
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更新日期:2017-03-01 00:00:00
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Future microbiology
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更新日期:2018-12-01 00:00:00