Dosing antibiotics in neonates: review of the pharmacokinetic data.

Abstract:

:Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or efficacy failures in neonates. Driven by these differences and recent legislation mandating the study of drugs in children and neonates, an increasing number of pharmacokinetic studies of antibiotics are being performed in neonates. These studies have led to new dosing recommendations with particular consideration for neonate body size and maturation. Herein, we highlight the available pharmacokinetic data for commonly used systemic antibiotics in neonates.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Rivera-Chaparro ND,Cohen-Wolkowiez M,Greenberg RG

doi

10.2217/fmb-2017-0058

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

1001-1016

eissn

1746-0913

issn

1746-0921

journal_volume

12

pub_type

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