Bioguided identification of antimicrobial compounds from Chrysopogon zizaniodes (L.) Roberty root essential oil.

Abstract:

:Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF). Through GC-MS identification, the fractions with the greatest similarity to the active thin-layer chromatography fraction were used to determinate the MIC. Results: The subfraction 8 from column chromatography was responsible for the best MIC for MRSA (62.5 μg/ml) and VREF (125 μg/ml). Five compounds possibly responsible for antimicrobial activity were preliminary identified. Conclusion: We suggest that Cedr-8-en-13-ol, could be the more relevant compound involved in the antimicrobial activity in this study.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Ramírez-Rueda RY,Marinho J,Salvador MJ

doi

10.2217/fmb-2019-0167

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1179-1189

eissn

1746-0913

issn

1746-0921

journal_volume

14

pub_type

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