Abstract:
AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached with the TUP1REP-RFPREP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. CONCLUSION:Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Román E,Huertas B,Prieto D,Díez-Orejas R,Pla Jdoi
10.2217/fmb-2018-0012subject
Has Abstractpub_date
2018-06-01 00:00:00pages
857-867eissn
1746-0913issn
1746-0921journal_volume
13pub_type
杂志文章abstract:AIM:To quantitatively assess Staphylococcus aureus biofilms. MATERIALS & METHODS:In addition to the qualitative Congo red agar (CRA) method, we used the bioluminescence (BLM), safranine (SAF), crystal violet (CRV) and resazurin (RES) high-throughput microtiter plate-based quantitative assays. RESULTS:60.47% (26/43) o...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.14.33
更新日期:2014-01-01 00:00:00
abstract::The human periodontium health is commonly compromised by chronic inflammatory conditions and has become a major public health concern. Dental plaque, the precursor of periodontal disease, is a complex biofilm consisting mainly of bacteria, but also archaea, protozoa, fungi and viruses. Viruses that specifically infect...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2016-0081
更新日期:2016-10-01 00:00:00
abstract::Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest preva...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2016-0200
更新日期:2017-07-01 00:00:00
abstract::Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.137
更新日期:2016-01-01 00:00:00
abstract::In this exclusive interview, Simon Gaisford discusses his current research into gut dysbiosis and its possible relevance to disease states, as well as the efficacy of probiotic supplementation and its possible use as treatment. This interview was conducted by Ellen Colvin, Commissioning Editor of Future Microbiology. ...
journal_title:Future microbiology
pub_type: 面试
doi:10.2217/fmb-2019-0016
更新日期:2019-03-01 00:00:00
abstract:AIM:Our aim is to investigate if the clusters of postsurgical mycobacterial infections, reported between 2004 and 2008 in seven geographically distant states in Brazil, were caused by a single mycobacterial strain. MATERIALS & METHODS:Available information from 929 surgical patients was obtained from local health auth...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.10.49
更新日期:2010-06-01 00:00:00
abstract::Temporal and spatial fluctuations in the genotype distribution of human rotaviruses are continuously observed in surveillance studies. New genotypes, such as G9 and G12, have emerged and spread worldwide in a very short time span. In addition, reassortment events have the potential to contribute substantially to genet...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.09.96
更新日期:2009-12-01 00:00:00
abstract::Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0275
更新日期:2020-07-01 00:00:00
abstract::Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.83
更新日期:2015-01-01 00:00:00
abstract::The outstanding ability of Acinetobacter baumannii to cause outbreaks and acquire multidrug resistance motivated the development of a plethora of typing techniques, which can help infection preventionists and hospital epidemiologists to more efficiently implement intervention controls. Nowadays, the world is witnessin...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2019-0134
更新日期:2019-08-01 00:00:00
abstract::Helicobacter pylori is arguably one of the most successful pathogens; it colonizes the stomachs of more than half of the human population. Colonization and persistence in such an inhospitable niche requires the presence of exquisite adaptive mechanisms. One of the proteins that contributes significantly to the remarka...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.43
更新日期:2013-06-01 00:00:00
abstract:AIMS:To investigate whether Cek2 (as Cek1) is involved in the biogenesis of the fungal cell wall and to uncover differences and similitudes between both proteins. MATERIALS & METHODS:We used molecular genetics to characterize the role of Cek2 in MTL-heterozygous cells. RESULTS:Deletion of CEK2 (similar to CEK1) rende...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.15.127
更新日期:2016-01-01 00:00:00
abstract::Oritavancin is a lipoglycopeptide antibiotic with activity against aerobic and anaerobic Gram-positive bacteria. Oritavancin separates itself from other glycopeptides through its potent in vitro activity against resistant isolates of Staphylococcus aureus, Enterococcus spp. and Streptococcus spp. Oritavancin possesses...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.3.3.251
更新日期:2008-06-01 00:00:00
abstract:AIM:To compare two identification methods for coagulase-negative staphylococci (CoNS) isolated from patients with urinary tract infections, VITEK® 2 and MALDI-TOF VITEK®MS, with genotypic identification by internal transcribed spacer PCR (ITS-PCR). RESULTS:A total of 217 CoNS isolates were studied. Agreement of the VI...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0195
更新日期:2018-11-01 00:00:00
abstract::Cryptococcus gattii is an important primary and opportunistic pathogen, predominantly causing meningoencephalitis and pulmonary disease with substantial mortality. Initially considered geographically restricted to immune-competent, highly exposed individuals in the tropics, an apparent epidemic in North America has le...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.13.123
更新日期:2013-12-01 00:00:00
abstract::Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...
journal_title:Future microbiology
pub_type:
doi:10.2217/fmb.10.142
更新日期:2010-12-01 00:00:00
abstract:AIM:To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source. MATERIALS & METHODS:The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscop...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2018-0245
更新日期:2018-12-01 00:00:00
abstract:AIMS:Measles virus (MV) infection induces a protective immunity that is accompanied by a transient pathologic suppression of the immune system. This immunologic paradox remains unexplained in spite of the numerous hypotheses that have been advanced (i.e., cytokine production, soluble immunosuppressive factor, cell cycl...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb.14.137
更新日期:2015-01-01 00:00:00
abstract::There is evidence to link obesity (and metabolic syndrome) with alterations in gut permeability and microbiota. The underlying mechanisms have been questioned and have prompted this review. We propose that the gut barrier function is a primary driver in maintaining metabolic health with poor health being linked to 'gu...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/FMB.15.54
更新日期:2015-01-01 00:00:00
abstract::Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.14.98
更新日期:2015-01-01 00:00:00
abstract::Surgical procedures for the symptomatic removal of the gallbladder and the vermiform appendix have been posited to adversely shift the assemblage of the intestinal microbiome increasing the risk of disease. The associated mechanisms have been linked with dysbiosis of the gut microbiota. Cholecystectomy causes changes ...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2019-0325
更新日期:2020-05-01 00:00:00
abstract:AIM:To investigate the collective resistance of the bacteria population with resistant horizontal gene transfer under sublethal bactericide pressure. MATERIALS & METHODS:By employing qualitative analysis of ordinary differential equations, particularly bifurcation theory and several numerical simulations, a modified 4...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2017-0070
更新日期:2018-02-01 00:00:00
abstract::Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.12.9
更新日期:2012-03-01 00:00:00
abstract::The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challeng...
journal_title:Future microbiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2217/fmb-2018-0067
更新日期:2018-08-01 00:00:00
abstract:AIM:To evaluate alterations of zinc homeostasis in macrophages exposed to Cryptococcus neoformans. Materials & methods: Using a fluorescent zinc probe-based flow cytometry and atomic absorption spectrometry, zinc levels were evaluated in J774.A1 cell lines exposed to C. neoformans H99 cells. The transcription profile o...
journal_title:Future microbiology
pub_type: 杂志文章
doi:10.2217/fmb-2016-0160
更新日期:2017-05-01 00:00:00
abstract::Helicobacter pylori plays a vital role in the pathogenesis of gastric carcinoma. However, only a relatively small proportion of individuals infected with H. pylori develop gastric carcinoma. Differences in the incidence of gastric carcinoma among infected individuals can be explained, at least partly, by the different...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.15.72
更新日期:2015-01-01 00:00:00
abstract::Micafungin is a new drug in the echinocandin class and is currently being investigated in Phase III clinical trials. Like other echinocandins, it inhibits 1,3-beta-D-glucan synthesis, thus achieving fungicidal activity against virtually all Candida spp., including those resistant to fluconazole, and fungistatic activi...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/17460913.1.2.161
更新日期:2006-08-01 00:00:00
abstract::Helicobacter pylori (H. pylori) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, th...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb-2018-0038
更新日期:2018-07-01 00:00:00
abstract::Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.140
更新日期:2010-12-01 00:00:00
abstract::The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and Shigella, Chlamydia injects effector proteins into epithelial cells to initiate extensive remodeling of the actin cytoskeleton at the bacterial ...
journal_title:Future microbiology
pub_type: 杂志文章,评审
doi:10.2217/fmb.10.77
更新日期:2010-08-01 00:00:00