How Cryptococcus interacts with the blood-brain barrier.

Abstract:

:Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which are the main constitute of the BBB, or go in between tight junctions. Recent evidence of human brain microvascular endothelial cell responses to transcellular brain invasions includes membrane rearrangements, intracellular signaling pathways and cytoskeletal activations. Several Cryptococcal genes related to the traversal of BBB have been identified, including CPS1, ITR1a, ITR3c, PLB1, MPR1, FNX1 and RUB1. In addition, Cryptococcus neoformans-derived microvesicles may contribute to cryptococcal brain invasion. Paracellularly, Cryptococcus may traverse across BBB using either routes utilizing plasmin, ammonia or macrophages in a Trojan horse mechanism.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Tseng HK,Huang TY,Wu AY,Chen HH,Liu CP,Jong A

doi

10.2217/fmb.15.83

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1669-82

issue

10

eissn

1746-0913

issn

1746-0921

journal_volume

10

pub_type

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