Abstract:
:Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood-brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which are the main constitute of the BBB, or go in between tight junctions. Recent evidence of human brain microvascular endothelial cell responses to transcellular brain invasions includes membrane rearrangements, intracellular signaling pathways and cytoskeletal activations. Several Cryptococcal genes related to the traversal of BBB have been identified, including CPS1, ITR1a, ITR3c, PLB1, MPR1, FNX1 and RUB1. In addition, Cryptococcus neoformans-derived microvesicles may contribute to cryptococcal brain invasion. Paracellularly, Cryptococcus may traverse across BBB using either routes utilizing plasmin, ammonia or macrophages in a Trojan horse mechanism.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Tseng HK,Huang TY,Wu AY,Chen HH,Liu CP,Jong Adoi
10.2217/fmb.15.83subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1669-82issue
10eissn
1746-0913issn
1746-0921journal_volume
10pub_type
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更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.2217/17460913.3.3.351
更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Future microbiology
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章
doi:10.2217/fmb.12.51
更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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journal_title:Future microbiology
pub_type: 评论,杂志文章
doi:10.2217/fmb.09.33
更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
doi:10.2217/fmb-2016-0160
更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
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更新日期:2016-01-01 00:00:00