Measles virus hemagglutinin epitopes are potential hotspots for crossreactions with immunodeficiency-related proteins.

Abstract:

AIMS:Measles virus (MV) infection induces a protective immunity that is accompanied by a transient pathologic suppression of the immune system. This immunologic paradox remains unexplained in spite of the numerous hypotheses that have been advanced (i.e., cytokine production, soluble immunosuppressive factor, cell cycle block, signaling lymphocyte activation molecule receptor and MV infection of dendritic cells, among others). METHODS:Searching for molecular link(s) between MV infection and host immunodeficiency, this study used the Immune Epitope DataBase to analyze the peptide sharing between the antigenic MV hemagglutinin (H) protein and human proteins associated with immunodeficiency. RESULTS:It was found that the majority of MVH derived epitopes share several exact pentapeptide sequences with numerous human proteins involved in immune functions and immunodeficiency, such as B- and T-cell antigens, and complement components. CONCLUSION:The data suggest that crossreactivity might contribute to our understanding of the link between MV immunogenicity and MV-induced immunosuppression, and highlight peptides unique to MV as a basis for developing effective and safe anti-MV vaccines.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Kanduc D

doi

10.2217/fmb.14.137

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

503-15

issue

4

eissn

1746-0913

issn

1746-0921

journal_volume

10

pub_type

杂志文章
  • Fusarium oxysporum is an onychomycosis etiopathogenic agent.

    abstract:AIM:To evaluate and characterize the etiopathogenesis of the fusarial onychomycosis in an ex vivo study through fragments of sterile human nail, without the addition of any nutritional source. MATERIALS & METHODS:The infection and invasion of Fusarium oxysporum in the nail were evaluated by scanning electron microscop...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0245

    authors: Veiga FF,de Castro-Hoshino LV,Sato F,Bombassaro A,Vicente VA,Mendes V,Baesso ML,Negri M,Svidzinski TI

    更新日期:2018-12-01 00:00:00

  • Evaluation of fosfomycin activity against uropathogens in a fosfomycin-naive population in South India: a prospective study.

    abstract:AIM:The aim was to evaluate the in vitro activity of fosfomycin against common uropathogens in a fosfomycin-naive population in India. METHODS:The authors prospectively collected and tested all consecutive isolates of Escherichia coli and Enterococcus spp. from urine samples between December 2009 and April 2010. RESU...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.13.31

    authors: Sahni RD,Balaji V,Varghese R,John J,Tansarli GS,Falagas ME

    更新日期:2013-05-01 00:00:00

  • COVID-19: mask efficacy is dependent on both fabric and fit.

    abstract::Aim: Face masks are an important addition to our arsenal in the fight against COVID-19. The aim of this study is to present a novel method of measuring mask performance which can simultaneously assess both fabric penetration and leakage due to poor fit. Materials & methods: A synthetic aerosol is introduced into the l...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2020-0292

    authors: Darby S,Chulliyallipalil K,Przyjalgowski M,McGowan P,Jeffers S,Giltinan A,Lewis L,Smith N,Sleator RD

    更新日期:2021-01-01 00:00:00

  • Cryptococcus neoformans glucuronoxylomannan fractions of different molecular masses are functionally distinct.

    abstract:AIMS:Glucuronoxylomannan (GXM) is the major polysaccharide component of Cryptococcus neoformans. We evaluated in this study whether GXM fractions of different molecular masses were functionally distinct. MATERIALS & METHODS:GXM samples isolated from C. neoformans cultures were fractionated to generate polysaccharide p...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.13.163

    authors: Albuquerque PC,Fonseca FL,Dutra FF,Bozza MT,Frases S,Casadevall A,Rodrigues ML

    更新日期:2014-01-01 00:00:00

  • The CRISPR-cas system promotes antimicrobial resistance in Campylobacter jejuni.

    abstract:AIM:The purpose of current study is to find out relationship between cas9 gene and antimicrobial resistance in Campylobacter jejuni NCTC11168. MATERIALS & METHODS:The involvement of the cas9 gene in antimicrobial resistance of C. jejuni was determined by assessment of minimum inhibitory concentration, clustered regula...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0234

    authors: Shabbir MA,Wu Q,Shabbir MZ,Sajid A,Ahmed S,Sattar A,Tang Y,Li J,Maan MK,Hao H,Yuan Z

    更新日期:2018-12-01 00:00:00

  • Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.

    abstract:AIMS:To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. MATERIALS & METHODS:The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were inte...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.15.66

    authors: Chen ZF,Ai LY,Wang JL,Ren LL,Yu YN,Xu J,Chen HY,Yu J,Li M,Qin WX,Ma X,Shen N,Chen YX,Hong J,Fang JY

    更新日期:2015-01-01 00:00:00

  • Prospects for defined epitope vaccines for respiratory syncytial virus.

    abstract::The history of vaccines for respiratory syncytial virus (RSV) illustrates the complex immunity and immunopathology to this ubiquitous virus, starting from the failed formalin-inactivated vaccine trials performed in the 1960s. An attractive alternative to traditional live or killed virus vaccines is a defined vaccine c...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.22

    authors: Anderson R,Huang Y,Langley JM

    更新日期:2010-04-01 00:00:00

  • In vitro susceptibility testing in Aspergillus species: an update.

    abstract::Aspergillus species are the most common causes of invasive mold infections in immunocompromised patients. The introduction of new antifungal agents and recent reports of resistance emerging during treatment of Aspergillus infections have highlighted the need for in vitro susceptibility testing. Various testing procedu...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.34

    authors: Lass-Flörl C

    更新日期:2010-05-01 00:00:00

  • Origin of hepatitis delta virus.

    abstract::This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent t...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.15

    authors: Taylor J,Pelchat M

    更新日期:2010-03-01 00:00:00

  • Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies.

    abstract::Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies includin...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.10.165

    authors: Kato-Maeda M,Metcalfe JZ,Flores L

    更新日期:2011-02-01 00:00:00

  • Characterization of unrelated clinical Legionella pneumophila isolates in Catalonia by monoclonal subgrouping and sequence-based typing.

    abstract:AIM:To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. METHODS:95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. RESULTS:The isolates showed a high diversity (IOD 0.964) w...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2016-0013

    authors: Garcia-Nuñez M,Quero S,Pedro-Botet ML,Barrabeig I,Avarez J,Campoy I,Sala MR,Parraga-Niño N,Minguell S,Caylà J,Mateu L,Sabria M

    更新日期:2016-07-01 00:00:00

  • Pre-implementation guidelines for infectious disease point-of-care testing in medical institutions.

    abstract::Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-imp...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2016-0120

    authors: van der Eijk AA,Tintu AN,Hays JP

    更新日期:2017-01-01 00:00:00

  • Accurate differentiation of novel Staphylococcus argenteus from Staphylococcus aureus using MALDI-TOF MS.

    abstract:AIM:We evaluated a Staphylococcus argenteus-specific diagnostic profile of matrix-assisted laser desorption/ionization time-of-flight mass spectrometer for accurate identification of this novel bacterium. MATERIALS & METHODS:Staphylococcus argenteus was identified based on negative crtM gene and presence of specific s...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0015

    authors: Chen SY,Lee H,Teng SH,Wang XM,Lee TF,Huang YC,Liao CH,Teng LJ,Hsueh PR

    更新日期:2018-07-01 00:00:00

  • Epidemic of surgical-site infections by a single clone of rapidly growing mycobacteria in Brazil.

    abstract:AIM:Our aim is to investigate if the clusters of postsurgical mycobacterial infections, reported between 2004 and 2008 in seven geographically distant states in Brazil, were caused by a single mycobacterial strain. MATERIALS & METHODS:Available information from 929 surgical patients was obtained from local health auth...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.10.49

    authors: Leão SC,Viana-Niero C,Matsumoto CK,Lima KV,Lopes ML,Palaci M,Hadad DJ,Vinhas S,Duarte RS,Lourenço MC,Kipnis A,das Neves ZC,Gabardo BM,Ribeiro MO,Baethgen L,de Assis DB,Madalosso G,Chimara E,Dalcolmo MP

    更新日期:2010-06-01 00:00:00

  • Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.

    abstract::Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal structures to guide new discovery of antibiotics that are effective aga...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.78

    authors: Reeve SM,Lombardo MN,Anderson AC

    更新日期:2015-01-01 00:00:00

  • Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids.

    abstract:AIM:To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. METHODS & RESULTS:Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm forma...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.15.107

    authors: Bhargava N,Singh SP,Sharma A,Sharma P,Capalash N

    更新日期:2015-01-01 00:00:00

  • Current status and future perspectives on molecular and serological methods in diagnostic mycology.

    abstract::Invasive fungal infections are an important cause of infectious morbidity. Nonculture-based methods are increasingly used for rapid, accurate diagnosis to improve patient outcomes. New and existing DNA amplification platforms have high sensitivity and specificity for direct detection and identification of fungi in cli...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.09.70

    authors: Lau A,Chen S,Sleiman S,Sorrell T

    更新日期:2009-11-01 00:00:00

  • Antibodies as a source of anti-infective peptides: an update.

    abstract::This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune syste...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.36

    authors: Magliani W,Giovati L,Ciociola T,Sperindè M,Santinoli C,Conti G,Conti S,Polonelli L

    更新日期:2015-01-01 00:00:00

  • Differentiation between Staphylococcus aureus and Staphylococcus epidermidis strains using Raman spectroscopy.

    abstract:AIM:Raman spectroscopy is an analytical method with a broad range of applications across multiple scientific fields. We report on a possibility to differentiate between two important Gram-positive species commonly found in clinical material - Staphylococcus aureus and Staphylococcus epidermidis - using this rapid nonin...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2016-0224

    authors: Rebrošová K,Šiler M,Samek O,Růžička F,Bernatová S,Ježek J,Zemánek P,Holá V

    更新日期:2017-08-01 00:00:00

  • Cif type III effector protein: a smart hijacker of the host cell cycle.

    abstract::During coevolution with their hosts, bacteria have developed functions that allow them to interfere with the mechanisms controlling the proliferation of eukaryotic cells. Cycle inhibiting factor (Cif) is one of these cyclomodulins, the family of bacterial effectors that interfere with the host cell cycle. Acquired ear...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.09.60

    authors: Samba-Louaka A,Taieb F,Nougayrède JP,Oswald E

    更新日期:2009-09-01 00:00:00

  • The contribution of genomics to the study of Q fever.

    abstract::Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.15.137

    authors: D'Amato F,Eldin C,Raoult D

    更新日期:2016-01-01 00:00:00

  • Impact of fluoroquinolones on human microbiota. Focus on the emergence of antibiotic resistance.

    abstract::The aggregate of microorganisms residing on the surface of the skin, in the oropharynx and in the GI tract, known as the human microbiota, play a major role as natural reservoirs for bacterial resistance to antibiotics. Fluoroquinolones (FQ) are among the most prescribed antibiotics and a major increase in FQ resistan...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.40

    authors: de Lastours V,Fantin B

    更新日期:2015-01-01 00:00:00

  • Letermovir for prophylaxis of cytomegalovirus manifestations in adult allogeneic hematopoietic stem cell transplant recipients.

    abstract::Cytomegalovirus (CMV) manifestations remain important complications after allogeneic hematopoietic stem cell transplantation (HSCT), even in the current era. Unfortunately, available anti-CMV agents, mainly viral polymerase inhibitors, have a substantial risk of myelosuppression and nephrotoxicity. Letermovir, a novel...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0250

    authors: Hecke SV,Calcoen B,Lagrou K,Maertens J

    更新日期:2019-02-01 00:00:00

  • Knowns and unknowns of influenza B viruses.

    abstract::Influenza B viruses (IBVs) circulate annually along with influenza A (IAV) strains during seasonal epidemics. IBV can dominate influenza seasons and cause severe disease, particularly in children and adolescents. Research has revealed interesting aspects of IBV and highlighted the importance of these viruses in clinic...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.15.120

    authors: Koutsakos M,Nguyen TH,Barclay WS,Kedzierska K

    更新日期:2016-01-01 00:00:00

  • Natural history of Bartonella-infecting rodents in light of new knowledge on genomics, diversity and evolution.

    abstract::Among the 33 confirmed Bartonella species to date, more than half are hosted by rodent species, and at least five of them have been involved in human illness causing diverse symptoms including fever, myocarditis, endocarditis, lymphadenitis and hepatitis. In almost all countries, wild rodents are infected by extremely...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.13.77

    authors: Buffet JP,Kosoy M,Vayssier-Taussat M

    更新日期:2013-09-01 00:00:00

  • Comparison of antibiotic susceptibility of old and current Serratia.

    abstract:AIMS:We explored changes in antibiotic susceptibility of Serratia marcescens in the last 50 years by comparing isolates collected between 1945 and 1950, and current isolates. MATERIALS & METHODS:Isolates were divided into three groups: environmental, clinical and 'old'. Susceptibility was determined by microdilution. ...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb.12.40

    authors: Fusté E,Galisteo GJ,Jover L,Vinuesa T,Villa TG,Viñas M

    更新日期:2012-06-01 00:00:00

  • The type IV secretion system in Helicobacter pylori.

    abstract::Helicobacter pylori (H. pylori) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, th...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb-2018-0038

    authors: Yuan XY,Wang Y,Wang MY

    更新日期:2018-07-01 00:00:00

  • TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.

    abstract:AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached w...

    journal_title:Future microbiology

    pub_type: 杂志文章

    doi:10.2217/fmb-2018-0012

    authors: Román E,Huertas B,Prieto D,Díez-Orejas R,Pla J

    更新日期:2018-06-01 00:00:00

  • Staphylococcal disease in Africa: another neglected 'tropical' disease.

    abstract::The term 'neglected tropical diseases' predominantly refers to single-entity, mostly parasitic diseases. However, a considerable morbidity and mortality burden is carried by patients infected with Gram-positive cocci and Gram-negative bacilli that are prevalent all over the world, yet have impact in tropical and devel...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/fmb.12.126

    authors: Herrmann M,Abdullah S,Alabi A,Alonso P,Friedrich AW,Fuhr G,Germann A,Kern WV,Kremsner PG,Mandomando I,Mellmann AC,Pluschke G,Rieg S,Ruffing U,Schaumburg F,Tanner M,Peters G,von Briesen H,von Eiff C,von Müller L,Gr

    更新日期:2013-01-01 00:00:00

  • Antibiotic-associated diarrhea: epidemiology, trends and treatment.

    abstract::A common complication of antibiotic use is the development of gastrointestinal disease. This complication ranges from mild diarrhea to pseudomembranous colitis. Outbreaks of antibiotic-associated diarrhea (AAD) may also occur in healthcare settings, usually caused by Clostridium difficile. AAD typically occurs in 5-35...

    journal_title:Future microbiology

    pub_type: 杂志文章,评审

    doi:10.2217/17460913.3.5.563

    authors: McFarland LV

    更新日期:2008-10-01 00:00:00