Histoplasma capsulatum, lung infection and immunity.

Abstract:

:Histoplasma capsulatum, an environmental fungus, is the most common endemic pulmonary mycosis in the USA. Disease is most frequently observed in immunocompromised patients living in endemic areas. We present the mechanisms of fungal recognition, innate immune response and adaptive immune response that lead to protection or exacerbation of disease. Current understanding of these mechanisms is the result of a continuing dialogue between clinical observations and murine studies. Mice are a powerful model to study the immune response to H. capsulatum alone or in the presence of immunomodulatory drugs. Vigilance for histoplasmosis should be exercised with novel immunosuppressive agents that target the important immune pathways identified here.

journal_name

Future Microbiol

journal_title

Future microbiology

authors

Horwath MC,Fecher RA,Deepe GS Jr

doi

10.2217/fmb.15.25

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

967-75

issue

6

eissn

1746-0913

issn

1746-0921

journal_volume

10

pub_type

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