Abstract:
:Histoplasma capsulatum, an environmental fungus, is the most common endemic pulmonary mycosis in the USA. Disease is most frequently observed in immunocompromised patients living in endemic areas. We present the mechanisms of fungal recognition, innate immune response and adaptive immune response that lead to protection or exacerbation of disease. Current understanding of these mechanisms is the result of a continuing dialogue between clinical observations and murine studies. Mice are a powerful model to study the immune response to H. capsulatum alone or in the presence of immunomodulatory drugs. Vigilance for histoplasmosis should be exercised with novel immunosuppressive agents that target the important immune pathways identified here.
journal_name
Future Microbioljournal_title
Future microbiologyauthors
Horwath MC,Fecher RA,Deepe GS Jrdoi
10.2217/fmb.15.25subject
Has Abstractpub_date
2015-01-01 00:00:00pages
967-75issue
6eissn
1746-0913issn
1746-0921journal_volume
10pub_type
杂志文章,评审abstract::A common complication of antibiotic use is the development of gastrointestinal disease. This complication ranges from mild diarrhea to pseudomembranous colitis. Outbreaks of antibiotic-associated diarrhea (AAD) may also occur in healthcare settings, usually caused by Clostridium difficile. AAD typically occurs in 5-35...
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更新日期:2015-01-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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