Bacterial triggering of inflammation by intracellular sensors.

abstract：:Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules, thereby perturbing bacterial metabolism. Ga(III)-induced metabolic distresses a...

journal_title：Future microbiology

authors： Minandri F,Bonchi C,Frangipani E,Imperi F,Visca P

更新日期：2014-01-01 00:00:00

abstract：:Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. Methods: Twenty-eight nonduplicate CRAB isolates detected a...

journal_title：Future microbiology

authors： Osman M,B Halimeh F,Rafei R,Mallat H,Tom JE,Raad EB,M Diene S,Jamal S,Atrouni AA,Dabboussi F,Moudani W,Madec JY,Saras E,Lupo A,Haenni M,Rolain JM,Hamze M

更新日期：2020-10-01 00:00:00

abstract：AIM:The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata. METHODS & RESULTS:Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly a...

journal_title：Future microbiology

authors： Marchaim D,Levit D,Zigron R,Gordon M,Lazarovitch T,Carrico JA,Chalifa-Caspi V,Moran-Gilad J

更新日期：2017-03-01 00:00:00

abstract：:Celebrating its 30th anniversary in Budapest this year, the International Immunocompromised Host Society (ICHS) was established to advance the understanding of interactions between host defenses and microbial agents in order to improve the prevention and management of human disease in patients with compromised immune ...

journal_title：Future microbiology

authors： Maertens J,Bryan J

更新日期：2010-12-01 00:00:00

abstract：:Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of...

journal_title：Future microbiology

authors： D'Amato F,Eldin C,Raoult D

更新日期：2016-01-01 00:00:00

abstract：:Eukaryotic proteins are tightly regulated by post-translational modifications, leading to a very subtle degree of regulation in time and space. Pathogen-mediated post-translational modifications are key strategies to modulate host factors by targeting central signaling pathways in the host cell. Legionella pneumophila...

journal_title：Future microbiology

authors： Rolando M,Buchrieser C

更新日期：2012-03-01 00:00:00

abstract：:Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genoty...

journal_title：Future microbiology

authors： Dalton HR,Kamar N,Izopet J

更新日期：2014-01-01 00:00:00

abstract：AIM:To quantitatively assess Staphylococcus aureus biofilms. MATERIALS & METHODS:In addition to the qualitative Congo red agar (CRA) method, we used the bioluminescence (BLM), safranine (SAF), crystal violet (CRV) and resazurin (RES) high-throughput microtiter plate-based quantitative assays. RESULTS:60.47% (26/43) o...

journal_title：Future microbiology

authors： Elkhatib WF,Khairalla AS,Ashour HM

更新日期：2014-01-01 00:00:00

abstract：:Mycobacterium tuberculosis is included among a select group of bacteria possessing the capacity for de novo biosynthesis of vitamin B12, the largest and most complex natural organometallic cofactor. The bacillus is also able to scavenge B12 and related corrinoids utilizing an ATP-binding cassette-type protein that is ...

journal_title：Future microbiology

authors： Gopinath K,Moosa A,Mizrahi V,Warner DF

更新日期：2013-11-01 00:00:00

abstract：:Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might ...

journal_title：Future microbiology

authors： Gouzy A,Poquet Y,Neyrolles O

更新日期：2014-01-01 00:00:00

abstract：AIM:Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS:We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (...

journal_title：Future microbiology

authors： Sharma S,Dahiya B,Sreenivas V,Singh N,Raj A,Sheoran A,Yadav A,Gupta KB,Mehta PK

更新日期：2018-03-01 00:00:00

abstract：:Influenza B viruses (IBVs) circulate annually along with influenza A (IAV) strains during seasonal epidemics. IBV can dominate influenza seasons and cause severe disease, particularly in children and adolescents. Research has revealed interesting aspects of IBV and highlighted the importance of these viruses in clinic...

journal_title：Future microbiology

authors： Koutsakos M,Nguyen TH,Barclay WS,Kedzierska K

更新日期：2016-01-01 00:00:00

abstract：:Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review desc...

journal_title：Future microbiology

authors： Mancini N,Marrone L,Clementi N,Sautto GA,Clementi M,Burioni R

更新日期：2015-01-01 00:00:00

abstract：:Infections with Pseudomonas aeruginosa are a major health problem, especially for immune-compromised and cystic fibrosis patients, owing to the particular drug resistance of the microorganism. The aim of this review is to provide recent insights into strategies under investigation for prevention and therapy of these i...

journal_title：Future microbiology

authors： Savoia D

更新日期：2014-01-01 00:00:00

abstract：:Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation ...

journal_title：Future microbiology

authors： Guzmán-Téllez P,Martínez-Castillo M,Flores-Huerta N,Rosales-Morgan G,Pacheco-Yépez J,la Garza M,Serrano-Luna J,Shibayama M

更新日期：2020-07-01 00:00:00

abstract：:Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC...

journal_title：Future microbiology

authors： A Castaneda C,Castillo M,Sanchez J,Casavilca S,Sanchez J,A Bernabe L,Suarez N,Chavez I,Ruiz E,Tello K,R Villa M,Zevallos R,Montenegro P,Dias-Neto E,Landa-Baella M,Taxa L

更新日期：2020-08-01 00:00:00

abstract：:HCV is a major cause of chronic liver disease worldwide. There is no vaccine available and the current antiviral therapies fail to cure approximately half of treated patients. Liver disease caused by HCV infection is the most common indication for orthotopic liver transplantation. Unfortunately, reinfection of the new...

journal_title：Future microbiology

authors： Angus AG,Patel AH

更新日期：2011-03-01 00:00:00

abstract：:The genus Asaia has gained much interest lately owing to constant new species discoveries and its role as a potential opportunistic pathogen to humans. Here we describe a transient bacteremia due to Asaia lannensis in a patient with a psychiatric disorder (compulsive self-injection of different substances). Common phe...

journal_title：Future microbiology

authors： Carretto E,Visiello R,Bardaro M,Schivazappa S,Vailati F,Farina C,Barbarini D

更新日期：2016-01-01 00:00:00

abstract：:Cryptococcus gattii is an important primary and opportunistic pathogen, predominantly causing meningoencephalitis and pulmonary disease with substantial mortality. Initially considered geographically restricted to immune-competent, highly exposed individuals in the tropics, an apparent epidemic in North America has le...

journal_title：Future microbiology

authors： McMullan BJ,Sorrell TC,Chen SC

更新日期：2013-12-01 00:00:00

abstract：AIMS:This study aimed to evaluate the antimicrobial activity of two different formulations of bioglass BAG-S53P4 against multiresistant microorganisms involved in bone infections, and the capability of bioglass to select for resistance. METHODS:Antibacterial activity was evaluated by means of killing curves. The abili...

journal_title：Future microbiology

authors： Drago L,De Vecchi E,Bortolin M,Toscano M,Mattina R,Romanò CL

更新日期：2015-01-01 00:00:00

abstract：AIM:To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS:We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS:The colonization rates reached w...

journal_title：Future microbiology

authors： Román E,Huertas B,Prieto D,Díez-Orejas R,Pla J

更新日期：2018-06-01 00:00:00

abstract：:Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blin...

journal_title：Future microbiology

authors： Al-Dujaili LJ,Clerkin PP,Clement C,McFerrin HE,Bhattacharjee PS,Varnell ED,Kaufman HE,Hill JM

更新日期：2011-08-01 00:00:00

abstract：AIMS:Measles virus (MV) infection induces a protective immunity that is accompanied by a transient pathologic suppression of the immune system. This immunologic paradox remains unexplained in spite of the numerous hypotheses that have been advanced (i.e., cytokine production, soluble immunosuppressive factor, cell cycl...

journal_title：Future microbiology

authors： Kanduc D

更新日期：2015-01-01 00:00:00

abstract：:Aim: Multidrug-resistant Staphylococcus aureus isolates have become a serious concern in clinical microbiology. Antisense strategy, which specifically targets essential genes, could be helpful. Materials & methods:S. aureus cultures were treated with peptide conjugate-peptide nucleic acid (PPNA) specific for the gyrA ...

journal_title：Future microbiology

authors： Tavakoli M,Hashemi A,Vaezjalali M,Mohammadzadeh M,Goudarzi H

更新日期：2019-09-01 00:00:00

abstract：:Amoebiasis is a serious infectious disease that is caused by the unicellular parasite, Entamoeba histolytica. This parasite is mainly found in developing countries, and are named owing to its ability to destroy tissues. The molecular mechanisms that regulate the virulence of this parasite are not well understood. In r...

journal_title：Future microbiology

authors： Tovy A,Ankri S

更新日期：2010-12-01 00:00:00

abstract：:There is evidence to link obesity (and metabolic syndrome) with alterations in gut permeability and microbiota. The underlying mechanisms have been questioned and have prompted this review. We propose that the gut barrier function is a primary driver in maintaining metabolic health with poor health being linked to 'gu...

journal_title：Future microbiology

authors： Tran CD,Grice DM,Wade B,Kerr CA,Bauer DC,Li D,Hannan GN

更新日期：2015-01-01 00:00:00

abstract：:The aggregate of microorganisms residing on the surface of the skin, in the oropharynx and in the GI tract, known as the human microbiota, play a major role as natural reservoirs for bacterial resistance to antibiotics. Fluoroquinolones (FQ) are among the most prescribed antibiotics and a major increase in FQ resistan...

journal_title：Future microbiology

authors： de Lastours V,Fantin B

更新日期：2015-01-01 00:00:00

abstract：:Aim:Cryptococcus neoformans is the major agent of cryptococcosis. The main virulence factor is the polysaccharide (PS) capsule. Changes in cryptococcal PS properties have been poorly elucidated. Materials & methods: We analyzed the mechanical properties of secreted PS and intact capsules, using dynamic light scatterin...

journal_title：Future microbiology

authors： de S Araújo GR,Viana NB,Pontes B,Frases S

更新日期：2019-07-01 00:00:00

abstract：:Aim: To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aur...

journal_title：Future microbiology

authors： Ramírez-Rueda RY,Marinho J,Salvador MJ

更新日期：2019-09-01 00:00:00

abstract：:Background: A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of Mycobacterium tuberculosis. Results: We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward M. tuberculosis H37Rv and isoni...

journal_title：Future microbiology

authors： Volynets GP,Tukalo MA,Bdzhola VG,Derkach NM,Gumeniuk MI,Tarnavskiy SS,Yarmoluk SM

更新日期：2020-07-01 00:00:00