Ceramide: a new lipid "second messenger"?

Abstract:

:1-Alpha, 25-dihydroxyvitamin D3, tumor necrosis factor alpha, and gamma-interferon induce sphingomyelin turnover to ceramide in HL-60 cells. The time frame of the turnover is consistent with ceramide formation being a mediator of growth and differentiation; furthermore, differentiation can be induced by addition of exogenous ceramides alone. Hence, the action of the biologically active form of vitamin D and other nutritionally relevant factors may be mediated by lipid second messenger pathways involving sphingolipids.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Merrill AH

doi

10.1111/j.1753-4887.1992.tb01273.x

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

78-80

issue

3

eissn

0029-6643

issn

1753-4887

journal_volume

50

pub_type

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