Abstract:
:There has been significant public debate about the susceptibility of research to biases of various kinds. The dialogue has extended to the peer-reviewed literature, scientific conferences, the mass media, government advisory bodies, and beyond. While biases can come from myriad sources, the overwhelming focus of the discussion, to date, has been on industry-funded science. Given the critical role that industry has played and will continue to play in the research process, the International Life Sciences Institute (ILSI) North America Working Group on Guiding Principles has, in this paper, set out proposed conflict-of-interest guidelines, regarding industry funding, for protecting the integrity and credibility of the scientific record, particularly with respect to health, nutrition, and food-safety science. Eight principles are enumerated, specifying ground rules for industry-sponsored research. The paper, which issues a challenge to the broader scientific community to address all bias issues, is only a first step; the document is intended to be dynamic, prompting ongoing discussion and refinement. The Guiding Principles are as follows. In the conduct of public/private research relationships, all relevant parties shall: 1) conduct or sponsor research that is factual, transparent, and designed objectively; according to accepted principles of scientific inquiry, the research design will generate an appropriately phrased hypothesis and the research will answer the appropriate questions, rather than favor a particular outcome; 2) require control of both study design and research itself to remain with scientific investigators; 3) not offer or accept remuneration geared to the outcome of a research project; 4) prior to the commencement of studies, ensure that there is a written agreement that the investigative team has the freedom and obligation to attempt to publish the findings within some specified time-frame; 5) require, in publications and conference presentations, full signed disclosure of all financial interests; 6) not participate in undisclosed paid authorship arrangements in industry-sponsored publications or presentations; 7) guarantee accessibility to all data and control of statistical analysis by investigators and appropriate auditors/reviewers; and 8) require that academic researchers, when they work in contract research organizations (CRO) or act as contract researchers, make clear statements of their affiliation; require that such researchers publish only under the auspices of the CRO.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Rowe S,Alexander N,Clydesdale F,Applebaum R,Atkinson S,Black R,Dwyer J,Hentges E,Higley N,Lefevre M,Lupton J,Miller S,Tancredi D,Weaver C,Woteki C,Wedral E,International Life Sciences Institute (ILSI) North America Workindoi
10.1111/j.1753-4887.2009.00188.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
264-72issue
5eissn
0029-6643issn
1753-4887pii
NURE188journal_volume
67pub_type
杂志文章,评审abstract::On April 7-8, 2014, the European Hydration Institute hosted a small group of experts at Castle Combe Manor House, United Kingdom, to discuss a range of issues related to human hydration, health, and performance. The meeting included 18 recognized experts who brought a wealth of experience and knowledge to the topics u...
journal_title:Nutrition reviews
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doi:10.1093/nutrit/nuv056
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abstract::Several studies have indicated that omega-3 poly-unsaturated fatty acids in fish oil have protective effects on cardiovascular disease by reducing vascular endothelial inflammation in atherosclerosis. In a recent study, supplementation of patients with fish oil following coronary angioplasty elevated levels of lipid p...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2000.tb07812.x
更新日期:2000-02-01 00:00:00
abstract::Despite a general lack of evidence for the carcinogenic effects of trans fatty acids, some recent research and popular media have suggested a possible association. The available scientific data do not support this relationship and are reviewed so as to put this issue in perspective. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1996.tb03916.x
更新日期:1996-05-01 00:00:00
abstract::Genistein is a soy-derived biologically active isoflavone that exhibits diverse health-promoting effects. An increasing body of evidence shows that genistein influences lipid homeostasis and insulin resistance, counteracts inflammatory cytokines, and possesses antidiabetic properties. Genistein also impedes cancer pro...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12044
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abstract::In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural iso...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00213.x
更新日期:2009-07-01 00:00:00
abstract::The lipoprotein lipase gene is highly polymorphic, and several common mutations have been associated with an increased atherogenic lipid profile. One of these, Asn291Ser, was also found to be associated with increased ischemic heart disease in women. More recently, this same mutation, present in approximately 5% of th...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2000.tb01826.x
更新日期:2000-10-01 00:00:00
abstract::We present a case of the eosinophilia-myalgia syndrome in a patient taking large doses of L-tryptophan for sedation. He developed the now-classic findings of myalgias, skin changes, and marked eosinophilia. This syndrome was first recognized in late 1989, and epidemiologic studies have demonstrated an association of t...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1990.tb02969.x
更新日期:1990-08-01 00:00:00
abstract::Lipid oxidation products are present in unknown amounts in the food supply of industrialized societies. Evidence for a putative role of some of these compounds in accelerating events in the atherogenic process--the initiation of endothelial injury, the accumulation of plaque, and the termination phase of thrombosis--c...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1993.tb03064.x
更新日期:1993-02-01 00:00:00
abstract::Maternal vitamin B6 status correlates birth weight with infant behavior and maternal infant interactions. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1991.tb07375.x
更新日期:1991-10-01 00:00:00
abstract::The identity of the protein responsible for hemochromatosis, the iron overload disease, has eluded scientists for years. However, a recent report identifies the gene where the hemochromatosis defect lies. It is a gene that encodes a major histocompatibility complex (MHC) class-1-like protein called HLA-H. The mechanis...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1996.tb03949.x
更新日期:1996-09-01 00:00:00
abstract::The essential fatty acids (EFAs), particularly the n-3 long-chain polyunsaturated fatty acids (LCPs), are important for brain development during both the fetal and postnatal period. They are also increasingly seen to be of value in limiting the cognitive decline during aging. EFA deficiency was first shown over 75 yea...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/nr.2006.may.s24-s33
更新日期:2006-05-01 00:00:00
abstract::Combining data from two large-scale prospective observational studies in women and men, investigators link the consumption of fruits and vegetables to the risk of ischemic stroke. Of interest is their breakdown of these foods into cruciferous vegetables and citrus fruit juice, which confer the greatest protection. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2001.tb01902.x
更新日期:2001-01-01 00:00:00
abstract::In recent years it has been suggested that patients with celiac disease can be adequately followed up on the basis of merely clinical and serological response to a gluten-free diet. Thus, a duodenal biopsy some months after commencement of a gluten-free diet would no longer be necessary. We report here the case of a c...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2004.tb00062.x
更新日期:2004-09-01 00:00:00
abstract::The Metabolic Syndrome, also known as Syndrome X, refers to a constellation of atherosclerotic risk factors, including insulin resistance, hyperinsulinemia, dyslipidemia, essential hypertension, and abdominal obesity. We review four major published studies involving animals and humans that may be linked together in a ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/002966402320583398
更新日期:2002-10-01 00:00:00
abstract::Dietary fat facilitates the utilization of carotenoids and, based on serum beta-carotene or retinol responses following ingestion of meals containing carotene and fat sources, it has been reported that the amount of fat required in a meal may be minimal (approximately 3-5 g). However, the dietary fat requirement for o...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/00296640260085831
更新日期:2002-04-01 00:00:00
abstract::Sarcopenia is the degenerative loss of skeletal muscle that occurs naturally in individuals as they age. Although many factors underlie sarcopenia, epidemiological and experimental evidence suggests that low-grade chronic inflammation is an important contributor to its progression. Still, few healthcare professionals ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2007.tb00364.x
更新日期:2007-12-01 00:00:00
abstract::The human body is an ecosystem harboring complex site-specific microbial communities. The majority of these human-associated microbes are found in the intestinal tract, where they play important roles in energy uptake, vitamin synthesis, and epithelial and immunity development. Recent molecular studies have characteri...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00237.x
更新日期:2009-11-01 00:00:00
abstract::The complementary feeding period, when solids and liquids other than breast milk and formula are added to the infant diet, is an important development window shaping infant growth and weight gain, metabolic development, and lifelong eating practices. Yet, relatively little is known about how the timing and types of fo...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuz057
更新日期:2020-12-01 00:00:00
abstract::A recent study on lactose intolerance and irritable bowel syndrome has shown that subjective lactose intolerance is increased in patients with irritable bowel syndrome, despite no increase in the prevalence of lactose maldigestion. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1998.tb01665.x
更新日期:1998-10-01 00:00:00
abstract::The Institute of Medicine reported in 2005 that food and beverage marketing to children and youth is "out of balance with healthful diets". The dominant policy response in the United States has been to encourage self-regulation by the food, beverage, advertising, and media industries. From a nutrition perspective, thi...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00183.x
更新日期:2009-03-01 00:00:00
abstract::Policy and programmatic change in the food retail setting, including excise taxes on beverages with added-caloric sweeteners, new supermarkets in food deserts, and voluntary corporate pledges, often require the use of natural experimental evaluation for impact evaluation when randomized controlled trials are not possi...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1093/nutrit/nux051
更新日期:2017-12-01 00:00:00
abstract::As health care cost analysts and administrators look for ways to maximize reimbursement revenues and lower operating costs without compromising the quality of patient care, reductions in nutrition services are often targeted. However, improved or expanded nutrition services can actually help cut hospital costs or incr...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1996.tb03885.x
更新日期:1996-04-01 00:00:00
abstract::Current US guidelines for cholesterol recommend limiting intake of cholesterol to <300 mg/day for the general population and <200 mg/day for individuals with elevated low-density lipoprotein cholesterol. These recommendations, however, are at odds with international (e.g., Canada, United Kingdom, and Australia) guidel...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2010.00294.x
更新日期:2010-06-01 00:00:00
abstract::The dietary reference intakes (DRIs) are a set of reference intake levels for nutrients that can be used for planning diets and assessing nutrient inadequacies of individuals and groups. Since the publication of the DRI reports 1997-2004, the reference intake levels have been used for various purposes. While DRIs have...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12067
更新日期:2013-10-01 00:00:00
abstract::Attaining peak skeletal bone mass during childhood may reduce the incidence of osteoporosis in later life. A recent study in six- to 14-year-old identical twins showed that calcium supplementation increased bone mineral density. The effects of supplementation were especially pronounced in prepubertal children. ...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1992.tb07721.x
更新日期:1992-11-01 00:00:00
abstract::A recent study indicates that lowering homocysteine with folic acid and vitamin B6 significantly reduces the incidence of abnormal exercise electrocardiography tests and thus decreases the risk of atherosclerotic disease. Questions about study design and sample size, however, suggest that this conclusion may be premat...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2001.tb07016.x
更新日期:2001-07-01 00:00:00
abstract::This paper examines the speed of change in diet, activity, and obesity in the developing world, and notes potential exacerbating biological relationships that contribute to differences in the rates of change. The focus is on lower- and middle-income countries of Asia, Africa, the Middle East, and Latin America. These ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2004.tb00084.x
更新日期:2004-07-01 00:00:00
abstract::Plant-based diets, and more specifically plant-based proteins, have been the subject of growing interest from researchers and consumers because of their potential health benefits as well as their positive environmental impact. Of course, plant proteins are found in plant foods, and positive health benefits of plant fo...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1093/nutrit/nuz028
更新日期:2019-11-01 00:00:00
abstract::Type 2 diabetic patients are at high risk of bone fractures even if their bone mineral density is normal or high. This is likely explained by poor bone quality and extraskeletal factors. The present review was conducted to provide an overview of the currently available preclinical and clinical evidence on the effect o...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2011.00380.x
更新日期:2011-03-01 00:00:00
abstract::Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in humans, but they are not generally consumed at levels that effect significant change in biomarkers of health. Because consumers have embraced the notion that dietary supplements may prevent disease, this review considers whether an a...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12060
更新日期:2013-11-01 00:00:00