Abstract:
:Type 2 diabetic patients are at high risk of bone fractures even if their bone mineral density is normal or high. This is likely explained by poor bone quality and extraskeletal factors. The present review was conducted to provide an overview of the currently available preclinical and clinical evidence on the effect of vitamin K(2) on bone quality in persons with type 2 diabetes. Vitamin K(2) stimulates γ-carboxylation of osteocalcin and can increase bone formation through steroid and xenobiotic receptors. Clinical studies of type 2 diabetic patients have shown detrimental collagen cross-links in bone; low serum insulin-like growth factor-I and osteocalcin concentration are associated with an increased risk of fractures. A therapeutic strategy for preventing fractures in type 2 diabetic patients remains to be established. One recent preclinical study showed that vitamin K(2) administration in a type 2 diabetic rat model had the following skeletal benefits: increased serum osteocalcin, improved collagen cross-link profiles, and increased bone strength. These new findings suggesting a possible beneficial effect of vitamin K(2) supplementation on bone quality in type 2 diabetes warrant further investigation.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Iwamoto J,Sato Y,Takeda T,Matsumoto Hdoi
10.1111/j.1753-4887.2011.00380.xsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
162-7issue
3eissn
0029-6643issn
1753-4887journal_volume
69pub_type
杂志文章,评审abstract::This review shows how some transcription factors respond to alterations in macronutrients. Carbohydrates induce enzymes for their metabolism and fatty acid synthesis. Fatty acids reduce carbohydrate processing, induce enzymes for their metabolism, and increase both gluconeogenesis and storage of fat. Fat stores help c...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2008.00039.x
更新日期:2008-06-01 00:00:00
abstract::Twenty publications from twelve prospective cohorts have evaluated associations between flavonoid intakes and incidence or mortality from cardiovascular disease (CVD) among adults in Europe and the United States. The most common outcome was coronary heart disease mortality, and four of eight cohort studies reported si...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2012.00508.x
更新日期:2012-09-01 00:00:00
abstract::In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural iso...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00213.x
更新日期:2009-07-01 00:00:00
abstract::Parkinson's disease (PD) is the second most common aging-related disorder in the world, after Alzheimer's disease. It is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and other parts of the brain, leading to motor impairment, cognitive impairment, and dementia. Cur...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2012.00484.x
更新日期:2012-07-01 00:00:00
abstract::Mammalian cells use an exquisitely sensitive mechanism to control the amount of cholesterol and fatty acids in their membranes. This process relies on a feedback system that adjusts the rates of transcription of genes encoding the low density lipoprotein receptor and multiple enzymes in the cholesterol and fatty acid ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1998.tb01680.x
更新日期:1998-02-01 00:00:00
abstract::Copper transport at the cellular level is achieved by a coordinate series of interactions between passive and active membrane transport proteins, vesicles, and soluble peptides. Knowing the function of each component of this complex network has made the task of delineating the mechanism of intracellular copper homeost...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2001.tb07017.x
更新日期:2001-09-01 00:00:00
abstract::Meta-analyses on 6 of 12 studies of the effect of improvement of the vitamin A status of deficient children living in poverty and social and biological deprivation conclude that mortality reduction can be expected. The demonstrated effects on incidence, prevalence and severity of specific morbidities under these condi...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1994.tb01407.x
更新日期:1994-04-01 00:00:00
abstract:Context:Obesity, type 2 diabetes, and dental caries are all major public health problems in the United Kingdom and contribute substantially to healthcare costs. Objective:A systematic review and meta-analysis was conducted to determine the effect of product reformulation measures on sugar intake and health outcomes. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,meta分析
doi:10.1093/nutrit/nuy015
更新日期:2019-03-01 00:00:00
abstract::Risks for gastric cancer in relation to diet and other environmental factors are receiving renewed attention. New developments include the emerging relationship between Helicobacter pylori infection and an increased risk for gastric cancer, and positive results of chemoprevention trials in decreasing gastric cancer ri...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1994.tb01394.x
更新日期:1994-03-01 00:00:00
abstract::Despite forty years of research on the potential role of chromium in carbohydrate and lipid metabolism, significant progress has only recently been made regarding the mode of action of chromium at a molecular level. The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a nove...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2000.tb01841.x
更新日期:2000-03-01 00:00:00
abstract::Dietary reference intakes (DRIs) for vitamin C for healthy U.S. populations are currently being formulated by the Panel on Dietary Antioxidants and Related Compounds of the Food and Nutrition Board of the Institute of Medicine. A major task of the Panel is to analyze the evidence of adverse effects of high-dose vitami...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1999.tb06926.x
更新日期:1999-03-01 00:00:00
abstract::Attaining peak skeletal bone mass during childhood may reduce the incidence of osteoporosis in later life. A recent study in six- to 14-year-old identical twins showed that calcium supplementation increased bone mineral density. The effects of supplementation were especially pronounced in prepubertal children. ...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1992.tb07721.x
更新日期:1992-11-01 00:00:00
abstract:CONTEXT:Contrary to nutritional guidelines, accumulating evidence shows that pregnant women's energy intakes remain stable throughout trimesters. Although pregnant women may eat below their needs or underreport their energy intakes, it is also relevant to question how energy requirements - estimated through measurement...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuaa093
更新日期:2020-09-25 00:00:00
abstract::Based on the fact that energy content in 1 gram of alcohol is 29 kJ or 7.1 kcal, alcohol consumption can lead to weight gain. The present review was conducted to analyze the effects of alcohol consumption on body weight. A search of the Medline database for the period 1984 to March 2010 was conducted to identify cross...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2011.00403.x
更新日期:2011-08-01 00:00:00
abstract::Although low-income youth are likely to have low or less frequent fruit and vegetable intake, current understanding of the influences on intake in youth is limited. A systematic review of quantitative research on determinants of fruit and vegetable intake among low-income youth (i.e., persons aged <20 years) was condu...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12126
更新日期:2014-09-01 00:00:00
abstract::Both essential and nonessential dietary antioxidants have been suggested to be beneficial for health. However, studies show that many antioxidants can also exhibit prooxidant behavior under certain conditions. The antioxidant/prooxidant activity of phenolics is dependent on such factors as metal-reducing potential, ch...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1997.tb01580.x
更新日期:1997-11-01 00:00:00
abstract::The burden of maternal morbidity and mortality in developing countries is high. Each year, 600,000 women die from pregnancy-related causes and 62 million women suffer from morbidity and complications of pregnancy. The extent to which maternal nutrition can improve maternal health and survival is not well understood. E...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/00296640260130759
更新日期:2002-05-01 00:00:00
abstract::The declining diversity of agricultural production and food supplies worldwide may have important implications for global diets. The primary objective of this review is to assess the nature and magnitude of the associations of agricultural biodiversity with diet quality and anthropometric outcomes in low- and middle-i...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1093/nutrit/nux040
更新日期:2017-10-01 00:00:00
abstract::Food fortification is an important strategy to combat iron and zinc deficiency. This review covers the basic concepts of food fortification, as well as its advantages and disadvantages. The main characteristics of the most common zinc and iron compounds used in this procedure are also analyzed. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/00296640260085958
更新日期:2002-02-01 00:00:00
abstract::Continually expanding evidence has moved inexorably toward establishing key functions for cellular retinol-binding protein (CRBP) in retinoid metabolism. These experimental data integrate into a model of CRBP as a chaperone that protects retinol from the cellular milieu and interacts with certain retinoid-metabolizing...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2000.tb01870.x
更新日期:2000-08-01 00:00:00
abstract::Restriction of copper intake during lactation and postlactation periods reduced T cells and increased interleukin-2 receptors in isolated splenocytes from male, but not female, rats. However, a reduced in vitro proliferative response to phytohemagglutin (PHA) was seen in both male and female Cu-deficient rats. These f...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1992.tb01300.x
更新日期:1992-04-01 00:00:00
abstract::Although body weight is considered to positively affect bones of children and adults, recent studies suggest that overweight and obesity in childhood and adolescence reduce bone mineral content below what would be predicted based on weight and are associated with an increase in incidence of childhood fractures. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/002966402760240327
更新日期:2002-01-01 00:00:00
abstract::A food intake pattern specifying amounts and types of food was created for Canada's revised food guide, Eating Well with Canada's Food Guide (2007), using a two-step modeling process. In step one, food composites were manipulated to develop a food intake pattern. The second step used the step one food intake pattern t...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2007.tb00295.x
更新日期:2007-04-01 00:00:00
abstract::The increasing prevalence of overweight and obesity highlight the need for improved intervention strategies to counteract this significant public health problem. To this end, it appears that increases in energy expenditure through exercise and other forms of physical activity may be an important component of effective...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2006.tb00235.x
更新日期:2006-02-01 00:00:00
abstract::Dietary fat facilitates the utilization of carotenoids and, based on serum beta-carotene or retinol responses following ingestion of meals containing carotene and fat sources, it has been reported that the amount of fat required in a meal may be minimal (approximately 3-5 g). However, the dietary fat requirement for o...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/00296640260085831
更新日期:2002-04-01 00:00:00
abstract::Mitochondrial disorders (MDs) are caused by impairment of the mitochondrial electron transport chain (ETC). The ETC is needed for oxidative phosphorylation, which provides the cell with the most efficient energy outcome in terms of ATP production. One of the pathogenic mechanisms of MDs is the accumulation of reactive...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00221.x
更新日期:2009-08-01 00:00:00
abstract::Children one to ten years of age who had had the fetal alcohol syndrome were compared with age-matched children with intrauterine growth retardation without exposure to alcohol. Those with fetal alcohol syndrome had greater impairment of immune function. ...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1982.tb05259.x
更新日期:1982-02-01 00:00:00
abstract:CONTEXT:The ability to measure the gut microbiome led to a surge in understanding and knowledge of its role in health and disease. The diet is a source of fuel for and influencer of composition of the microbiome. OBJECTIVE:To assess the understanding of the interactions between nutrition and the gut microbiome in heal...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuz106
更新日期:2020-10-01 00:00:00
abstract::Urinary excretion of 3-methyl histidine was found to be reduced in starvation. Data show that the rate of muscle catabolism is reduced to a greater extent than muscle mass. Reutilization of amino acids appears not to be greatly enhanced during starvation. ...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1974.tb00962.x
更新日期:1974-07-01 00:00:00
abstract::Vascular defects associated with dietary copper deficiency may result from altered interactions between vascular smooth muscle cells and nitric oxide. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1993.tb03101.x
更新日期:1993-06-01 00:00:00