Abstract：
:Parkinson's disease (PD) is the second most common aging-related disorder in the world, after Alzheimer's disease. It is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and other parts of the brain, leading to motor impairment, cognitive impairment, and dementia. Current treatment methods, such as L-dopa therapy, are focused only on relieving symptoms and delaying progression of the disease. To date, there is no known cure for PD, making prevention of PD as important as ever. More than a decade of research has revealed a number of major risk factors, including oxidative stress and mitochondrial dysfunction. Moreover, numerous nutraceuticals have been found to target and attenuate these risk factors, thereby preventing or delaying the progression of PD. These nutraceuticals include vitamins C, D, E, coenzyme Q10, creatine, unsaturated fatty acids, sulfur-containing compounds, polyphenols, stilbenes, and phytoestrogens. This review examines the role of nutraceuticals in the prevention or delay of PD as well as the mechanisms of action of nutraceuticals and their potential applications as therapeutic agents, either alone or in combination with current treatment methods.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Chao J,Leung Y,Wang M,Chang RCdoi
10.1111/j.1753-4887.2012.00484.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
373-86issue
7eissn
0029-6643issn
1753-4887journal_volume
70pub_type
杂志文章,评审abstract：Context:In recent decades, portion sizes have increased significantly. Although previous research indicates that food labels impact on product choice and healthiness perception, their impact on portion sizes consumed is less clear. Objective:This systematic review examined whether food label information influenced por...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuy019
更新日期：2018-09-01 00:00:00
abstract：:Proanthocyanidins are a major group of flavonoids in the human diet, known for their strong antioxidant properties. Emerging evidence from clinical studies indicates a role of proanthocyanidins in modulating glucose homeostasis, and higher proanthocyanidin intake has been associated with reduced risk of diabetes. On t...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nux028
更新日期：2017-08-01 00:00:00
abstract：:This article reviews the environmental impact of genetically modified crops through discussion of environmental risk assessment and includes several case studies. Influence of European regulatory and political issues is considered. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.jun.S105-S109
更新日期：2003-06-01 00:00:00
abstract：:The sequence of repair of fat deficiency symptoms depends on whether linoleate or arachidonate is used in treatment, although both methods lead to an increase in arachidonate. Arachidonate is less rapidly oxidized and more rapidly incorporated into phospholipid. ...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1966.tb08384.x
更新日期：1966-04-01 00:00:00
abstract：:Attention to the different types of carbohydrates and their role in health and disease is relatively recent. FAO and WHO jointly published a report on carbohydrates in human nutrition in 1998, with a number of recommendations about increasing carbohydrate intake as a sound approach to the prevention of obesity. The gl...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.may.S34-S39
更新日期：2003-05-01 00:00:00
abstract：:Plant-based diets, and more specifically plant-based proteins, have been the subject of growing interest from researchers and consumers because of their potential health benefits as well as their positive environmental impact. Of course, plant proteins are found in plant foods, and positive health benefits of plant fo...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuz028
更新日期：2019-11-01 00:00:00
abstract：:Risks for gastric cancer in relation to diet and other environmental factors are receiving renewed attention. New developments include the emerging relationship between Helicobacter pylori infection and an increased risk for gastric cancer, and positive results of chemoprevention trials in decreasing gastric cancer ri...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1994.tb01394.x
更新日期：1994-03-01 00:00:00
abstract：:Magnesium deficiency is prevalent in women of childbearing age in both developing and developed countries. The need for magnesium increases during pregnancy, and the majority of pregnant women likely do not meet this increased need. Magnesium deficiency or insufficiency during pregnancy may pose a health risk for both...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuw018
更新日期：2016-09-01 00:00:00
abstract：:Convincing epidemiologic evidence currently exists for an association between physical activity and the prevention of colon and breast cancer Physical activity may also reduce the risk of cancer at several other sites. With increasing research on this topic, it is apparent that studies of physical activity and cancer ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2001.tb06962.x
更新日期：2001-11-01 00:00:00
abstract：:The Institute of Medicine reported in 2005 that food and beverage marketing to children and youth is "out of balance with healthful diets". The dominant policy response in the United States has been to encourage self-regulation by the food, beverage, advertising, and media industries. From a nutrition perspective, thi...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00183.x
更新日期：2009-03-01 00:00:00
abstract：CONTEXT:Contrary to nutritional guidelines, accumulating evidence shows that pregnant women's energy intakes remain stable throughout trimesters. Although pregnant women may eat below their needs or underreport their energy intakes, it is also relevant to question how energy requirements - estimated through measurement...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuaa093
更新日期：2020-09-25 00:00:00
abstract：CONTEXT:The impact of dietary protein on body composition changes after older adults purposefully lose weight requires systematic evaluation OBJECTIVE:: This systematic review and meta-analysis assessed the effects of protein intake (< 25% vs ≥ 25% of energy intake or 1.0 g/kg/d) on energy restriction-induced changes ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuv065
更新日期：2016-03-01 00:00:00
abstract：:Healthy humans regulate daily water balance remarkably well across their lifespan despite changes in biological development and exposure to stressors on hydration status. Acute or chronic body water deficits result when intakes are reduced or losses increase, but day-to-day hydration is generally well maintained so lo...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2005.tb00152.x
更新日期：2005-06-01 00:00:00
abstract：:The increasing prevalence of overweight and obesity highlight the need for improved intervention strategies to counteract this significant public health problem. To this end, it appears that increases in energy expenditure through exercise and other forms of physical activity may be an important component of effective...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2006.tb00235.x
更新日期：2006-02-01 00:00:00
abstract：:Under conditions of energy balance, energy intake (EI) equals energy expenditure (EE), and the validity of EI may be determined by comparing these two measures. The doubly labeled water (DLW) method is the gold standard for the determination of EE. Its use in developed countries has showed an intense underreporting of...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2006.jul.319-330
更新日期：2006-07-01 00:00:00
abstract：:Twenty publications from twelve prospective cohorts have evaluated associations between flavonoid intakes and incidence or mortality from cardiovascular disease (CVD) among adults in Europe and the United States. The most common outcome was coronary heart disease mortality, and four of eight cohort studies reported si...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2012.00508.x
更新日期：2012-09-01 00:00:00
abstract：:Innovative approaches are needed to impact obesity and other diet-related chronic diseases, including interventions at the environmental and policy levels. Such interventions are promising due to their wide reach. This article reports on 10 multilevel community trials that the present authors either led (n = 8) or pla...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuw038
更新日期：2017-01-01 00:00:00
abstract：:Consumption of highly processed foods, such as those high in trans fats and free sugars, coupled with sedentarism and chronic stress increases the risk of obesity and cardiometabolic disorders, while adherence to a Mediterranean diet is inversely associated with the prevalence of such diseases. Olive oil is the main s...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuaa014
更新日期：2020-11-01 00:00:00
abstract：:Epidemiologic studies have demonstrated an increased incidence of kidney stones in individuals with low calcium intake. More recently, a 5-year clinical study found the recurrence of kidney stones was higher in stone-formers on a low dietary calcium treatment. Considering these important new findings, and the known ad...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/00296640260184291
更新日期：2002-07-01 00:00:00
abstract：:Dietary management has been considered an alternative means of modulating adiponectin levels. The purpose of this review is to examine the scientific evidence regarding the effect of diet on adiponectin levels in blood. Clinical trials were selected from Medline until April 2010 using the following MeSH terms: adipoki...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00414.x
更新日期：2011-10-01 00:00:00
abstract：:Recent data on the expression and function of the ZIP family of proteins has suggested that these zinc transporters may be useful biomarkers for the diagnosis and prognosis of human breast cancer. This exciting new area of research opens the door for the use of a variety of nutritionally regulated genes and proteins a...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2008.00020.x
更新日期：2008-03-01 00:00:00
abstract：:Although body weight is considered to positively affect bones of children and adults, recent studies suggest that overweight and obesity in childhood and adolescence reduce bone mineral content below what would be predicted based on weight and are associated with an increase in incidence of childhood fractures. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402760240327
更新日期：2002-01-01 00:00:00
abstract：:The lipoprotein lipase gene is highly polymorphic, and several common mutations have been associated with an increased atherogenic lipid profile. One of these, Asn291Ser, was also found to be associated with increased ischemic heart disease in women. More recently, this same mutation, present in approximately 5% of th...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2000.tb01826.x
更新日期：2000-10-01 00:00:00
abstract：CONTEXT:The association between dairy product intake and the risk of developing type 2 diabetes (T2D) or cardiovascular disease (CVD) has been investigated in several studies, but little attention was given to the role of sex as a moderator of these associations. (In this article, the term "sex" is used to denote the b...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuz006
更新日期：2019-06-01 00:00:00
abstract：:There is much (renewed) interest about the effects of salicylates on food intolerance, attention-deficit disorders, and cardiovascular disease. Current evidence for the efficacy of salicylate-elimination diets in the treatment of attention-deficit disorders and hyperactivity is weak, and further investigation is requi...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1996.tb03940.x
更新日期：1996-08-01 00:00:00
abstract：Context:Dairy intake in humans is commonly assessed using questionnaires, but the data collected are often biased. As a result, there is increasing interest in biomarkers of dairy fat. To date, there has been no overview of the fatty acids suitable for use as biomarkers of dairy fat intake. Objective:This systematic r...
journal_title：Nutrition reviews
pub_type： 杂志文章,meta分析
doi：10.1093/nutrit/nuy048
更新日期：2019-01-01 00:00:00
abstract：:Disagreement about the use of animals in biomedical research has resulted in absurd positions by both sides. Increasingly, some zealots against animal experimentation have resorted to violence or other illegal acts to support their points of view. The value of animal research in providing better health for man and ani...
journal_title：Nutrition reviews
pub_type： 历史文章,杂志文章
doi：10.1111/j.1753-4887.2008.00144.x
更新日期：2009-02-01 00:00:00
abstract：:Several studies have indicated that omega-3 poly-unsaturated fatty acids in fish oil have protective effects on cardiovascular disease by reducing vascular endothelial inflammation in atherosclerosis. In a recent study, supplementation of patients with fish oil following coronary angioplasty elevated levels of lipid p...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2000.tb07812.x
更新日期：2000-02-01 00:00:00
abstract：:Two recent studies suggest that when consuming a low-calcium diet, low efficiency of calcium absorption (measured as fractional calcium absorption) is a problem in the elderly; this is also an important risk factor for hip fracture. These studies show that elderly women are less able to compensate for low calcium inta...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2001.tb06959.x
更新日期：2001-10-01 00:00:00
abstract：:Based on the fact that energy content in 1 gram of alcohol is 29 kJ or 7.1 kcal, alcohol consumption can lead to weight gain. The present review was conducted to analyze the effects of alcohol consumption on body weight. A search of the Medline database for the period 1984 to March 2010 was conducted to identify cross...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00403.x
更新日期：2011-08-01 00:00:00
