Quest for the molecular mechanism of chromium action and its relationship to diabetes.

Abstract:

:Despite forty years of research on the potential role of chromium in carbohydrate and lipid metabolism, significant progress has only recently been made regarding the mode of action of chromium at a molecular level. The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a novel insulin-signaling autoamplification mechanism. The proposed mechanism of action also sheds some light on the potential of chromium-containing compounds as nutritional supplements or in the treatment of adult-onset diabetes and other conditions. The potential relationship between the results of recent studies on diabetic patients and the proposed mode of action of LMWCr are discussed.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Vincent JB

doi

10.1111/j.1753-4887.2000.tb01841.x

keywords:

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

67-72

issue

3 Pt 1

eissn

0029-6643

issn

1753-4887

journal_volume

58

pub_type

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