Abstract：
:From late 1991 to mid-1993, cases of optic neuropathy of unknown etiology, which first appeared in unusual numbers in a western province of Cuba, spread and multiplied throughout the island. The dominant symptoms changed, becoming increasingly those of peripheral neuropathy. Incidence rates peaked in April 1993. An estimated 50,000 cases were reported. The majority were adult men and women (aged about 25-65), with comparatively few children or elderly people being affected. The cause has yet to be delineated. However, food shortages and radical changes in diet resulting from the longstanding US trade embargo and the recent loss of Eastern Europe as Cuba's trading partner have compromised nutritional status, especially B-vitamin sufficiency, and appear to be related to the neuropathic illnesses. In April 1993, the Cuban government began distributing vitamin supplements to every citizen. Causal hypotheses include tobacco-alcohol or "nutritional" amblyopia; cyanide toxicity from cassava; toxic legumes introduced as supplements to scarce flour; other toxins, for example pesticides, or a "blue mold" on tobacco; enterovirus; and a hereditary enzyme deficiency in affected persons. None of these factors appears to be present in all cases, but it is generally believed that an interaction of some toxin or toxins, in combination with nutritional deficiency, is likely to be the major cause.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Tucker K,Hedges TRdoi
10.1111/j.1753-4887.1993.tb03766.xsubject
Has Abstractpub_date
1993-12-01 00:00:00pages
349-57issue
12eissn
0029-6643issn
1753-4887journal_volume
51pub_type
杂志文章,评审abstract：:The incidence of multifetal pregnancies has increased, mainly because of assisted reproduction treatments. This trend is reflected in increased maternal and neonatal morbidity and mortality. While the optimum maternal nutrition and weight gain patterns for singleton pregnancies is well documented, there is a paucity o...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2005.tb00144.x
更新日期：2005-09-01 00:00:00
abstract：:Perchlorate inhibits the uptake of iodide into the thyroid gland, thereby possibly affecting the synthesis of thyroid hormones. Pregnant women and their fetuses and newborns have the greatest potential for risk of adverse health effects following exposure to perchlorate. Perchlorate is present in some foods and in dri...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00260.x
更新日期：2010-01-01 00:00:00
abstract：:The declining diversity of agricultural production and food supplies worldwide may have important implications for global diets. The primary objective of this review is to assess the nature and magnitude of the associations of agricultural biodiversity with diet quality and anthropometric outcomes in low- and middle-i...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nux040
更新日期：2017-10-01 00:00:00
abstract：:Although body weight is considered to positively affect bones of children and adults, recent studies suggest that overweight and obesity in childhood and adolescence reduce bone mineral content below what would be predicted based on weight and are associated with an increase in incidence of childhood fractures. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402760240327
更新日期：2002-01-01 00:00:00
abstract：:Choline is involved in methyl group metabolism and lipid transport and is a component of a number of important biological compounds including the membrane phospholipids lecithin, sphingomyelin, and plasmalogen; the neurotransmitter acetylcholine; and platelet activating factor. Although a required nutrient for several...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1994.tb01357.x
更新日期：1994-10-01 00:00:00
abstract：:Epidemiological studies have suggested an association between vitamin C (and other antioxidant vitamins) and cancer risk. However, the mechanisms accounting for prevention have not been extensively investigated. In skin, vitamin C (ascorbic acid) exerts different biological roles, including photoprotective effects and...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2005.tb00125.x
更新日期：2005-03-01 00:00:00
abstract：:Observational studies have found that diets rich in whole-grain foods are associated with improved insulin sensitivity. The improved insulin sensitivity may be mediated in part by magnesium and dietary fiber, two nutrients found in whole-grain foods. By incorporating whole-grain foods into the diet, therefore, insulin...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2004.tb00054.x
更新日期：2004-07-01 00:00:00
abstract：:This report is the first in a series of publications resulting from the comprehensive effort being undertaken by the Food and Nutrition Board's Committee on the Scientific Evaluation of Dietary Reference Intakes and its panels and subcommittees. The history and rationale behind the development of the Dietary Reference...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1997.tb01623.x
更新日期：1997-09-01 00:00:00
abstract：:Observational studies document a positive relationship between vitamin D from the environment (sunlight or diet), circulating vitamin D status, and improved symptoms or prevention of multiple sclerosis (MS). Experimental animal models of MS reproduce the beneficial effects of vitamin D and 1,25(OH)(2)D(3). The geograp...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2008.00097.x
更新日期：2008-10-01 00:00:00
abstract：:Studying the effects of dehydration on cognitive function presents a variety of unique and difficult challenges to investigators. These challenges, which are addressed in this article, can be divided into three general categories: 1) choosing an appropriate method of generating a consistent level of dehydration; 2) de...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2012.00524.x
更新日期：2012-11-01 00:00:00
abstract：:In order to examine the prevalence of overweight and obesity in childhood within the Indian subcontinent, a meta-analysis of studies was conducted. Within the data sets analyzed, six homogeneous statistical subgroups were observed and three levels of prevalence were discernible (low, intermediate, and high). The poole...
journal_title：Nutrition reviews
pub_type： 杂志文章,meta分析
doi：10.1111/nure.12130
更新日期：2014-08-01 00:00:00
abstract：:The body of knowledge about plants, herbs, and spices and their respective and collective roles in promoting human health is modest. Flavonoids in tea and anthocyanins in tart cherries were presented as examples of how to move forward in understanding active compounds. Dietary compounds, their roles in maintaining hum...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1999.tb01806.x
更新日期：1999-09-01 00:00:00
abstract：CONTEXT:Serotonergic dysfunction, including reduced central serotonin levels, is associated with different psychiatric syndromes, including depression. As a serotonin precursor, 5-hydroxytryptophan has long been used as a nonpharmacological treatment for depression. OBJECTIVE:A systematic review and meta-analysis was ...
journal_title：Nutrition reviews
pub_type： 杂志文章,meta分析
doi：10.1093/nutrit/nuz039
更新日期：2020-01-01 00:00:00
abstract：Context:The metabolism of thyroid hormones, which are essential for normal development, involves many proteins and enzymes. It requires iodine as a key component but is also influenced by several other micronutrients, including selenium, zinc, iron, and vitamin A. Objective:This systematic review was designed to inves...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuy008
更新日期：2018-06-01 00:00:00
abstract：:In a recent case-control study of 164 patients with clinically diagnosed Alzheimer's disease (AD), including 76 patients with the AD diagnosis confirmed postmortem, mean total serum homocysteine concentration was found to be significantly higher than that of a control group of elderly individuals with no evidence of c...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1999.tb06936.x
更新日期：1999-04-01 00:00:00
abstract：:The Institute of Medicine reported in 2005 that food and beverage marketing to children and youth is "out of balance with healthful diets". The dominant policy response in the United States has been to encourage self-regulation by the food, beverage, advertising, and media industries. From a nutrition perspective, thi...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00183.x
更新日期：2009-03-01 00:00:00
abstract：:The Metabolic Syndrome, also known as Syndrome X, refers to a constellation of atherosclerotic risk factors, including insulin resistance, hyperinsulinemia, dyslipidemia, essential hypertension, and abdominal obesity. We review four major published studies involving animals and humans that may be linked together in a ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402320583398
更新日期：2002-10-01 00:00:00
abstract：:In studies of glutathione (GSH) metabolism in children with severe childhood undernutrition (SCU), slower erythrocyte GSH synthesis in children with edema was associated with lower concentrations of cysteine, the rate-limiting precursor of GSH synthesis. This finding suggested a shortage of cysteine available for GSH ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00462.x
更新日期：2012-03-01 00:00:00
abstract：:Plant-based diets, and more specifically plant-based proteins, have been the subject of growing interest from researchers and consumers because of their potential health benefits as well as their positive environmental impact. Of course, plant proteins are found in plant foods, and positive health benefits of plant fo...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuz028
更新日期：2019-11-01 00:00:00
abstract：:A large number of biologically active components have been found in human milk (HM), and in both human and animal models, studies have provided some evidence suggesting that HM composition can be altered by maternal exposures, subsequently influencing health outcomes for the breastfed child. Evidence varies from the r...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuz019
更新日期：2019-05-21 00:00:00
abstract：:Continually expanding evidence has moved inexorably toward establishing key functions for cellular retinol-binding protein (CRBP) in retinoid metabolism. These experimental data integrate into a model of CRBP as a chaperone that protects retinol from the cellular milieu and interacts with certain retinoid-metabolizing...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2000.tb01870.x
更新日期：2000-08-01 00:00:00
abstract：:Meta-analyses on 6 of 12 studies of the effect of improvement of the vitamin A status of deficient children living in poverty and social and biological deprivation conclude that mortality reduction can be expected. The demonstrated effects on incidence, prevalence and severity of specific morbidities under these condi...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1994.tb01407.x
更新日期：1994-04-01 00:00:00
abstract：:Disagreement about the use of animals in biomedical research has resulted in absurd positions by both sides. Increasingly, some zealots against animal experimentation have resorted to violence or other illegal acts to support their points of view. The value of animal research in providing better health for man and ani...
journal_title：Nutrition reviews
pub_type： 历史文章,杂志文章
doi：10.1111/j.1753-4887.2008.00144.x
更新日期：2009-02-01 00:00:00
abstract：:Inflammation is a strong risk factor for cardiovascular disease. Dietary plant sterols are known to reduce plasma cholesterol levels and thereby reduce cardiovascular risk. Recent observations from animal and human studies have demonstrated anti-inflammatory effects of phytosterols. For example, several animal and hum...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00399.x
更新日期：2011-07-01 00:00:00
abstract：:Both essential and nonessential dietary antioxidants have been suggested to be beneficial for health. However, studies show that many antioxidants can also exhibit prooxidant behavior under certain conditions. The antioxidant/prooxidant activity of phenolics is dependent on such factors as metal-reducing potential, ch...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1997.tb01580.x
更新日期：1997-11-01 00:00:00
abstract：:Policy and programmatic change in the food retail setting, including excise taxes on beverages with added-caloric sweeteners, new supermarkets in food deserts, and voluntary corporate pledges, often require the use of natural experimental evaluation for impact evaluation when randomized controlled trials are not possi...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nux051
更新日期：2017-12-01 00:00:00
abstract：:Among the numerous polyphenols isolated from green tea, the catechin EGCG predominates and is the target of anticancer research. But studies suggest that EGCG and other catechins are poorly absorbed and undergo substantial biotransformation to species that include glucuronides, sulfates, and methylated compounds. Nume...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2004.tb00041.x
更新日期：2004-05-01 00:00:00
abstract：:There has been significant public debate about the susceptibility of research to biases of various kinds. The dialogue has extended to the peer-reviewed literature, scientific conferences, the mass media, government advisory bodies, and beyond. While biases can come from myriad sources, the overwhelming focus of the d...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00188.x
更新日期：2009-05-01 00:00:00
abstract：:Anthocyanins are a group of bioactive compounds present in plant foods. Although they have consistently shown an anti-inflammatory effect both in vitro and in vivo, their mechanisms of action are not fully understood and have only recently begun to be elucidated. The aim of this review is to highlight the anti-inflamm...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuu066
更新日期：2015-06-01 00:00:00
abstract：:The burden of maternal morbidity and mortality in developing countries is high. Each year, 600,000 women die from pregnancy-related causes and 62 million women suffer from morbidity and complications of pregnancy. The extent to which maternal nutrition can improve maternal health and survival is not well understood. E...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/00296640260130759
更新日期：2002-05-01 00:00:00
