Small amounts of dietary fructose dramatically increase hepatic glucose uptake through a novel mechanism of glucokinase activation.

Abstract:

:Glucokinase plays a major role in the control of hepatic glucose uptake and storage as glycogen. Small amounts of fructose-1-phosphate, in the presence of relatively high glucose levels, markedly stimulate glucokinase through a novel mechanism of regulation involving dissociation from a regulatory protein and translocation from the nucleus into the cytosol. Using this understanding of glucokinase regulation, a recent study demonstrated that very small amounts of fructose (infused into the duodenum) could increase hepatic glucose uptake and glycogen storage, and reduce peripheral glycemia and insulin levels in the dog. These results suggest that very small amounts of dietary fructose could be beneficial in type 2 diabetes.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Watford M

doi

10.1301/002966402320289377

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

253-7

issue

8

eissn

0029-6643

issn

1753-4887

journal_volume

60

pub_type

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