Abstract:
:Proanthocyanidins are a major group of flavonoids in the human diet, known for their strong antioxidant properties. Emerging evidence from clinical studies indicates a role of proanthocyanidins in modulating glucose homeostasis, and higher proanthocyanidin intake has been associated with reduced risk of diabetes. On the other hand, recent studies report limited bioavailability of proanthocyanidins. At relatively low concentrations in the systemic circulation, proanthocyanidins may act as cell-signaling molecules to modulate glucose homeostasis. For example, they affect hepatic glucose production via adenosine monophosphate-activated protein kinase and/or insulin-signaling pathways. There is also evidence for a direct role of proanthocyanidins in modulating several pancreatic β-cell functions: prevention of oxidative stress, enhancement of insulin secretion, and promotion of β-cell survival. Therefore, greater understanding of the potentially beneficial effects of proanthocyanidins on cell-signaling pathways implicated in glucose homeostasis is needed. In addition, further investigation to address the in vivo metabolism of proanthocyanidins and the comparative effectiveness of proanthocyanidin-derived metabolites is warranted. The dosage and the experimental model should be given special attention when results from mechanistic studies using proanthocyanidins are interpreted.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Yang K,Chan CBdoi
10.1093/nutrit/nux028subject
Has Abstractpub_date
2017-08-01 00:00:00pages
642-657issue
8eissn
0029-6643issn
1753-4887pii
3964515journal_volume
75pub_type
杂志文章abstract::Policy and programmatic change in the food retail setting, including excise taxes on beverages with added-caloric sweeteners, new supermarkets in food deserts, and voluntary corporate pledges, often require the use of natural experimental evaluation for impact evaluation when randomized controlled trials are not possi...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1998.tb01680.x
更新日期:1998-02-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,meta分析
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
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journal_title:Nutrition reviews
pub_type: 杂志文章
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journal_title:Nutrition reviews
pub_type: 杂志文章
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
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journal_title:Nutrition reviews
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pub_type: 杂志文章,评审
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2000.tb01870.x
更新日期:2000-08-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2001.tb05510.x
更新日期:2001-08-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2010.00315.x
更新日期:2010-09-01 00:00:00
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更新日期:2003-06-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
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更新日期:2002-04-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2010.00294.x
更新日期:2010-06-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1990.tb02890.x
更新日期:1990-11-01 00:00:00
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更新日期:2013-10-01 00:00:00
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journal_title:Nutrition reviews
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更新日期:2000-03-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1982.tb05259.x
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1998.tb01665.x
更新日期:1998-10-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/00296640260130876
更新日期:2002-05-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1995.tb05484.x
更新日期:1995-09-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
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更新日期:2005-05-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章,评审
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更新日期:2009-05-01 00:00:00
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journal_title:Nutrition reviews
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doi:10.1111/j.1753-4887.2007.tb00364.x
更新日期:2007-12-01 00:00:00
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journal_title:Nutrition reviews
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更新日期:2019-05-21 00:00:00
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更新日期:2003-05-01 00:00:00
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journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuaa060
更新日期:2020-09-11 00:00:00