Folic acid absorption, anticonvulsant and contraceptive therapy.

Abstract:

:Studies of the effects of oral contraceptives and other drugs on folic acid absorption are reviewed. In 1 study, estradiol, progesterone, and estrone did not inhibit folate conjugase nor interfere with the passage of folate conjugase across the lysosomal membrane. 12 women taking an oral contraceptive (norethisterone and ethinyl estradiol) had significantly higher mean serum folate levels at Day 20 of the menstrual cycle than at Day 5 (7.63 ng/ml and 5.36 ng/ml), though no significant difference was observed with compared with a control group. In another study, women taking oral contraceptives showed significantly lower mean peak serum folate levels after saturation with yeast polyglutamate when compared with controls. It is suggested that steroid hormones increase the rate of clearance of folate from the blood.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

doi

10.1111/j.1753-4887.1974.tb06260.x

subject

Has Abstract

pub_date

1974-02-01 00:00:00

pages

39-41

issue

2

eissn

0029-6643

issn

1753-4887

journal_volume

32

pub_type

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