Abstract：
:In response to recent studies from India suggesting that malnutrition, as assessed by anthropometric indexes, affects metabolism of oral progestogens, this study administered a mini-pill containing .35 mg of norethindrone (NET) and combination pills containing 250 or 150 mcg of d-norgestrel (d-NG) and either 50 or 30 mcg ethinyl estradiol as a single dose for fasting women of high and low income. Blood samples were collected for up to 24 hours for NET and 80 hours for the combination pills. Pharmacokinetics were evaluated by a least-squares method. Anthropometric measurements were also made. Peak NET levels occurred within 1-2 hours; half-life of plasma NET was shorter among low income, malnourished women compared with high income, well-nourished women. A direct correlation between weight/height and half-life of the drug suggests that malnutrition enhanation rate and reduces NET's half-life. Peak levels for d-NG also were reached between 1 and 2 hours after dosing. In well-nourished women, the decline in plasma d-NG was tri-exponential; malnourished women showed a biphasic curve with a neglible alpha-phase. Therefore, the lower the nutrition status, the faster the plasma clearance of these 2 orally administered compounds. Studies inn rabbits designed to elucidate this connection showed a significant elevation in specific activities of liver microsomal glucuronyl transferase and cytochrome-p450 in undernourished compared with control animals. There was also an increase in the amount (but not affinity) of uterine progesterone receptors in undernourished animals. Another study of a small group of Thai and Indian women showed positive correlation between anthropometric indexes and post peak plasma NET levels; however, an obesity study of Thai women found no such correlation.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
doi
10.1111/j.1753-4887.1984.tb02317.xsubject
Has Abstractpub_date
1984-05-01 00:00:00pages
182-3issue
5eissn
0029-6643issn
1753-4887journal_volume
42pub_type
杂志文章,评审abstract：:Studies of the effects of oral contraceptives and other drugs on folic acid absorption are reviewed. In 1 study, estradiol, progesterone, and estrone did not inhibit folate conjugase nor interfere with the passage of folate conjugase across the lysosomal membrane. 12 women taking an oral contraceptive (norethisteron...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1974.tb06260.x
更新日期：1974-02-01 00:00:00
abstract：:Recent studies of the effects of dietary fat on experimental carcinogenesis have probed the influence of the dietary fat source, the time during carcinogenesis when a high-fat diet is fed, the interactions between fat and calories, and the potential mechanisms for the observed effects of fat on cancer. The essential f...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1990.tb02870.x
更新日期：1990-01-01 00:00:00
abstract：:The Metabolic Syndrome, also known as Syndrome X, refers to a constellation of atherosclerotic risk factors, including insulin resistance, hyperinsulinemia, dyslipidemia, essential hypertension, and abdominal obesity. We review four major published studies involving animals and humans that may be linked together in a ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402320583398
更新日期：2002-10-01 00:00:00
abstract：:Undernutrition is a major contributor to child mortality and total global disease burden. Ready-to-use therapeutic food (RUTF) is recommended by the World Health Organization for community-based management of uncomplicated forms of severe acute malnutrition. New research has evaluated the role of RUTF for the preventi...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2010.00302.x
更新日期：2010-07-01 00:00:00
abstract：:Long-term metabolic studies indicate that over-feeding underfeeding to gain and lose body weight produce consistent increases and decreases in energy expenditure. These changes occur in both lean and obese subjects and cause deviations from the normal relationship between energy expenditure and metabolic body size. Th...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1995.tb05484.x
更新日期：1995-09-01 00:00:00
abstract：:Prospective studies suggest that dietary vitamin D may at least modestly reduce the risk of breast cancer. This review addresses issues raised by recent studies, including differences in findings related to dietary source of vitamin D, menopausal status, and tumor characteristics. It also discusses the optimal timing ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2007.tb00271.x
更新日期：2007-10-01 00:00:00
abstract：:Intrinsic aging of the brain and its relationship to age-related neurodegenerative diseases need to be understood as part of global aging, which results from gradual accumulation of a variety of kinds of cellular and molecular damage. While certain kinds of molecular lesions are particularly associated with specific d...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2010.00343.x
更新日期：2010-12-01 00:00:00
abstract：:A ventilator-dependent, extremely obese adolescent patient with Prader-Willi syndrome was nutritionally managed using a parenteral, protein-sparing modified fast. A solution containing only amino acids, electrolytes, vitamins, and macro- and micro-minerals helped create a ketotic state and facilitate weaning from the ...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1991.tb03035.x
更新日期：1991-08-01 00:00:00
abstract：:Low-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-dependent manner, bu...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuw059
更新日期：2017-02-01 00:00:00
abstract：:Despite a general lack of evidence for the carcinogenic effects of trans fatty acids, some recent research and popular media have suggested a possible association. The available scientific data do not support this relationship and are reviewed so as to put this issue in perspective. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1996.tb03916.x
更新日期：1996-05-01 00:00:00
abstract：CONTEXT:Serotonergic dysfunction, including reduced central serotonin levels, is associated with different psychiatric syndromes, including depression. As a serotonin precursor, 5-hydroxytryptophan has long been used as a nonpharmacological treatment for depression. OBJECTIVE:A systematic review and meta-analysis was ...
journal_title：Nutrition reviews
pub_type： 杂志文章,meta分析
doi：10.1093/nutrit/nuz039
更新日期：2020-01-01 00:00:00
abstract：Context:The metabolism of thyroid hormones, which are essential for normal development, involves many proteins and enzymes. It requires iodine as a key component but is also influenced by several other micronutrients, including selenium, zinc, iron, and vitamin A. Objective:This systematic review was designed to inves...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuy008
更新日期：2018-06-01 00:00:00
abstract：:Data from epidemiologic, experimental, and animal studies indicate that diet plays an important role in the etiology of gastric cancer. High intake of fresh fruits and vegetables, lycopene and lycopene-containing food products, and potentially vitamin C and selenium may reduce the risk for gastric cancer. Data also su...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2008.00029.x
更新日期：2008-05-01 00:00:00
abstract：:Glucokinase plays a major role in the control of hepatic glucose uptake and storage as glycogen. Small amounts of fructose-1-phosphate, in the presence of relatively high glucose levels, markedly stimulate glucokinase through a novel mechanism of regulation involving dissociation from a regulatory protein and transloc...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402320289377
更新日期：2002-08-01 00:00:00
abstract：:All-trans and 13-cis-retinoic acids are normal constituents of human blood. Blood levels of both compounds increase upon oral ingestion of all-trans-retinyl palmitate, to a greater extent with higher amounts of ingested retinyl palmitate. These data suggest a mechanism whereby levels of dietary vitamin A could influen...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1991.tb07423.x
更新日期：1991-09-01 00:00:00
abstract：:Perchlorate inhibits the uptake of iodide into the thyroid gland, thereby possibly affecting the synthesis of thyroid hormones. Pregnant women and their fetuses and newborns have the greatest potential for risk of adverse health effects following exposure to perchlorate. Perchlorate is present in some foods and in dri...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00260.x
更新日期：2010-01-01 00:00:00
abstract：Context:Dairy intake in humans is commonly assessed using questionnaires, but the data collected are often biased. As a result, there is increasing interest in biomarkers of dairy fat. To date, there has been no overview of the fatty acids suitable for use as biomarkers of dairy fat intake. Objective:This systematic r...
journal_title：Nutrition reviews
pub_type： 杂志文章,meta分析
doi：10.1093/nutrit/nuy048
更新日期：2019-01-01 00:00:00
abstract：:Several studies in very-low-birth-weight (VLBW) infants have investigated the effect of parenteral or enteral glutamine supplementation on morbidity, mortality, and outcome in the neonatal period. No evidence of toxicity of glutamine supplementation was found in these clinical trials, but the results for efficacy on a...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2010.00359.x
更新日期：2011-01-01 00:00:00
abstract：:The peroxisome proliferator-activated receptor (PPAR) β/δ has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPARβ/δ forms a heterodimer with the retinoic acid receptor and binds to peroxisome prolifera...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuz058
更新日期：2020-03-01 00:00:00
abstract：:Energy drinks are increasingly popular among athletes and others. Advertising for these products typically features images conjuring great muscle power and endurance; however, the scientific literature provides sparse evidence for an ergogenic role of energy drinks. Although the composition of energy drinks varies, mo...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/nure.12132
更新日期：2014-10-01 00:00:00
abstract：:The glucocorticoid dexamethasone (dex) stimulates differentiation of cultured preadipocytes of the 3T3-L1 cell line to adipocytes. The preadipocytes express a gene termed preadipocyte factor 1 (pref-1). The pref-1 gene product is abundant in preadipocytes but completely absent in adipocytes. Constitutive expression of...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1999.tb06907.x
更新日期：1999-10-01 00:00:00
abstract：:Chylomicrons have a suppressive effect on food consumption, which is attributed to apolipoprotein A-IV (apo A-IV). This protein is found in cerebrospinal fluid in vivo, and its infusion into the third ventricle of the brain reduces food intake. These findings suggest that this apolipoprotein operates through the centr...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1993.tb03120.x
更新日期：1993-09-01 00:00:00
abstract：:Introduction of chimeric transferrin-chloramphenicol acetyltransferase genes into transgenic mice provides a model by which modulation of the human transferrin gene may be studied in vivo. Iron injected into this mouse model decreases liver expression of the reporter enzyme in a manner analogous to its effect on plasm...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1991.tb03029.x
更新日期：1991-07-01 00:00:00
abstract：:Obesity is an established risk factor for postmenopausal, but not premenopausal, development of breast cancer. Evidence for a positive association between obesity and breast cancer mortality is mounting. Avoiding adult weight gain and maintaining a healthy body weight may contribute importantly to decreasing breast ca...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.febr.73-76
更新日期：2003-02-01 00:00:00
abstract：:Although body weight is considered to positively affect bones of children and adults, recent studies suggest that overweight and obesity in childhood and adolescence reduce bone mineral content below what would be predicted based on weight and are associated with an increase in incidence of childhood fractures. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402760240327
更新日期：2002-01-01 00:00:00
abstract：:The European Union is implementing a new regulatory framework for nutrition and health claims (HCs) that will greatly impact the communication of health messages on foodstuffs. In particular, approved HCs will be included in a positive register of generic claims. In the currently available literature, assessment of th...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2010.00322.x
更新日期：2010-10-01 00:00:00
abstract：:Despite forty years of research on the potential role of chromium in carbohydrate and lipid metabolism, significant progress has only recently been made regarding the mode of action of chromium at a molecular level. The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a nove...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2000.tb01841.x
更新日期：2000-03-01 00:00:00
abstract：:Two recent studies suggest that when consuming a low-calcium diet, low efficiency of calcium absorption (measured as fractional calcium absorption) is a problem in the elderly; this is also an important risk factor for hip fracture. These studies show that elderly women are less able to compensate for low calcium inta...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2001.tb06959.x
更新日期：2001-10-01 00:00:00
abstract：:Dietary management has been considered an alternative means of modulating adiponectin levels. The purpose of this review is to examine the scientific evidence regarding the effect of diet on adiponectin levels in blood. Clinical trials were selected from Medline until April 2010 using the following MeSH terms: adipoki...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00414.x
更新日期：2011-10-01 00:00:00
abstract：:International nutrition will become increasingly concerned with evaluation of nutritional status at the community level to diagnose situations of risk for nutrient deficits and excesses, and to monitor the impact of remedial interventions. Advances in biologic concepts and technology (particularly miniaturization of a...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/00296640260130876
更新日期：2002-05-01 00:00:00
