The molecular mechanism of the stimulation of adipocyte differentiation by a glucocorticoid.

Abstract:

:The glucocorticoid dexamethasone (dex) stimulates differentiation of cultured preadipocytes of the 3T3-L1 cell line to adipocytes. The preadipocytes express a gene termed preadipocyte factor 1 (pref-1). The pref-1 gene product is abundant in preadipocytes but completely absent in adipocytes. Constitutive expression of pref-1 blocks differentiation of adipocytes, as does a soluble 50 kDa fragment of the pref-1 protein. It appears that dex mediates adipogenesis by down-regulating expression of pref-1.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Wolf G

doi

10.1111/j.1753-4887.1999.tb06907.x

keywords:

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

324-6

issue

10

eissn

0029-6643

issn

1753-4887

journal_volume

57

pub_type

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