Abstract：
:A large number of biologically active components have been found in human milk (HM), and in both human and animal models, studies have provided some evidence suggesting that HM composition can be altered by maternal exposures, subsequently influencing health outcomes for the breastfed child. Evidence varies from the research studies on whether breastfeeding protects the offspring from noncommunicable diseases, including those associated with immunological dysfunction. It has been hypothesized that the conflicting evidence results from HM composition variations, which contain many immune active molecules, oligosaccharides, lactoferrin, and lysozyme in differing concentrations, along with a diverse microbiome. Determining the components that influence infant health outcomes in terms of both short- and long-term sequelae is complicated by a lack of understanding of the environmental factors that modify HM constituents and thereby offspring outcomes. Variations in HM immune and microbial composition (and the differing infantile responses) may in part explain the controversies that are evidenced in studies that aim to evaluate the prevalence of allergy by prolonged and exclusive breastfeeding. HM is a "mixture" of immune active factors, oligosaccharides, and microbes, which all may influence early immunological outcomes. This comprehensive review provides an in-depth overview of existing evidence on the studied relationships between maternal exposures, HM composition, vaccine responses, and immunological outcomes.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Boix-Amorós A,Collado MC,Van't Land B,Calvert A,Le Doare K,Garssen J,Hanna H,Khaleva E,Peroni DG,Geddes DT,Kozyrskyj AL,Warner JO,Munblit Ddoi
10.1093/nutrit/nuz019subject
Has Abstractpub_date
2019-05-21 00:00:00eissn
0029-6643issn
1753-4887pii
5492496pub_type
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journal_title：Nutrition reviews
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更新日期：1966-04-01 00:00:00
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更新日期：2014-10-01 00:00:00
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更新日期：2018-06-01 00:00:00
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