Obesity, lutein metabolism, and age-related macular degeneration: a web of connections.

Abstract:

:Age-related macular degeneration (AMD) is a major cause of visual impairment in the United States. Currently there is no effective cure for this disease. Risk factors include decreased lutein and zeaxanthin status and obesity. Obesity is also an increasing public health concern. The alarming increase in the prevalence of obesity further exacerbates the public health concern of AMD. The mechanism by which obesity increases the risk of AMD may be related to the physiologic changes that occur with this condition. These include increased oxidative stress, changes in the lipoprotein profile, and increased inflammation. These changes would also result in an increased destruction and a decreased circulatory delivery of lutein and zeaxanthin to the macula of the eye. Therefore, the mechanism by which obesity is related to AMD risk may be through indirect effects on changes in lutein and zeaxanthin status and metabolism.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Johnson EJ

doi

10.1111/j.1753-4887.2005.tb00105.x

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

9-15

issue

1

eissn

0029-6643

issn

1753-4887

journal_volume

63

pub_type

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