Abstract:
:Age-related macular degeneration (AMD) is a major cause of visual impairment in the United States. Currently there is no effective cure for this disease. Risk factors include decreased lutein and zeaxanthin status and obesity. Obesity is also an increasing public health concern. The alarming increase in the prevalence of obesity further exacerbates the public health concern of AMD. The mechanism by which obesity increases the risk of AMD may be related to the physiologic changes that occur with this condition. These include increased oxidative stress, changes in the lipoprotein profile, and increased inflammation. These changes would also result in an increased destruction and a decreased circulatory delivery of lutein and zeaxanthin to the macula of the eye. Therefore, the mechanism by which obesity is related to AMD risk may be through indirect effects on changes in lutein and zeaxanthin status and metabolism.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Johnson EJdoi
10.1111/j.1753-4887.2005.tb00105.xkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
9-15issue
1eissn
0029-6643issn
1753-4887journal_volume
63pub_type
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