Folate, vitamin B12, and neuropsychiatric disorders.

Abstract:

:Folate and vitamin B12 are required both in the methylation of homocysteine to methionine and in the synthesis of S-adenosylmethionine. S-adenosylmethionine is involved in numerous methylation reactions involving proteins, phospholipids, DNA, and neurotransmitter metabolism. Both folate and vitamin B12 deficiency may cause similar neurologic and psychiatric disturbances including depression, dementia, and a demyelinating myelopathy. A current theory proposes that a defect in methylation processes is central to the biochemical basis of the neuropsychiatry of these vitamin deficiencies. Folate deficiency may specifically affect central monoamine metabolism and aggravate depressive disorders. In addition, the neurotoxic effects of homocysteine may also play a role in the neurologic and psychiatric disturbances that are associated with folate and vitamin B12 deficiency.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Bottiglieri T

doi

10.1111/j.1753-4887.1996.tb03851.x

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

382-90

issue

12

eissn

0029-6643

issn

1753-4887

journal_volume

54

pub_type

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