Pharmacological effects and clinical applications of propionyl-L-carnitine.

Abstract:

:Propionyl-L-carnitine (PLC) is a naturally occurring derivative of carnitine that plays an important role in the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation. PLC, however, is not only a metabolic drug; it is also a potent antiradical agent and thus may protect tissues from oxidative damage. PLC has been demonstrated to exert a protective effect in different models of both cardiac and endothelial dysfunction, to prevent the progression of atherosclerosis, and, more recently, to improve some of the cardiometabolic alterations that frequently accompany insulin resistance. As a result, most of the clinical trials conducted in humans highlight PLC as a potential treatment option in cardiovascular diseases such as peripheral arterial disease, chronic heart failure, or stable angina, especially when type 2 diabetes mellitus or hyperglycemia (i.e., patients on hemodialysis) are also present. The aim of this review is to summarize the pharmacological effects and possible therapeutic applications of PLC, including the most recent findings to date.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Mingorance C,Rodriguez-Rodriguez R,Justo ML,Herrera MD,de Sotomayor MA

doi

10.1111/j.1753-4887.2011.00387.x

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

279-90

issue

5

eissn

0029-6643

issn

1753-4887

journal_volume

69

pub_type

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