Abstract:
:Propionyl-L-carnitine (PLC) is a naturally occurring derivative of carnitine that plays an important role in the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation. PLC, however, is not only a metabolic drug; it is also a potent antiradical agent and thus may protect tissues from oxidative damage. PLC has been demonstrated to exert a protective effect in different models of both cardiac and endothelial dysfunction, to prevent the progression of atherosclerosis, and, more recently, to improve some of the cardiometabolic alterations that frequently accompany insulin resistance. As a result, most of the clinical trials conducted in humans highlight PLC as a potential treatment option in cardiovascular diseases such as peripheral arterial disease, chronic heart failure, or stable angina, especially when type 2 diabetes mellitus or hyperglycemia (i.e., patients on hemodialysis) are also present. The aim of this review is to summarize the pharmacological effects and possible therapeutic applications of PLC, including the most recent findings to date.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Mingorance C,Rodriguez-Rodriguez R,Justo ML,Herrera MD,de Sotomayor MAdoi
10.1111/j.1753-4887.2011.00387.xsubject
Has Abstractpub_date
2011-05-01 00:00:00pages
279-90issue
5eissn
0029-6643issn
1753-4887journal_volume
69pub_type
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