Abstract：
:Recently published literature has been reviewed to determine whether lycopene, beta-carotene, alpha-carotene, and beta-cryptoxanthin are associated with reductions in cancer risk and whether study findings differ by study design. A total of 57 publications meeting pre-defined inclusion and exclusion criteria were identified, with the majority (55) being observational studies. None of the intervention studies supported a significant reduction in cancer risk with carotenoid (beta-carotene) supplementation. The majority of observational studies did not support significant reductions in cancer risk with increased carotenoid dietary intakes/circulating levels. A larger percentage of case-control studies supported significant associations between increased dietary intakes/circulating levels of carotenoids relative to prospective (cohort and nested case-control) studies. Compared to prospective studies, case-control studies cannot be used to establish temporality and may be more susceptible to selection and recall biases. Thus, diet-disease relationships suggested by case-control studies should ideally be confirmed by additional evidence from prospective studies.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Musa-Veloso K,Card JW,Wong AW,Cooper DAdoi
10.1111/j.1753-4887.2009.00225.xsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
527-45issue
9eissn
0029-6643issn
1753-4887pii
NURE225journal_volume
67pub_type
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journal_title：Nutrition reviews
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journal_title：Nutrition reviews
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更新日期：2007-11-01 00:00:00
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journal_title：Nutrition reviews
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更新日期：2017-02-01 00:00:00
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更新日期：2003-03-01 00:00:00
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