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Efficacy of fish oil and its components in the management of psoriasis: a systematic review of 18 randomized controlled trials.

Abstract：

CONTEXT:Fish oil and omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have anti-inflammatory properties, but their effect on psoriasis and its comorbidities remains inconclusive. OBJECTIVE:The aim of this quantitative systematic review was to evaluate the efficacy and safety of fish oil and its components in the treatment of psoriasis and its comorbidities. DATA SOURCES:PubMed, Embase, Cochrane Central Register of Controlled Trials, China Network Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang databases were searched from inception to March 30, 2019. STUDY SELECTION:Randomized controlled trials were eligible for inclusion if they measured the effect of fish oil and its components in the treatment of patients with psoriasis. DATA EXTRACTION:Eighteen randomized controlled trials involving 927 study participants were included. RESULTS:Monotherapy with fish oil or ω-3 PUFAs had no effect on the Psoriasis Area and Severity Index (PASI) score (P = 0.47), lesion area (P = 0.34), or pruritus (P = 0.62). Fish oil or ω-3 PUFAs combined with conventional treatments, however, resulted in a decreased PASI score (mean difference [MD], -3.92; 95%CI, -6.15 to -1.69; P = 0.0006) and lesion area (MD, -30.00; 95%CI, -33.82 to -26.18; P < 0.0001). Safety evaluation suggested no between-group differences. Fish oil and its components reduced certain risk factors for obesity, cardiovascular disease, and metabolic disease in patients with psoriasis and also regulated several inflammatory mediators. CONCLUSIONS:Overall, when combined with conventional treatments, fish oil and its components may have beneficial effects on psoriasis and its comorbidities, including obesity, cardiovascular disease, and metabolic disease. SYSTEMATIC REVIEW REGISTRATION:PROSPERO registration number CRD42019128631.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Chen X,Hong S,Sun X,Xu W,Li H,Ma T,Zheng Q,Zhao H,Zhou Y,Qiang Y,Li B,Li X

doi

10.1093/nutrit/nuz098

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

827-840

issue

eissn

0029-6643

issn

1753-4887

pii

5717452

journal_volume

pub_type

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Efficacy of fish oil and its components in the management of psoriasis: a systematic review of 18 randomized controlled trials.