Nutritional strategies to modulate inflammation pathways via regulation of peroxisome proliferator-activated receptor β/δ.

Abstract:

:The peroxisome proliferator-activated receptor (PPAR) β/δ has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPARβ/δ forms a heterodimer with the retinoic acid receptor and binds to peroxisome proliferator response elements to initiate transcription of its target genes. PPARβ/δ is also able to suppress the activities of several transcription factors, including nuclear factor κB, and activator protein 1, thus regulating anti-inflammatory cellular responses and playing a protective role in several diseases. Recent studies have shown that nutritional compounds, including nutrients and bioactive compounds, can regulate PPARβ/δ expression. This review discusses key nutritional compounds that are known to modulate PPARβ/δ and are likely to affect human health.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

da Cruz BO,Cardozo LFMF,Magliano DC,Stockler-Pinto MB

doi

10.1093/nutrit/nuz058

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

207-214

issue

3

eissn

0029-6643

issn

1753-4887

pii

5581263

journal_volume

78

pub_type

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