Abstract:
:The peroxisome proliferator-activated receptor (PPAR) β/δ has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPARβ/δ forms a heterodimer with the retinoic acid receptor and binds to peroxisome proliferator response elements to initiate transcription of its target genes. PPARβ/δ is also able to suppress the activities of several transcription factors, including nuclear factor κB, and activator protein 1, thus regulating anti-inflammatory cellular responses and playing a protective role in several diseases. Recent studies have shown that nutritional compounds, including nutrients and bioactive compounds, can regulate PPARβ/δ expression. This review discusses key nutritional compounds that are known to modulate PPARβ/δ and are likely to affect human health.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
da Cruz BO,Cardozo LFMF,Magliano DC,Stockler-Pinto MBdoi
10.1093/nutrit/nuz058subject
Has Abstractpub_date
2020-03-01 00:00:00pages
207-214issue
3eissn
0029-6643issn
1753-4887pii
5581263journal_volume
78pub_type
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journal_title:Nutrition reviews
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journal_title:Nutrition reviews
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journal_title:Nutrition reviews
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journal_title:Nutrition reviews
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journal_title:Nutrition reviews
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