Abstract：
CONTEXT:Serotonergic dysfunction, including reduced central serotonin levels, is associated with different psychiatric syndromes, including depression. As a serotonin precursor, 5-hydroxytryptophan has long been used as a nonpharmacological treatment for depression. OBJECTIVE:A systematic review and meta-analysis was conducted to determine the antidepressant effects of 5-hydroxytryptophan in depressed patients. DATA SOURCES:MEDLINE (via PubMed) and Google Scholar were searched from inception to May 2018. DATA EXTRACTION:Thirteen investigations were included in the systematic review (using PRISMA guidelines), and 7 in the full meta-analysis (pre-registered on PROSPERO: CRD42018104415). DATA ANALYSIS:Analyses revealed a depression remission rate of 0.65 (95% confidence interval [CI], 0.55-0.78; remission rate [k] = 13), and this was confirmed by the questionnaire results, which revealed a large Hedges' g (1.11; 95%CI, 0.53-1.69). Methodological variability (in treatment duration, type of depression studied, experimental design, 5-hydroxytryptophan dosage) contributes to heterogeneity in the results (I2 = 76%, τ2 = 0.379). In addition, the OHAT (Office of Health Assessment and Translation risk of bias rating) tool suggested that, on the whole, current studies are relatively weak (few include placebo groups). CONCLUSION:Further trials should overcome these limitations by using placebo-controlled studies that include patients with well-defined depression diagnoses, along with strong characterization of psychological and physiological patient characteristics.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Javelle F,Lampit A,Bloch W,Häussermann P,Johnson SL,Zimmer Pdoi
10.1093/nutrit/nuz039subject
Has Abstractpub_date
2020-01-01 00:00:00pages
77-88issue
1eissn
0029-6643issn
1753-4887pii
5555860journal_volume
78pub_type
杂志文章,meta分析abstract：:Thermal injury in animal models clearly alters glucose metabolism. Insulin resistance results, with the wound in the skin receiving increased glucose, presumably to be used for wound healing and fighting invasion by foreign organisms. Using the whole-body imaging capacities of PET, it may now be possible to explore in...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1998.tb01636.x
更新日期：1998-01-01 00:00:00
abstract：:Obesity is an established risk factor for postmenopausal, but not premenopausal, development of breast cancer. Evidence for a positive association between obesity and breast cancer mortality is mounting. Avoiding adult weight gain and maintaining a healthy body weight may contribute importantly to decreasing breast ca...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.febr.73-76
更新日期：2003-02-01 00:00:00
abstract：:The role of maternal vitamin A supplements in decreasing the risk of mother-to-child HIV transmission has been examined in sub-Saharan Africa. Overall, there is no reduction in either mortality or HIV transmission in two recent studies. Contrary to expectations, one study reported an increased risk of transmission usi...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.aug.280-284
更新日期：2003-08-01 00:00:00
abstract：:This case report describes a 14-month-old Guatemalan boy suffering from diarrhea and malnutrition. He had been healthy and experienced normal growth until weaning, which began at six months of age. Introduction of semisolid foods at this time was accompanied by bouts of diarrhea and a reduced growth rate. After admiss...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1990.tb02937.x
更新日期：1990-05-01 00:00:00
abstract：:The human body is an ecosystem harboring complex site-specific microbial communities. The majority of these human-associated microbes are found in the intestinal tract, where they play important roles in energy uptake, vitamin synthesis, and epithelial and immunity development. Recent molecular studies have characteri...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00237.x
更新日期：2009-11-01 00:00:00
abstract：:Reported here is a summary of the proceedings of the Symposium on Plant Polyphenols: Nutrition, Health and Innovations, which was cosponsored by the Southeast Asia Region branch of the International Life Sciences Institute and the Nutrition Society of Malaysia in Kuala Lumpur, Malaysia, June 22-23, 2009. The symposium...
journal_title：Nutrition reviews
pub_type：
doi：10.1111/j.1753-4887.2010.00283.x
更新日期：2010-04-01 00:00:00
abstract：:The African grain deficit is projected to surpass its current production of 50 x 10(6) metric tons/year by the turn of the century. The biodiversity of the African continent, on which there are more native cereals than on any other continent, can serve to reduce the vulnerability of the continent's populations at seri...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1998.tb01767.x
更新日期：1998-09-01 00:00:00
abstract：:Prospective studies suggest that dietary vitamin D may at least modestly reduce the risk of breast cancer. This review addresses issues raised by recent studies, including differences in findings related to dietary source of vitamin D, menopausal status, and tumor characteristics. It also discusses the optimal timing ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2007.tb00271.x
更新日期：2007-10-01 00:00:00
abstract：:Fetal malnutrition has been associated with maturational defect in cell metabolism. A series of studies on anthropometric and clinical aspects of patients with intrauterine malnutrition was conducted to establish the relationship between intrauterine growth failure and cell function. The 1st study assessed intrauter...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1973.tb05171.x
更新日期：1973-06-01 00:00:00
abstract：:The present systematic review was performed to assess differences in the worldwide consumption of functional foods. The Medline and Scopus databases were used to search the existing literature. A total of 23 studies that examined functional food consumption and included information on the country, gender, and age of p...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2012.00492.x
更新日期：2012-08-01 00:00:00
abstract：:Megaloblastic anemia may well not be the only consequence of folic acid deficiency in pregnancy. An association has been noted between other maternal and fetal hazards and folate deficiency. ...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1111/j.1753-4887.1968.tb00810.x
更新日期：1968-01-01 00:00:00
abstract：:The body of knowledge about plants, herbs, and spices and their respective and collective roles in promoting human health is modest. Flavonoids in tea and anthocyanins in tart cherries were presented as examples of how to move forward in understanding active compounds. Dietary compounds, their roles in maintaining hum...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1999.tb01806.x
更新日期：1999-09-01 00:00:00
abstract：:Worldwide, the number of individuals who are co-infected with human immunodeficiency virus (HIV) and tuberculosis is increasing greatly. The "triple trouble" of HIV and tuberculosis infection and malnutrition may put those infected at greater risk than those with any of the three conditions alone. Further investigatio...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.marr.81-90
更新日期：2003-03-01 00:00:00
abstract：:Functional genomics, commonly applied to the genes and enzymes involved in metabolism of chemicals, can also be applied to enzymes involved in the metabolism of nutrients. Although in its infancy, genomics can be used to determine relationships between nutrition and toxicology, drug metabolism, and cancer. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2001.tb05510.x
更新日期：2001-08-01 00:00:00
abstract：:It has become increasingly evident in recent years that the gut microbiome and the brain communicate in a bidirectional manner, with each possibly affecting the other's functions. Substantial research has aimed to understand the mechanisms of this interaction and to outline strategies for preventing or treating nervou...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuy009
更新日期：2018-07-01 00:00:00
abstract：:Adequate folate status in early pregnancy is critical to prevent congenital malformations, yet little is known about whether exposure to folate, specifically folic acid supplementation beyond the recommended dose, influences chronic health outcomes. The link between maternal folate levels and risk of childhood asthma ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/nure.12080
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The primary aim of the current study was to synthesize evidence of the effect of social media use compared with no social media use as part of interventions to reduce risk factors for noncommunicable diseases. DATA SOURCES:Databases were searched up to June 10, 2014, using medical subject headings. A seconda...
journal_title：Nutrition reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1093/nutrit/nuv106
更新日期：2016-04-01 00:00:00
abstract：:Fish and shellfish are widely available foods that provide important nutrients, particularly n-3 polyunsaturated fatty acids (n-3 PUFAs), to many populations globally. These nutrients, especially docosahexaenoic acid, confer benefits to brain and visual system development in infants and reduce risks of certain forms o...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00415.x
更新日期：2011-09-01 00:00:00
abstract：:This review critically summarizes the literature on neighborhood determinants of obesity and proposes a conceptual framework to guide future inquiry. Thirty-seven studies met all inclusion criteria and revealed that the influence of neighborhood-level factors appears mixed. Neighborhood-level measures of economic reso...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2007.00001.x
更新日期：2008-01-01 00:00:00
abstract：:The regulatory properties of a principal glutamine transport system of skeletal muscle may control the balance between muscle protein synthesis and breakdown. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1989.tb02843.x
更新日期：1989-07-01 00:00:00
abstract：:The optimal timing of umbilical cord clamping has been debated in the scientific literature for at least the last century, when cord clamping practices shifted from delayed towards immediate clamping. Recent research provides evidence for the beneficial effect of delayed cord clamping on infant iron status. The presen...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00430.x
更新日期：2011-11-01 00:00:00
abstract：:Results from human feeding studies and recent large-scale epidemiologic surveys suggest that dietary trans fatty acids enhance the risk of developing coronary heart diseases. Despite a lack of accurate data regarding dietary intake of trans fatty acids, existing epidemiologic data and evidence from experimental feedin...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1998.tb01758.x
更新日期：1998-08-01 00:00:00
abstract：:Malnourished children experience more severe measles infections at a greater frequency than well nourished children. In Africa, the mortality rate for measles infection is 25-50% in infants and young children with edematous malnutrition. There is some evidence that the altered immune responses of malnourished people...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1982.tb05310.x
更新日期：1982-07-01 00:00:00
abstract：:A relationship between folate and neuropsychiatric disorders has been inferred from clinical observation and from the enhanced understanding of the role of folate in critical brain metabolic pathways. Depressive symptoms are the most common neuropsychiatric manifestation of folate deficiency. Conversely, borderline lo...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1997.tb06468.x
更新日期：1997-05-01 00:00:00
abstract：:Isoflavones present in soy may have risk and benefits to human health. Human gut microflora have been shown to exert metabolic activities on isoflavones, which influences bioavailability and bioactivity. Absorption of isoflavones is likely to occur in the small intestine where there is a diverse range of microfloral s...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.jun.204-213
更新日期：2003-06-01 00:00:00
abstract：:This conference resulted in a foundation upon which consensus will be built in the future. Further, it provided a forum for the articulation of the critical need for carbohydrates in human nutrition. We have come a long way in the past 25 years in the food and nutrition sciences and this conference well illustrated th...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1995.tb01549.x
更新日期：1995-07-01 00:00:00
abstract：:Mammalian cells use an exquisitely sensitive mechanism to control the amount of cholesterol and fatty acids in their membranes. This process relies on a feedback system that adjusts the rates of transcription of genes encoding the low density lipoprotein receptor and multiple enzymes in the cholesterol and fatty acid ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1998.tb01680.x
更新日期：1998-02-01 00:00:00
abstract：:International nutrition will become increasingly concerned with evaluation of nutritional status at the community level to diagnose situations of risk for nutrient deficits and excesses, and to monitor the impact of remedial interventions. Advances in biologic concepts and technology (particularly miniaturization of a...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/00296640260130876
更新日期：2002-05-01 00:00:00
abstract：:In response to recent studies from India suggesting that malnutrition, as assessed by anthropometric indexes, affects metabolism of oral progestogens, this study administered a mini-pill containing .35 mg of norethindrone (NET) and combination pills containing 250 or 150 mcg of d-norgestrel (d-NG) and either 50 or 30 ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1984.tb02317.x
更新日期：1984-05-01 00:00:00
abstract：:Evidence mapping is a useful methodology for characterizing existing research on a broad topic and identifying gaps in the scientific literature. Evidence mapping entails conducting a systematic literature search and extracting information on study details, often in the form of a database. Researchers at Tufts Univers...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuz062
更新日期：2020-08-01 00:00:00
