Abstract:
:Mammalian cells use an exquisitely sensitive mechanism to control the amount of cholesterol and fatty acids in their membranes. This process relies on a feedback system that adjusts the rates of transcription of genes encoding the low density lipoprotein receptor and multiple enzymes in the cholesterol and fatty acid biosynthetic pathways. When cellular cholesterol levels are depleted, these genes are all transcribed in abundant amounts, and their transcription is repressed when sterols build up within the cell. Until recently, the mechanism of this regulation was elusive. How do cells sense the level of a membrane-embedded lipid such as cholesterol and how is this information transmitted to the nucleus where gene transcription is regulated? Answers are now beginning to emerge from the study of a newly discovered family of transcription-regulating proteins called sterol regulatory element binding proteins.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Brown MS,Goldstein JLdoi
10.1111/j.1753-4887.1998.tb01680.xsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
S1-3; discussion S54-75issue
2 Pt 2eissn
0029-6643issn
1753-4887journal_volume
56pub_type
杂志文章,评审abstract::Restriction of copper intake during lactation and postlactation periods reduced T cells and increased interleukin-2 receptors in isolated splenocytes from male, but not female, rats. However, a reduced in vitro proliferative response to phytohemagglutin (PHA) was seen in both male and female Cu-deficient rats. These f...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1992.tb01300.x
更新日期:1992-04-01 00:00:00
abstract::Advanced glycation end products (AGEs) formed via the Maillard reaction during the thermal processing of food contributes to the flavor, color, and aroma of food. A proportion of food-derived AGEs and their precursors is intestinally absorbed and accumulates within cells and tissues. AGEs have been implicated in the p...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1093/nutrit/nuv030
更新日期:2015-11-01 00:00:00
abstract::Two recent studies suggest that when consuming a low-calcium diet, low efficiency of calcium absorption (measured as fractional calcium absorption) is a problem in the elderly; this is also an important risk factor for hip fracture. These studies show that elderly women are less able to compensate for low calcium inta...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2001.tb06959.x
更新日期:2001-10-01 00:00:00
abstract:INTRODUCTION:The omega-3 long-chain polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are important for brain development and cognitive performance. Because they are semi-essential fatty acids, they must be obtained from food. However, the dietary reference intakes of DHA and EPA ha...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuaa060
更新日期:2020-09-11 00:00:00
abstract:CONTEXT:The impact of various dietary interventions on rheumatoid arthritis (RA), characterized by immune-inflammatory response, has been subject to increased attention. OBJECTIVE:A systematic review was conducted to update the current knowledge on the effects of nutritional, dietary supplement, and fasting interventi...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuaa033
更新日期:2020-06-25 00:00:00
abstract:OBJECTIVE:The primary aim of the current study was to synthesize evidence of the effect of social media use compared with no social media use as part of interventions to reduce risk factors for noncommunicable diseases. DATA SOURCES:Databases were searched up to June 10, 2014, using medical subject headings. A seconda...
journal_title:Nutrition reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1093/nutrit/nuv106
更新日期:2016-04-01 00:00:00
abstract::We present a case of the eosinophilia-myalgia syndrome in a patient taking large doses of L-tryptophan for sedation. He developed the now-classic findings of myalgias, skin changes, and marked eosinophilia. This syndrome was first recognized in late 1989, and epidemiologic studies have demonstrated an association of t...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1990.tb02969.x
更新日期:1990-08-01 00:00:00
abstract::Disagreement about the use of animals in biomedical research has resulted in absurd positions by both sides. Increasingly, some zealots against animal experimentation have resorted to violence or other illegal acts to support their points of view. The value of animal research in providing better health for man and ani...
journal_title:Nutrition reviews
pub_type: 历史文章,杂志文章
doi:10.1111/j.1753-4887.2008.00144.x
更新日期:2009-02-01 00:00:00
abstract::Malnourished children experience more severe measles infections at a greater frequency than well nourished children. In Africa, the mortality rate for measles infection is 25-50% in infants and young children with edematous malnutrition. There is some evidence that the altered immune responses of malnourished people...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1982.tb05310.x
更新日期:1982-07-01 00:00:00
abstract::Seaweeds may have an important role in modulating chronic disease. Rich in unique bioactive compounds not present in terrestrial food sources, including different proteins (lectins, phycobiliproteins, peptides, and amino acids), polyphenols, and polysaccharides, seaweeds are a novel source of compounds with potential ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12091
更新日期:2014-03-01 00:00:00
abstract:CONTEXT:Contrary to nutritional guidelines, accumulating evidence shows that pregnant women's energy intakes remain stable throughout trimesters. Although pregnant women may eat below their needs or underreport their energy intakes, it is also relevant to question how energy requirements - estimated through measurement...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuaa093
更新日期:2020-09-25 00:00:00
abstract::Adequate folate status in early pregnancy is critical to prevent congenital malformations, yet little is known about whether exposure to folate, specifically folic acid supplementation beyond the recommended dose, influences chronic health outcomes. The link between maternal folate levels and risk of childhood asthma ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12080
更新日期:2014-01-01 00:00:00
abstract::Long-term metabolic studies indicate that over-feeding underfeeding to gain and lose body weight produce consistent increases and decreases in energy expenditure. These changes occur in both lean and obese subjects and cause deviations from the normal relationship between energy expenditure and metabolic body size. Th...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1995.tb05484.x
更新日期:1995-09-01 00:00:00
abstract::Intestinal adaptation, in terms of increasing intestinal length and weight, usually occurs rapidly after small-bowel resection. However, this response depends on provision of enteral nutrients. If total parenteral nutrition without enteral feeding is prolonged, hypoplasia of the intestinal mucosa results. Adaptation i...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1989.tb02837.x
更新日期:1989-07-01 00:00:00
abstract::Chronic stress causes the release of glucocorticoids, which greatly influence cerebral function, especially glutamatergic transmission. These stress-induced changes in neurotransmission could be counteracted by increasing the dietary intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs). Numerous studies have desc...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12088
更新日期:2014-02-01 00:00:00
abstract::In vitro studies and some clinical studies suggest that vitamin D plays an important role in reducing inflammation. The objective of this review was to examine recent evidence that vitamin D status influences the level of inflammation in adults without acute illness or injury. Five large cross-sectional studies and tw...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12095
更新日期:2014-02-01 00:00:00
abstract::Dietary management has been considered an alternative means of modulating adiponectin levels. The purpose of this review is to examine the scientific evidence regarding the effect of diet on adiponectin levels in blood. Clinical trials were selected from Medline until April 2010 using the following MeSH terms: adipoki...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2011.00414.x
更新日期:2011-10-01 00:00:00
abstract::Despite forty years of research on the potential role of chromium in carbohydrate and lipid metabolism, significant progress has only recently been made regarding the mode of action of chromium at a molecular level. The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a nove...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2000.tb01841.x
更新日期:2000-03-01 00:00:00
abstract::It has become increasingly evident in recent years that the gut microbiome and the brain communicate in a bidirectional manner, with each possibly affecting the other's functions. Substantial research has aimed to understand the mechanisms of this interaction and to outline strategies for preventing or treating nervou...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1093/nutrit/nuy009
更新日期:2018-07-01 00:00:00
abstract::Patients in the intensive care unit are at high risk of glutamine depletion and subsequent complications. Several controlled studies and a meta-analysis have concluded that glutamine supplementation has beneficial effects on the clinical outcome of critically ill and surgical patients. These results may be explained b...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2005.tb00123.x
更新日期:2005-02-01 00:00:00
abstract::The labeling of health claims that meet the significant scientific agreement (SSA) standard (authorized health claims) and qualified health claims on conventional foods and dietary supplements requires premarket approval by the US Food and Drug Administration (FDA). FDA conducts an evidence-based review to determine w...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2007.tb00284.x
更新日期:2007-02-01 00:00:00
abstract::Outbreaks of foodborne disease owing to contamination with Listeria monocytogenes bacteria have usually been associated with the development of severe invasive disease. A recent report has provided clear documentation showing that outbreaks of L. monocytogenes also present as gastroenteritis and fever. Further studies...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1997.tb01597.x
更新日期:1997-02-01 00:00:00
abstract::The complementary feeding period, when solids and liquids other than breast milk and formula are added to the infant diet, is an important development window shaping infant growth and weight gain, metabolic development, and lifelong eating practices. Yet, relatively little is known about how the timing and types of fo...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuz057
更新日期:2020-12-01 00:00:00
abstract::Studying the effects of dehydration on cognitive function presents a variety of unique and difficult challenges to investigators. These challenges, which are addressed in this article, can be divided into three general categories: 1) choosing an appropriate method of generating a consistent level of dehydration; 2) de...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2012.00524.x
更新日期:2012-11-01 00:00:00
abstract::A recent study on lactose intolerance and irritable bowel syndrome has shown that subjective lactose intolerance is increased in patients with irritable bowel syndrome, despite no increase in the prevalence of lactose maldigestion. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1998.tb01665.x
更新日期:1998-10-01 00:00:00
abstract::The daily subcutaneous injection of 0.3 U/kg of recombinant growth hormone (GH) for the two years prior to puberty in ten constitutionally growth-retarded children with normal pituitary function resulted in an average height gain of 10 cm per year. No manifestations of GH excess were seen, and a transient alteration i...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1992.tb01326.x
更新日期:1992-07-01 00:00:00
abstract::A new study of the possible advantages of each of the eight dipeptides for intravenous nutrition focuses on kinetics of tyrosine and glutamine injected intravenously. Tyrosine and glutamine are two of the three amino acids that are difficult to use directly in the preparation of nutrient solutions due to low solubilit...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1995.tb01529.x
更新日期:1995-04-01 00:00:00
abstract:CONTEXT:The presence of retail food establishments around schools can be a potentiating or protective factor for overweight in students, depending on access to these places as well as types of foods available therein. The hypothesis for this study was that a greater density and proximity of retail food establishments a...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuz110
更新日期:2020-10-01 00:00:00
abstract::Intrinsic aging of the brain and its relationship to age-related neurodegenerative diseases need to be understood as part of global aging, which results from gradual accumulation of a variety of kinds of cellular and molecular damage. While certain kinds of molecular lesions are particularly associated with specific d...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2010.00343.x
更新日期:2010-12-01 00:00:00
abstract::Isoflavones present in soy may have risk and benefits to human health. Human gut microflora have been shown to exert metabolic activities on isoflavones, which influences bioavailability and bioactivity. Absorption of isoflavones is likely to occur in the small intestine where there is a diverse range of microfloral s...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/nr.2003.jun.204-213
更新日期:2003-06-01 00:00:00