Abstract:
:Advanced glycation end products (AGEs) formed via the Maillard reaction during the thermal processing of food contributes to the flavor, color, and aroma of food. A proportion of food-derived AGEs and their precursors is intestinally absorbed and accumulates within cells and tissues. AGEs have been implicated in the pathogenesis of diabetes-related complications and several chronic diseases via interaction with the receptor for AGEs, which promotes the transcription of genes that control inflammation. The dicarbonyls, highly reactive intermediates of AGE formation, are also generated during food processing and may incite inflammatory responses through 1) the suppression of protective pathways, 2) the incretin axis, 3) the modulation of immune-mediated signaling, and 4) changes in gut microbiota profile and metabolite sensors. In animal models, restriction of dietary AGEs attenuates chronic low-grade inflammation, but current evidence from human studies is less clear. Here, the emerging relationship between excess dietary AGE consumption and inflammation is explored, the utility of dietary AGE restriction as a therapeutic strategy for the attenuation of chronic diseases is discussed, and possible avenues for future investigation are suggested.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Kellow NJ,Coughlan MTdoi
10.1093/nutrit/nuv030subject
Has Abstractpub_date
2015-11-01 00:00:00pages
737-59issue
11eissn
0029-6643issn
1753-4887pii
nuv030journal_volume
73pub_type
杂志文章,评审abstract:CONTEXT:The impact of dietary protein on body composition changes after older adults purposefully lose weight requires systematic evaluation OBJECTIVE:: This systematic review and meta-analysis assessed the effects of protein intake (< 25% vs ≥ 25% of energy intake or 1.0 g/kg/d) on energy restriction-induced changes ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1093/nutrit/nuv065
更新日期:2016-03-01 00:00:00
abstract::Malnourished children experience more severe measles infections at a greater frequency than well nourished children. In Africa, the mortality rate for measles infection is 25-50% in infants and young children with edematous malnutrition. There is some evidence that the altered immune responses of malnourished people...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1982.tb05310.x
更新日期:1982-07-01 00:00:00
abstract::Perchlorate inhibits the uptake of iodide into the thyroid gland, thereby possibly affecting the synthesis of thyroid hormones. Pregnant women and their fetuses and newborns have the greatest potential for risk of adverse health effects following exposure to perchlorate. Perchlorate is present in some foods and in dri...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00260.x
更新日期:2010-01-01 00:00:00
abstract::Inflammation is a strong risk factor for cardiovascular disease. Dietary plant sterols are known to reduce plasma cholesterol levels and thereby reduce cardiovascular risk. Recent observations from animal and human studies have demonstrated anti-inflammatory effects of phytosterols. For example, several animal and hum...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2011.00399.x
更新日期:2011-07-01 00:00:00
abstract::In cell cultures of carcinogen-initiated fibroblasts, a number of retinoids and carotenoids can reversibly inhibit progression to the transformed state. The anticarcinogenic action of retinoids and carotenoids is closely correlated with enhanced gap-junction cell-to-cell communication and with increased synthesis of t...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1992.tb01345.x
更新日期:1992-09-01 00:00:00
abstract::The role of polyphenols in human nutrition is discussed on the basis of their redox chemistry, which accounts for the observed antioxidant effect and in turn for their protective effect against atherosclerosis. Epidemiologic data, together with experimental pathology and cell biology, support the recommendation that o...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1999.tb06951.x
更新日期:1999-08-01 00:00:00
abstract::There is much (renewed) interest about the effects of salicylates on food intolerance, attention-deficit disorders, and cardiovascular disease. Current evidence for the efficacy of salicylate-elimination diets in the treatment of attention-deficit disorders and hyperactivity is weak, and further investigation is requi...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1996.tb03940.x
更新日期:1996-08-01 00:00:00
abstract::Some specific hungers for vitamins or minerals can be explained as learned preferences, facilitated by the novel diet preferences shown by rats deficient in specific nutrients. Specific hunger for sodium, however, is a result of an innate, unlearned behavior pattern. ...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1968.tb00820.x
更新日期:1968-01-01 00:00:00
abstract::Lipases are key enzymes in the hydrolysis of triglycerides, phospholipids, and cholesteryl esters, including those of dietary origin. Their actions are essential to maintain lipid homeostasis and cardiovascular health. This report describes the finding and characterization of a new lipase of endothelial origin, one th...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1999.tb01814.x
更新日期:1999-09-01 00:00:00
abstract::Combining data from two large-scale prospective observational studies in women and men, investigators link the consumption of fruits and vegetables to the risk of ischemic stroke. Of interest is their breakdown of these foods into cruciferous vegetables and citrus fruit juice, which confer the greatest protection. ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2001.tb01902.x
更新日期:2001-01-01 00:00:00
abstract::Chronic stress causes the release of glucocorticoids, which greatly influence cerebral function, especially glutamatergic transmission. These stress-induced changes in neurotransmission could be counteracted by increasing the dietary intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs). Numerous studies have desc...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12088
更新日期:2014-02-01 00:00:00
abstract::Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in humans, but they are not generally consumed at levels that effect significant change in biomarkers of health. Because consumers have embraced the notion that dietary supplements may prevent disease, this review considers whether an a...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/nure.12060
更新日期:2013-11-01 00:00:00
abstract::Federal home-delivered meals programs for the frail elderly began in the United States in the 1970s, and during the 1980s the provision of meals to the homebound elderly has been expanded through development of state-funded meals programs. The time has now come to pose two questions relative to coverage and program im...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1994.tb01354.x
更新日期:1994-01-01 00:00:00
abstract::The European Union is implementing a new regulatory framework for nutrition and health claims (HCs) that will greatly impact the communication of health messages on foodstuffs. In particular, approved HCs will be included in a positive register of generic claims. In the currently available literature, assessment of th...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2010.00322.x
更新日期:2010-10-01 00:00:00
abstract::Studies of germ-free and conventional mice revealed that the intestinal bacterial population of the latter contributed to the provision of calories to the host by hydrolysis of indigestible plant polysaccharides to absorbable monosaccharides. The gut microbiota at the same time caused the suppression of a circulating ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2006.tb00173.x
更新日期:2006-01-01 00:00:00
abstract::Iron is essential for oxygen transport, oxidative metabolism, and cellular growth. Interactions between iron and other dietary factors play a significant role in determining the adequacy of iron nutrition and have important implications for food fortification in developing countries. Vitamin A and vitamin C deficiency...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1997.tb06461.x
更新日期:1997-04-01 00:00:00
abstract::The body of knowledge about plants, herbs, and spices and their respective and collective roles in promoting human health is modest. Flavonoids in tea and anthocyanins in tart cherries were presented as examples of how to move forward in understanding active compounds. Dietary compounds, their roles in maintaining hum...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1999.tb01806.x
更新日期:1999-09-01 00:00:00
abstract::Results from human feeding studies and recent large-scale epidemiologic surveys suggest that dietary trans fatty acids enhance the risk of developing coronary heart diseases. Despite a lack of accurate data regarding dietary intake of trans fatty acids, existing epidemiologic data and evidence from experimental feedin...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1998.tb01758.x
更新日期:1998-08-01 00:00:00
abstract::Twenty publications from twelve prospective cohorts have evaluated associations between flavonoid intakes and incidence or mortality from cardiovascular disease (CVD) among adults in Europe and the United States. The most common outcome was coronary heart disease mortality, and four of eight cohort studies reported si...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2012.00508.x
更新日期:2012-09-01 00:00:00
abstract::Dietary fat intake and its effect on human health is a hotly debated issue and major point of interest in nutrition research and practice today. This review traces the history of dietary fat intake, the influence of human evolution on dietary fat intake, and the relationship between dietary fat and health. ...
journal_title:Nutrition reviews
pub_type: 历史文章,杂志文章
doi:10.1111/j.1753-4887.1999.tb01770.x
更新日期:1999-01-01 00:00:00
abstract::Berries contain powerful antioxidants, potential allergens, and other bioactive compounds. Genetic and environmental factors affect production and storage of such compounds. For this reason breeding and biotechnological approaches are currently used to control or to increase the content of specific health-related comp...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00178.x
更新日期:2009-05-01 00:00:00
abstract::The Metabolic Syndrome, also known as Syndrome X, refers to a constellation of atherosclerotic risk factors, including insulin resistance, hyperinsulinemia, dyslipidemia, essential hypertension, and abdominal obesity. We review four major published studies involving animals and humans that may be linked together in a ...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1301/002966402320583398
更新日期:2002-10-01 00:00:00
abstract::Recently, the high responsiveness of omental adipocytes to positive lipolytic stimuli has been clearly demonstrated in women. We conclude that adipose tissue fatty acid release, storage capacity, and secreted cytokines may all be involved in the etiology of the metabolic syndrome. The anatomical location of visceral a...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2007.tb00324.x
更新日期:2007-06-01 00:00:00
abstract::A ventilator-dependent, extremely obese adolescent patient with Prader-Willi syndrome was nutritionally managed using a parenteral, protein-sparing modified fast. A solution containing only amino acids, electrolytes, vitamins, and macro- and micro-minerals helped create a ketotic state and facilitate weaning from the ...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1111/j.1753-4887.1991.tb03035.x
更新日期:1991-08-01 00:00:00
abstract::Prebiotic and probiotic therapies are new strategies being used to treat gastrointestinal diseases. Recent evidence suggests that the administration of select prebiotics and probiotics, alone or in combination (the latter called "synbiotic" therapy) may improve the clinical outcome of patients with ulcerative colitis....
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2006.tb00196.x
更新日期:2006-03-01 00:00:00
abstract:CONTEXT:The association between dairy product intake and the risk of developing type 2 diabetes (T2D) or cardiovascular disease (CVD) has been investigated in several studies, but little attention was given to the role of sex as a moderator of these associations. (In this article, the term "sex" is used to denote the b...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuz006
更新日期:2019-06-01 00:00:00
abstract::Mitochondrial disorders (MDs) are caused by impairment of the mitochondrial electron transport chain (ETC). The ETC is needed for oxidative phosphorylation, which provides the cell with the most efficient energy outcome in terms of ATP production. One of the pathogenic mechanisms of MDs is the accumulation of reactive...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.2009.00221.x
更新日期:2009-08-01 00:00:00
abstract::Evidence mapping is a useful methodology for characterizing existing research on a broad topic and identifying gaps in the scientific literature. Evidence mapping entails conducting a systematic literature search and extracting information on study details, often in the form of a database. Researchers at Tufts Univers...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1093/nutrit/nuz062
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:The omega-3 long-chain polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are important for brain development and cognitive performance. Because they are semi-essential fatty acids, they must be obtained from food. However, the dietary reference intakes of DHA and EPA ha...
journal_title:Nutrition reviews
pub_type: 杂志文章
doi:10.1093/nutrit/nuaa060
更新日期:2020-09-11 00:00:00
abstract::The daily subcutaneous injection of 0.3 U/kg of recombinant growth hormone (GH) for the two years prior to puberty in ten constitutionally growth-retarded children with normal pituitary function resulted in an average height gain of 10 cm per year. No manifestations of GH excess were seen, and a transient alteration i...
journal_title:Nutrition reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1753-4887.1992.tb01326.x
更新日期:1992-07-01 00:00:00