Abstract：
Context:Dairy intake in humans is commonly assessed using questionnaires, but the data collected are often biased. As a result, there is increasing interest in biomarkers of dairy fat. To date, there has been no overview of the fatty acids suitable for use as biomarkers of dairy fat intake. Objective:This systematic review and meta-analysis of observational studies was performed to identify circulating fatty acids as biomarkers of total dairy and dairy fat intakes in the general population. Data Sources:MEDLINE, Embase, and Web of Knowledge databases were searched for eligible studies published until June 2017. Study Selection:Articles were included when a correlation between circulating dairy fatty acids and intakes of total dairy and dairy fat was found, as measured by dietary assessment tools. Data Extraction:Two authors extracted data independently and assessed the risk of bias. An adapted form of the Newcastle-Ottawa Scale was used for quality assessment. Results:Data were pooled using the random-effects model. Meta-analysis revealed that the fatty acids in plasma/serum were significantly correlated with intakes of total dairy (C14:0 [r = 0.15; 95%CI, 0.11 - 0.18], C15:0 [r = 0.20; 95%CI, 0.13 - 0.27], and C17:0 [r = 0.10; 95%CI, 0.03 - 0.16] and dairy fat (C14:0 [r = 0.16; 95%CI, 0.10 - 0.22], C15:0 [r = 0.33; 95%CI, 0.27 - 0.39], C17:0 [r = 0.19; 95%CI, 0.14 - 0.25], and trans-C16:1n-7 [r = 0.21; 95%CI, 0.14 - 0.29). Conclusions:C14:0, C15:0, C17:0, and trans-C16:1n-7 were identified as biomarkers of total dairy and dairy fat intakes in the general population. In light of the suboptimal measurement techniques used in some studies, correlations with trans-C18:1n-7 and conjugated linoleic acid require further investigation.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Pranger IG,Joustra ML,Corpeleijn E,Muskiet FAJ,Kema IP,Oude Elferink SJWH,Singh-Povel C,Bakker SJLdoi
10.1093/nutrit/nuy048subject
Has Abstractpub_date
2019-01-01 00:00:00pages
46-63issue
1eissn
0029-6643issn
1753-4887pii
5126373journal_volume
77pub_type
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